- increased basophil cell number / IMPC
- abnormal sinus arrhythmia / IMPC
- abnormal pelvic girdle bone morphology / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- abnormal snout morphology / IMPC
- abnormal tooth morphology / IMPC
- abnormal maxilla morphology / IMPC
- abnormal iris morphology / IMPC
- narrow eye opening / IMPC
- abnormal scapula morphology / IMPC
C57BL/6N-Sirt1tm1c(EUCOMM)Wtsi/H
Status | Available to order |
EMMA ID | EM:10146 |
International strain name | C57BL/6N-Sirt1tm1c(EUCOMM)Wtsi/H |
Alternative name | EPD0428_2_B04 |
Strain type | Targeted Mutant Strains : Targeted Conditional |
Allele/Transgene symbol | Sirt1tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Sirt1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This line originates from EUCOMM ES clone EPD0428_2_B04, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal heart development / MGI
- enlarged heart / MGI
- heart right ventricle hypertrophy / MGI
- abnormal cell death / MGI
- abnormal craniofacial morphology / MGI
- abnormal head morphology / MGI
- short snout / MGI
- abnormal salivary gland morphology / MGI
- abnormal mammary gland morphology / MGI
- abnormal branching of the mammary ductal tree / MGI
- enlarged spleen / MGI
- exencephaly / MGI
- abnormal retinal photoreceptor morphology / MGI
- small ovary / MGI
- absent corpus luteum / MGI
- small seminiferous tubules / MGI
- arrest of spermatogenesis / MGI
- abnormal spermatogenesis / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal eye development / MGI
- microphthalmia / MGI
- abnormal eyelid morphology / MGI
- abnormal lacrimal gland morphology / MGI
- abnormal nursing / MGI
- hypoactivity / MGI
- polydipsia / MGI
- polyphagia / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- decreased white adipose tissue amount / MGI
- lung inflammation / MGI
- interstitial pneumonia / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- male infertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- abnormal glucose homeostasis / MGI
- perinatal lethality / MGI
- postnatal lethality / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- no abnormal phenotype detected / MGI
- decreased brain weight / MGI
- abnormal seminiferous tubule morphology / MGI
- increased immunoglobulin level / MGI
- asthenozoospermia / MGI
- globozoospermia / MGI
- oligozoospermia / MGI
- decreased circulating insulin level / MGI
- glomerulonephritis / MGI
- abnormal atrioventricular valve morphology / MGI
- decreased circulating luteinizing hormone level / MGI
- abnormal testes secretion / MGI
- decreased circulating follicle stimulating hormone level / MGI
- decreased urine osmolality / MGI
- no phenotypic analysis / MGI
- increased insulin secretion / MGI
- enlarged pancreas / MGI
- abnormal chromosome morphology / MGI
- increased autoantibody level / MGI
- abnormal retinal layer morphology / MGI
- pulmonary edema / MGI
- aneuploidy / MGI
- abnormal cell cycle checkpoint function / MGI
- abnormal Sertoli cell development / MGI
- increased cellular sensitivity to ionizing radiation / MGI
- increased mitotic index / MGI
- increased anti-nuclear antigen antibody level / MGI
- decreased testis weight / MGI
- abnormal uterus size / MGI
- eyelids fail to open / MGI
- lethargy / MGI
- increased brain size / MGI
- increased oxygen consumption / MGI
- abnormal glucose tolerance / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal inguinal fat pad morphology / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- abnormal energy expenditure / MGI
- decreased circulating thyroxine level / MGI
- Leydig cell hypoplasia / MGI
- teratozoospermia / MGI
- ocular hypotelorism / MGI
- abnormal mammary gland growth during pregnancy / MGI
- abnormal digit development / MGI
- abnormal spermatocyte morphology / MGI
- abnormal spermatid morphology / MGI
- abnormal DNA replication / MGI
- abnormal DNA repair / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- arrest of male meiosis / MGI
- abnormal male germ cell apoptosis / MGI
- increased cellular sensitivity to ultraviolet irradiation / MGI
- slow postnatal weight gain / MGI
- disorganized retinal inner nuclear layer / MGI
- disorganized retinal outer nuclear layer / MGI
- decreased survivor rate / MGI
- anovulation / MGI
- abnormal sperm flagellum morphology / MGI
- absent estrous cycle / MGI
- exocrine pancreas atrophy / MGI
- abnormal palatal rugae morphology / MGI
- decreased respiratory quotient / MGI
- ventricular septal defect / MGI
- atrial septal defect / MGI
- mortality/aging / MGI
- hyperpnea / MGI
- abnormal cellular respiration / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- increased urine antidiuretic hormone level / MGI
- abnormal seminiferous tubule epithelium morphology / MGI
- increased food intake / MGI
- hypoactivity in response to feed restriction / MGI
- absent hindlimb buds / MGI
- abnormal adult Leydig cell differentiation / MGI
- hypolactation / MGI
- renal glomerular immunoglobulin deposits / MGI
- multinucleated giant male germ cells / MGI
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