C57BL/6J-Tg(Pax8-cre/ERT2)CAmat/AmatH
| Status | Available to order |
| EMMA ID | EM:10364 |
| Citation information | RRID:IMSR_EM:10364 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Tg(Pax8-cre/ERT2)CAmat/AmatH |
| Alternative name | Pax8-CreERT2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Pax8-cre/ERT2)CAmat |
| Gene/Transgene symbol | Tg(Pax8-cre/ERT2)CAmat |
Information from provider
| Provider | Athena Matakidou |
| Provider affiliation | University of Cambridge CRUK Cambridge Institute |
| Genetic information | Transgenic mouse expressing a CreERT2 cassette from the mouse Pax8 promoter (4.3kb of upstream regulatory sequence, complete exon 1 and intron 1, part of exon 2 and 0.8kb of intron 2 of the murine Pax8 gene). Upon tamoxifen administration Cre recombinase is exclusively expressed in renal tubular epithelia (proximal and distal tubules as well as collecting ducts). |
| Phenotypic information | Heterozygous and homozygous Pax8-CreERT2 mice are viable and display no discernible phenotype. Upon tamoxifen administration Cre recombinase is exclusively expressed in renal tubular epithelia (proximal and distal tubules as well as collecting ducts). |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.;Espana-Agusti Judit, Zou Xiangang, Wong Kim, Fu Beiyuan, Yang Fengtang, Tuveson David A, Adams David J, Matakidou Athena, ;2016;PloS one;11;e0148055; 26866916