- abnormal dorsal root ganglion morphology / MGI
- abnormal mechanical nociception / MGI
- allodynia / MGI
- abnormal axon extension / MGI
- decreased thermal nociceptive threshold / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal neurite morphology / MGI
- decreased survivor rate / MGI
- prenatal lethality, incomplete penetrance / MGI
- impaired central nervous system regeneration / MGI
STOCK Aviltm1(HBEGF)Phep/Cnrm
Status | Available to order |
EMMA ID | EM:10409 |
International strain name | STOCK Aviltm1(HBEGF)Phep/Cnrm |
Alternative name | Avil-iDTR |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Aviltm1(HBEGF)Phep |
Gene/Transgene symbol | Avil |
Information from provider
Provider | Paul Heppenstall |
Provider affiliation | Adriano Buzzati-Traverso Campus, EMBL Monterotondo |
Genetic information | iDTR cassette has been inserted into the advillin locus replacing exon 2 and 66bp upstream thereof, creating a permanent null situation. |
Phenotypic information | When crossed with an appropriate Cre line allows Diphtheria toxin-mediated ablation of sensory neurons. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.;Stantcheva Kalina K, Iovino Loredana, Dhandapani Rahul, Martinez Concepcion, Castaldi Laura, Nocchi Linda, Perlas Emerald, Portulano Carla, Pesaresi Martina, Shirlekar Kalyanee S, de Castro Reis Fernanda, Paparountas Triantafillos, Bilbao Daniel, Heppenstall Paul A, ;2016;EMBO reports;17;585-600; 26929027
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