C57BL/6N-Arid1b^{tm1a(EUCOMM)Hmgu}/Cnbc

Status	Available to order
EMMA ID	EM:10411
Citation information	RRID:IMSR_EM:10411 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Arid1b^{tm1a(EUCOMM)Hmgu}/Cnbc
Alternative name	C57BL/6N-Arid1b/Cnbc
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Arid1b^{tm1a(EUCOMM)Hmgu}
Gene/Transgene symbol	Arid1b

Information from provider

Provider	Pedro Medina
Provider affiliation	Pfizer - Junta de Andalucia - Universidad de Granada, Center for Genomics and Ontology Reseach (GenyO)
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0532_6_A11.
Phenotypic information	Homozygous: Potential phenotyping data in the IMPC portal Heterozygous: See above
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Coffin-Siris syndrome / Orphanet_1465

IMPC phenotypes (gene matching)

abnormal spleen morphology / IMPC
decreased prepulse inhibition / IMPC
preweaning lethality, complete penetrance / IMPC
decreased locomotor activity / IMPC
impaired cued conditioning behavior / IMPC
edema / IMPC
male infertility / IMPC
increased circulating creatinine level / IMPC
increased freezing behavior / IMPC
abnormal freezing behavior / IMPC
decreased exploration in new environment / IMPC
decreased fasting circulating glucose level / IMPC
preweaning lethality, incomplete penetrance / IMPC

MGI phenotypes (gene matching)

muscle weakness / MGI
decreased corpus callosum size / MGI
abnormal dentate gyrus morphology / MGI
decreased body length / MGI
decreased body weight / MGI
decreased body size / MGI
increased anxiety-related response / MGI
increased grooming behavior / MGI
abnormal vocalization / MGI
postnatal growth retardation / MGI
abnormal homeostasis / MGI
hydroencephaly / MGI
small heart / MGI
decreased heart weight / MGI
small kidney / MGI
decreased kidney weight / MGI
decreased circulating insulin-like growth factor I level / MGI
behavior/neurological phenotype / MGI
abnormal hypothalamus physiology / MGI
thin cerebral cortex / MGI
abnormal insulin-like growth factor I level / MGI
decreased neuron number / MGI
decreased birth body size / MGI
decreased grip strength / MGI
perinatal lethality, complete penetrance / MGI
decreased dentate gyrus size / MGI
abnormal response to social novelty / MGI
decreased cerebral cortex cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

INFRAFRONTIER^® and European Mouse Mutant Archive - EMMA^® are registered trademarks at the European Union Intellectual Property Office (EUIPO).

C57BL/6N-Arid1btm1a(EUCOMM)Hmgu/Cnbc