B6.129P2-Dp(16Lipi-Zbtb21)1TybEmcf/TybH

Status	Available to order
EMMA ID	EM:10557
International strain name	B6.129P2-Dp(16Lipi-Zbtb21)1TybEmcf/TybH
Alternative name	Dp1Tyb
Strain type	Targeted Mutant Strains : Other targeted
Allele/Transgene symbol	Dp(16Lipi-Zbtb21)1TybEmcf
Gene/Transgene symbol	Dp(16Lipi-Zbtb21)1TybEmcf

Information from provider

Provider	Victor Tybulewicz
Provider affiliation	Francis Crick Institute
Additional owner	Elizabeth Fisher, University College London, UK
Genetic information	Duplication of 23Mb of Mmu16 from Lipi to Zbtb21
Phenotypic information	Homozygous: Heterozygous: Mice have congenital heart defects, locomotor dysfunction, electrophysiological changes in hippocampus and learning defects.
Breeding history	Mutant allele was established in HM1 ES cells, then transmitted through the germline and maintained by breeding to C57BL/6J.
References	Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.;Lana-Elola Eva, Watson-Scales Sheona, Slender Amy, Gibbins Dorota, Martineau Alexandrine, Douglas Charlotte, Mohun Timothy, Fisher Elizabeth Mc, Tybulewicz Victor Lj, ;2016;eLife;5;1165-1186; 26765563 Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.;Lana-Elola Eva, Cater Heather, Watson-Scales Sheona, Greenaway Simon, Müller-Winkler Jennifer, Gibbins Dorota, Nemes Mihaela, Slender Amy, Hough Tertius, Keskivali-Bond Piia, Scudamore Cheryl L, Herbert Eleanor, Banks Gareth T, Mobbs Helene, Canonica Tara, Tosh Justin, Noy Suzanna, Llorian Miriam, Nolan Patrick M, Griffin Julian L, Good Mark, Simon Michelle, Mallon Ann-Marie, Wells Sara, Fisher Elizabeth M C, Tybulewicz Victor L J, ;2021;Disease models & mechanisms;14;eadd6883; 34477842 Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;; 28993310 Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.;Lana-Elola Eva, Aoidi Rifdat, Llorian Miriam, Gibbins Dorota, Buechsenschuetz Callan, Bussi Claudio, Flynn Helen, Gilmore Tegan, Watson-Scales Sheona, Haugsten Hansen Marie, Hayward Darryl, Song Ok-Ryul, Brault Véronique, Herault Yann, Deau Emmanuel, Meijer Laurent, Snijders Ambrosius P, Gutierrez Maximiliano G, Fisher Elizabeth M C, Tybulewicz Victor L J, ;2024;Science translational medicine;16;; 38266108
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous C57BL/6J
Breeding at archiving centre	Backcrossed 6 times to C57BL/6J

Disease and phenotype information

MGI allele-associated human disease models

Down syndrome / DOID:14250

Literature references

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.;Lana-Elola Eva, Watson-Scales Sheona, Slender Amy, Gibbins Dorota, Martineau Alexandrine, Douglas Charlotte, Mohun Timothy, Fisher Elizabeth Mc, Tybulewicz Victor Lj, ;2016;eLife;5;1165-1186; 26765563
Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.;Lana-Elola Eva, Cater Heather, Watson-Scales Sheona, Greenaway Simon, Müller-Winkler Jennifer, Gibbins Dorota, Nemes Mihaela, Slender Amy, Hough Tertius, Keskivali-Bond Piia, Scudamore Cheryl L, Herbert Eleanor, Banks Gareth T, Mobbs Helene, Canonica Tara, Tosh Justin, Noy Suzanna, Llorian Miriam, Nolan Patrick M, Griffin Julian L, Good Mark, Simon Michelle, Mallon Ann-Marie, Wells Sara, Fisher Elizabeth M C, Tybulewicz Victor L J, ;2021;Disease models & mechanisms;14;eadd6883; 34477842
Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;; 28993310
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.;Lana-Elola Eva, Aoidi Rifdat, Llorian Miriam, Gibbins Dorota, Buechsenschuetz Callan, Bussi Claudio, Flynn Helen, Gilmore Tegan, Watson-Scales Sheona, Haugsten Hansen Marie, Hayward Darryl, Song Ok-Ryul, Brault Véronique, Herault Yann, Deau Emmanuel, Meijer Laurent, Snijders Ambrosius P, Gutierrez Maximiliano G, Fisher Elizabeth M C, Tybulewicz Victor L J, ;2024;Science translational medicine;16;; 38266108

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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