IMPC phenotypes (gene matching)
C57BL/6N-Ntrk1tm1c(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:10147 |
| Citation information | RRID:IMSR_EM:10147 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Ntrk1tm1c(EUCOMM)Wtsi/H |
| Alternative name | EPD0688_6_D04 |
| Strain type | Targeted Mutant Strains : Targeted Conditional |
| Allele/Transgene symbol | Ntrk1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Ntrk1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from EUCOMM ES clone EPD0688_6_D04, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary sensory and autonomic neuropathy type 4 / Orphanet_642
- Familial medullary thyroid carcinoma / Orphanet_99361
MGI phenotypes (gene matching)
- mottled coat / MGI
- ulcerated paws / MGI
- small dorsal root ganglion / MGI
- decreased sensory neuron number / MGI
- abnormal sensory neuron innervation pattern / MGI
- abnormal sympathetic ganglion morphology / MGI
- small superior cervical ganglion / MGI
- abnormal cholinergic neuron morphology / MGI
- small trigeminal ganglion / MGI
- skin lesions / MGI
- decreased body size / MGI
- corneal opacity / MGI
- blepharoptosis / MGI
- abnormal vibrissae reflex / MGI
- unresponsive to tactile stimuli / MGI
- abnormal pain threshold / MGI
- increased thermal nociceptive threshold / MGI
- miotic pupils / MGI
- premature death / MGI
- abnormal digit morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal chemical nociception / MGI
- abnormal nociception after inflammation / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- abnormal thermosensation / MGI
- decreased thermal nociceptive threshold / MGI
- abnormal sympathetic nervous system physiology / MGI
- abnormal proprioceptive neuron morphology / MGI
- abnormal neuron physiology / MGI
- hearing/vestibular/ear phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal neurite morphology / MGI
- increased muscle spindle number / MGI
- abnormal sensory neuron physiology / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI