C57BL/6NTac-Dusp3tm1a(KOMP)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:10346
Citation informationRRID:IMSR_EM:10346 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Dusp3tm1a(KOMP)Wtsi/WtsiBiat
Alternative nameEPD0090_4_C10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolDusp3tm1a(KOMP)Wtsi
Gene/Transgene symbolDusp3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0090_4_C10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased leukocyte cell number / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased lean body mass / IMPC
  • abnormal humerus morphology / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased circulating creatinine level / IMPC
  • increased mean corpuscular hemoglobin / IMPC
IMPC phenotypes (gene matching)
  • decreased grip strength / IMPC
  • increased circulating glycerol level / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased lean body mass / IMPC
  • decreased circulating creatinine level / IMPC
  • increased leukocyte cell number / IMPC
  • abnormal humerus morphology / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased red blood cell distribution width / IMPC
  • decreased bone mineral content / IMPC
  • increased circulating insulin level / IMPC
MGI phenotypes (allele matching)
  • decreased circulating creatinine level / MGI
MGI phenotypes (gene matching)
  • decreased hemoglobin content / MGI
  • decreased circulating creatinine level / MGI
  • decreased angiogenesis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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