B6(Cg)-Ins1tm1.1(cre)Thor/H

Status

Available to order

EMMA IDEM:10468
Citation informationRRID:IMSR_EM:10468 

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International strain nameB6(Cg)-Ins1tm1.1(cre)Thor/H
Alternative nameINS1Cre
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIns1tm1.1(cre)Thor
Gene/Transgene symbolIns1

Information from provider

ProviderJorge Ferrer
Provider affiliationDepartment of Medicine, Faculty of Medicine
Genetic informationA cre-neo cassette was inserted at the initiation codon (exon 2) of Ins1 to produce Ins1tm1(cre)Thor. The FRT flanked neo was removed via flp recombinase to produce Ins1tm1.1(cre)Thor.
Phenotypic informationHomozygous:
No overt phenotype seen. Mice carrying the Ins1 allele were shown to drive efficient and selective recombination of floxed genes in pancreatic beta cells from birth with no recombination in the central nervous system.

Heterozygous:
No overt phenotype seen. Mice carrying the Ins1 allele were shown to drive efficient and selective recombination of floxed genes in pancreatic beta cells from birth with no recombination in the central nervous system.
References
  • Ins1(Cre) knock-in mice for beta cell-specific gene recombination.;Thorens Bernard, Tarussio David, Maestro Miguel Angel, Rovira Meritxell, Heikkilä Eija, Ferrer Jorge, ;2015;Diabetologia;58;558-65; 25500700
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased exploration in new environment / IMPC
  • decreased grip strength / IMPC
  • thin ventricular wall / IMPC
MGI phenotypes (allele matching)
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
MGI phenotypes (gene matching)
  • no phenotypic analysis / MGI
  • increased pancreatic beta cell number / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • increased pancreatic beta cell mass / MGI

Literature references

  • Ins1(Cre) knock-in mice for beta cell-specific gene recombination.;Thorens Bernard, Tarussio David, Maestro Miguel Angel, Rovira Meritxell, Heikkilä Eija, Ferrer Jorge, ;2015;Diabetologia;58;558-65; 25500700

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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Practical information

Genotyping protocol

Example health report
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