C57BL/6N-Atm1Brd Smg9tm1a(EUCOMM)Wtsi/WtsiCnrm

Status

Available to order

EMMA IDEM:10195
International strain nameC57BL/6N-Atm1Brd Smg9tm1a(EUCOMM)Wtsi/WtsiCnrm
Alternative nameEPD0428_2_D07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSmg9tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSmg9
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0428_2_D07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal embryo size / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • exencephaly / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal behavior / IMPC
  • decreased thigmotaxis / IMPC
  • hyperactivity / IMPC
  • decreased circulating glucose level / IMPC
MGI phenotypes (gene matching)
  • lordosis / MGI
  • abnormal interatrial septum morphology / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • absent kidney / MGI
  • polydactyly / MGI
  • enlarged liver sinusoidal spaces / MGI
  • abnormal pineal gland morphology / MGI
  • exencephaly / MGI
  • absent superior cervical ganglion / MGI
  • small superior cervical ganglion / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal lens morphology / MGI
  • edema / MGI
  • hemorrhage / MGI
  • abnormal nasal cavity morphology / MGI
  • thin myocardium / MGI
  • abnormal vein morphology / MGI
  • aphakia / MGI
  • liver cysts / MGI
  • aorta coarctation / MGI
  • abnormal eye muscle morphology / MGI
  • atrium hypoplasia / MGI
  • abnormal neurohypophysis morphology / MGI
  • decreased fetal size / MGI
  • fetal growth retardation / MGI
  • abnormal optic cup morphology / MGI
  • basisphenoid bone foramen / MGI
  • fusion of vertebral bodies / MGI
  • abnormal middle ear ossicle morphology / MGI
  • coloboma / MGI
  • abnormal endolymphatic duct morphology / MGI
  • abnormal inferior vena cava morphology / MGI
  • abnormal heart position or orientation / MGI
  • abnormal cervical rib / MGI
  • thoracoschisis / MGI
  • preaxial polydactyly / MGI
  • abnormal optic chiasm morphology / MGI
  • absent optic chiasm / MGI
  • atrioventricular septal defect / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • persistent right dorsal aorta / MGI
  • left atrium hypoplasia / MGI
  • postnatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • double ureter / MGI
  • interrupted aortic arch, type b / MGI
  • decreased midbrain size / MGI
  • decreased hindbrain size / MGI
  • abnormal hypoglossal nerve topology / MGI
  • absent segment of posterior cerebral artery / MGI
  • subcutaneous edema / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve morphology / MGI
  • duplication of ductus venosus / MGI
  • persistent right 6th pharyngeal arch artery / MGI
  • reduced sympathetic cervical ganglion size / MGI
  • absent connection between subcutaneous lymph vessels and lymph sac / MGI
  • blood in lymph vessels / MGI
  • heterochrony / MGI
  • abnormal lens topology / MGI
  • persistent trigeminal artery / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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