B6NCrl;B6N-Atm1Brd Cul4atm1a(EUCOMM)Hmgu/Ph

Status

Available to order

EMMA IDEM:10587
International strain nameB6NCrl;B6N-Atm1Brd Cul4atm1a(EUCOMM)Hmgu/Ph
Alternative nameHEPD0649_1_F11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCul4atm1a(EUCOMM)Hmgu
Gene/Transgene symbolCul4a
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0649_1_F11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (gene matching)
  • enhanced cued conditioning behavior / IMPC
  • small testis / IMPC
  • decreased spleen weight / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal testis morphology / IMPC
  • abnormal retina morphology / IMPC
  • decreased mean platelet volume / IMPC
  • male infertility / IMPC
  • decreased circulating chloride level / IMPC
  • increased circulating potassium level / IMPC
  • increased fasting circulating glucose level / IMPC
MGI phenotypes (gene matching)
  • small testis / MGI
  • abnormal spermatogenesis / MGI
  • reduced female fertility / MGI
  • male infertility / MGI
  • decreased litter size / MGI
  • asthenozoospermia / MGI
  • oligozoospermia / MGI
  • abnormal cell cycle checkpoint function / MGI
  • decreased testis weight / MGI
  • small epididymis / MGI
  • azoospermia / MGI
  • abnormal male meiosis / MGI
  • reproductive system phenotype / MGI
  • abnormal spermatocyte morphology / MGI
  • abnormal spermatid morphology / MGI
  • abnormal DNA repair / MGI
  • abnormal male germ cell apoptosis / MGI
  • abnormal sperm flagellum morphology / MGI
  • abnormal sperm head morphology / MGI
  • abnormal double-strand DNA break repair / MGI
  • multinucleated giant male germ cells / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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