MGI phenotypes (gene matching)
B6;129S4-Slc22a6tm1.1(cre/ERT2)Amat/H
| Status | Available to order |
| EMMA ID | EM:10363 |
| International strain name | B6;129S4-Slc22a6tm1.1(cre/ERT2)Amat/H |
| Alternative name | Slc22a6-CreERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Slc22a6tm1.1(cre/ERT2)Amat |
| Gene/Transgene symbol | Slc22a6 |
Information from provider
| Provider | Athena Matakidou |
| Provider affiliation | University of Cambridge CRUK Cambridge Institute |
| Genetic information | The CreERT2 gene was inserted at the endogenous ATG start site of the mouse Slc22a6 gene. This strain expresses the CreERT2 recombinase (tamoxifen-inducible) in Slc22a6 positive epithelia of proximal renal tubules. |
| Phenotypic information | Heterozygous and homozygous Slc22a6-CreERT2 mice are viable and display no discernible phenotype. Upon administration of tamoxifen recombinase activity is induced specifically in the epithelia of proximal renal tubules. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.;Espana-Agusti Judit, Zou Xiangang, Wong Kim, Fu Beiyuan, Yang Fengtang, Tuveson David A, Adams David J, Matakidou Athena, ;2016;PloS one;11;e0148055; 26866916