IMPC phenotypes (gene matching)
- abnormal response to new environment / IMPC
STOCK Smyd3Gt(AS0527)Wtsi/Flmg
| Status | Available to order |
| EMMA ID | EM:10367 |
| Citation information | RRID:IMSR_EM:10367 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Smyd3Gt(AS0527)Wtsi/Flmg |
| Alternative name | B6.CB-Smyd3 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Smyd3Gt(AS0527)Wtsi |
| Gene/Transgene symbol | Smyd3 |
Information from provider
| Provider | Iannis Talianidis |
| Provider affiliation | BSRC Alexander Fleming |
| Genetic information | Standard Smyd3-deficient (Smyd3-KO) mice were generated using gene-trap ES cell clones (AS0527 from International Gene Trap Consortium), in which a selection cassette, containing the splice acceptor site from mouse En2 exon 2 followed by the beta geo gene and the SV40 polyadenylation sequence was inserted into the 5th intron of the Smyd3 gene. The resulting mice were devoid of Smyd3 mRNA and protein in all tissues, including liver and colon. |
| Phenotypic information | Homozygous:Mice are phenotypically normal and viable. Livers are visibly and microscopically normal.Heterozygous:same as homozygous |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous CBA x C57BL/6 males, wild-type (C57BL/6 x CBA)F1 females |
| Stage of embryos | Morula |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
Literature references
- Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.;Sarris Michalis E, Moulos Panagiotis, Haroniti Anna, Giakountis Antonis, Talianidis Iannis, ;2016;Cancer cell;29;354-366; 26908355