MGI phenotypes (gene matching)
B6;129S4-Slc22a6tm1.1(cre/ERT2)Amat/H
| Status | Available to order |
| EMMA ID | EM:10363 |
| Citation information | RRID:IMSR_EM:10363 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S4-Slc22a6tm1.1(cre/ERT2)Amat/H |
| Alternative name | Slc22a6-CreERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Slc22a6tm1.1(cre/ERT2)Amat |
| Gene/Transgene symbol | Slc22a6 |
Information from provider
| Provider | Athena Matakidou |
| Provider affiliation | University of Cambridge CRUK Cambridge Institute |
| Genetic information | The CreERT2 gene was inserted at the endogenous ATG start site of the mouse Slc22a6 gene. This strain expresses the CreERT2 recombinase (tamoxifen-inducible) in Slc22a6 positive epithelia of proximal renal tubules. |
| Phenotypic information | Heterozygous and homozygous Slc22a6-CreERT2 mice are viable and display no discernible phenotype. Upon administration of tamoxifen recombinase activity is induced specifically in the epithelia of proximal renal tubules. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.;Espana-Agusti Judit, Zou Xiangang, Wong Kim, Fu Beiyuan, Yang Fengtang, Tuveson David A, Adams David J, Matakidou Athena, ;2016;PloS one;11;e0148055; 26866916