STOCK Aviltm1(HBEGF)Phep/Cnrm

Status

Available to order

EMMA IDEM:10409
Citation informationRRID:IMSR_EM:10409 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Aviltm1(HBEGF)Phep/Cnrm
Alternative nameAvil-iDTR
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolAviltm1(HBEGF)Phep
Gene/Transgene symbolAvil

Information from provider

ProviderPaul Heppenstall
Provider affiliation Adriano Buzzati-Traverso Campus, EMBL Monterotondo
Genetic informationiDTR cassette has been inserted into the advillin locus replacing exon 2 and 66bp upstream thereof, creating a permanent null situation.
Phenotypic informationWhen crossed with an appropriate Cre line allows Diphtheria toxin-mediated ablation of sensory neurons.
References
  • A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.;Stantcheva Kalina K, Iovino Loredana, Dhandapani Rahul, Martinez Concepcion, Castaldi Laura, Nocchi Linda, Perlas Emerald, Portulano Carla, Pesaresi Martina, Shirlekar Kalyanee S, de Castro Reis Fernanda, Paparountas Triantafillos, Bilbao Daniel, Heppenstall Paul A, ;2016;EMBO reports;17;585-600; 26929027
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal dorsal root ganglion morphology / MGI
  • abnormal mechanical nociception / MGI
  • allodynia / MGI
  • abnormal axon extension / MGI
  • decreased thermal nociceptive threshold / MGI
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • abnormal neurite morphology / MGI
  • decreased survivor rate / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • impaired central nervous system regeneration / MGI

Literature references

  • A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.;Stantcheva Kalina K, Iovino Loredana, Dhandapani Rahul, Martinez Concepcion, Castaldi Laura, Nocchi Linda, Perlas Emerald, Portulano Carla, Pesaresi Martina, Shirlekar Kalyanee S, de Castro Reis Fernanda, Paparountas Triantafillos, Bilbao Daniel, Heppenstall Paul A, ;2016;EMBO reports;17;585-600; 26929027

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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