IMPC phenotypes (gene matching)
B6.129S4-Rasgrf1tm2Pds/Cnrm
| Status | Available to order |
| EMMA ID | EM:10177 |
| Citation information | RRID:IMSR_EM:10177 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S4-Rasgrf1tm2Pds/Cnrm |
| Alternative name | Rasgrf1tm2Pds |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Rasgrf1tm2Pds |
| Gene/Transgene symbol | Rasgrf1 |
Information from provider
| Provider | Riccardo Brambilla |
| Provider affiliation | School of Biosciences, Cardiff University |
| Genetic information | Ras-GRF1 mutant mouse. |
| Phenotypic information | Homozygous:None, the mutation is only evident in one allele.Heterozygous:Imprinted methylation of the paternal Rasgrf1 allele is removed, allowing biallelic expression. In addition, this mutant shows overexpression of the Ras-GRF1 protein and alterations both in memory consolidation and behavioural responses to drugs of abuse. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- postnatal growth retardation / MGI
- abnormal pituitary secretion / MGI
- impaired synaptic plasticity / MGI
- no abnormal phenotype detected / MGI
- decreased circulating insulin level / MGI
- abnormal active avoidance behavior / MGI
- abnormal discrimination learning / MGI
- abnormal excitatory postsynaptic potential / MGI
- impaired social transmission of food preference / MGI
- no phenotypic analysis / MGI
- maternal imprinting / MGI
- paternal imprinting / MGI
- decreased pancreatic beta cell number / MGI
- nervous system phenotype / MGI
- abnormal imprinting / MGI
- decreased circulating insulin-like growth factor I level / MGI
- decreased growth hormone level / MGI
- impaired glucose tolerance / MGI
- behavior/neurological phenotype / MGI
- enhanced lipolysis / MGI
- abnormal long term spatial reference memory / MGI
- abnormal DNA methylation / MGI
- small pancreatic islets / MGI
- impaired contextual conditioning behavior / MGI
- decreased total body fat amount / MGI
Literature references
- Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker.;Yoon Bongjune, Herman Herry, Hu Benjamin, Park Yoon Jung, Lindroth Anders, Bell Adam, West Adam G, Chang Yanjie, Stablewski Aimee, Piel Jessica C, Loukinov Dmitri I, Lobanenkov Victor V, Soloway Paul D, ;2005;Molecular and cellular biology;25;11184-90; 16314537
- Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.;Fasano Stefania, D'Antoni Angela, Orban Paul C, Valjent Emmanuel, Putignano Elena, Vara Hugo, Pizzorusso Tommaso, Giustetto Maurizio, Yoon Bongjune, Soloway Paul, Maldonado Rafael, Caboche Jocelyne, Brambilla Riccardo, ;2009;Biological psychiatry;66;758-68; 19446794