C3HeB/FeJ-Hoxb1m1Mhda/Ieg

Status

Available to order

EMMA IDEM:10203
Citation informationRRID:IMSR_EM:10203 

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International strain nameC3HeB/FeJ-Hoxb1m1Mhda/Ieg
Alternative nameC3HeB/FeJ-Hoxb1T207AMhda
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolHoxb1m1Mhda
Gene/Transgene symbolHoxb1

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum München
Genetic informationExon 2 c.619 A to G, p.Thr207Ala; PROVEAN prediction: -4.105 (deleterious).
Phenotypic informationHomozygous:
Not phenotyped.

Heterozygous:
Not phenotyped.
Breeding historyOutcrossed candidate gene obtained by next generation sequencing of ENU mutagenesis-derived mutant lines.
ReferencesNone available
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivinghomozygous C3H males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Congenital hereditary facial paralysis-variable hearing loss syndrome / Orphanet_306530
MGI phenotypes (gene matching)
  • abnormal craniofacial morphology / MGI
  • absent facial nuclei / MGI
  • abnormal facial motor nucleus morphology / MGI
  • small facial motor nucleus / MGI
  • decreased sensory neuron number / MGI
  • abnormal facial nerve morphology / MGI
  • decreased body size / MGI
  • abnormal reflex / MGI
  • abnormal tooth morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal axon guidance / MGI
  • no phenotypic analysis / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system morphology / MGI
  • abnormal masseter muscle morphology / MGI
  • abnormal temporalis muscle morphology / MGI
  • absent facial nerve / MGI
  • behavior/neurological phenotype / MGI
  • abnormal neuron differentiation / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • abnormal cochlear VIII nucleus morphology / MGI
  • abnormal lower lip morphology / MGI
  • abnormal rhombomere 4 morphology / MGI
  • absent facial muscle / MGI
  • narrow face / MGI
  • facial paralysis / MGI
  • facial muscle degeneration / MGI
  • abnormal digastric posterior belly morphology / MGI
  • abnormal buccinator muscle morphology / MGI
  • abnormal depressor anguli oris muscle morphology / MGI
  • abnormal zygomaticus muscle morphology / MGI
  • absent levator nasolabialis muscle / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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