C57BL/6N-Fgf10tm1c(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:10144
International strain nameC57BL/6N-Fgf10tm1c(EUCOMM)Wtsi/H
Alternative nameEPD0378_4_A02
Strain typeTargeted Mutant Strains : Targeted Conditional
Allele/Transgene symbolFgf10tm1c(EUCOMM)Wtsi
Gene/Transgene symbolFgf10
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis line originates from EUCOMM ES clone EPD0378_4_A02, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • increased total body fat amount / IMPC
  • narrow eye opening / IMPC
  • increased circulating cholesterol level / IMPC
  • abnormal cornea morphology / IMPC
  • impaired pupillary reflex / IMPC
  • decreased grip strength / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • decreased lean body mass / IMPC
  • decreased leukocyte cell number / IMPC
  • corneal opacity / IMPC
  • abnormal behavior / IMPC
  • decreased locomotor activity / IMPC
  • decreased thigmotaxis / IMPC
MGI phenotypes (gene matching)
  • abnormal adipose tissue morphology / MGI
  • small ears / MGI
  • abnormal inner ear morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal inner ear vestibule morphology / MGI
  • abnormal scapula morphology / MGI
  • abnormal hair follicle morphology / MGI
  • decreased hair follicle number / MGI
  • abnormal pulmonary trunk morphology / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal colon morphology / MGI
  • abnormal urethra morphology / MGI
  • absent limbs / MGI
  • absent forelimb / MGI
  • absent radius / MGI
  • absent hindlimb / MGI
  • absent salivary gland / MGI
  • dextrocardia / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • small thymus / MGI
  • abnormal tongue morphology / MGI
  • abnormal sensory neuron innervation pattern / MGI
  • abnormal male reproductive system morphology / MGI
  • abnormal prostate gland morphology / MGI
  • absent prostate gland / MGI
  • abnormal lung development / MGI
  • absent lungs / MGI
  • thin skin / MGI
  • translucent skin / MGI
  • abnormal epidermal layer morphology / MGI
  • thin epidermis / MGI
  • decreased body weight / MGI
  • microphthalmia / MGI
  • eyelids open at birth / MGI
  • abnormal lens morphology / MGI
  • abnormal embryo development / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal tooth morphology / MGI
  • abnormal ear morphology / MGI
  • abnormal respiratory system morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal pulmonary circulation / MGI
  • abnormal forced expiratory flow rates / MGI
  • small stomach / MGI
  • abnormal inner ear canal morphology / MGI
  • absent bulbourethral gland / MGI
  • abnormal lens fiber morphology / MGI
  • small kidney / MGI
  • abnormal kidney medulla morphology / MGI
  • hypospadia / MGI
  • decreased lateral semicircular canal size / MGI
  • absent posterior semicircular canal / MGI
  • absent superior semicircular canal / MGI
  • abnormal pulmonary elastic fiber morphology / MGI
  • abnormal lens epithelium morphology / MGI
  • pancreas fibrosis / MGI
  • decreased pancreatic beta cell number / MGI
  • abnormal hypaxial muscle morphology / MGI
  • epididymal cyst / MGI
  • small lung / MGI
  • absent seminal vesicle / MGI
  • abnormal palate morphology / MGI
  • decreased palatal length / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal Wolffian duct morphology / MGI
  • diaphragmatic hernia / MGI
  • abnormal gastric chief cell morphology / MGI
  • decreased fetal size / MGI
  • small pancreas / MGI
  • abnormal crista ampullaris morphology / MGI
  • small vestibular saccule / MGI
  • absent humerus / MGI
  • absent ulna / MGI
  • abnormal pelvic girdle bone morphology / MGI
  • abnormal vestibular hair cell stereociliary bundle morphology / MGI
  • absent limb buds / MGI
  • short incisors / MGI
  • abnormal large intestine crypts of Lieberkuhn morphology / MGI
  • narrow eye opening / MGI
  • absent thyroid gland / MGI
  • absent pituitary gland / MGI
  • abnormal incisor morphology / MGI
  • muscle phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • abnormal limb bud morphology / MGI
  • impaired lung alveolus development / MGI
  • abnormal heart position or orientation / MGI
  • abnormal retinal apoptosis / MGI
  • abnormal utricle morphology / MGI
  • abnormal limb development / MGI
  • small otic capsule / MGI
  • small molars / MGI
  • absent adenohypophysis / MGI
  • abnormal hindgut morphology / MGI
  • abnormal mammary fat pad morphology / MGI
  • abnormal cecum development / MGI
  • absent rectum / MGI
  • cecal atresia / MGI
  • submandibular gland hypoplasia / MGI
  • absent submandibular gland / MGI
  • abnormal submandibular duct morphology / MGI
  • abnormal secondary palate development / MGI
  • palatal shelf fusion with tongue or mandible / MGI
  • cleft secondary palate / MGI
  • abnormal primitive urogenital sinus morphology / MGI
  • abnormal heart atrium auricular region morphology / MGI
  • absent pulmonary artery / MGI
  • absent pulmonary vein / MGI
  • abnormal hair follicle bulb morphology / MGI
  • abnormal stomach submucosa morphology / MGI
  • absent lung buds / MGI
  • abnormal branching involved in trachea morphogenesis / MGI
  • impaired branching involved in bronchus morphogenesis / MGI
  • impaired branching involved in preterminal bronchiole morphogenesis / MGI
  • abnormal vestibular hair cell kinocilium morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • increased hair follicle apoptosis / MGI
  • dilated kidney calyx / MGI
  • abnormal kidney outer medulla morphology / MGI
  • abnormal kidney inner medulla morphology / MGI
  • abnormal metanephric ureteric bud development / MGI
  • absent Rathke's pouch / MGI
  • absent colon / MGI
  • tongue ankylosis / MGI
  • abnormal neurohypophysis development / MGI
  • abnormal Rathke's pouch apoptosis / MGI
  • Harderian gland atrophy / MGI
  • decreased trachea gland number / MGI
  • abnormal periderm development / MGI
  • abnormal nasal gland morphology / MGI
  • abnormal lateral nasal gland morphology / MGI
  • abnormal mammary placode morphology / MGI
  • absent palatal rugae / MGI
  • decreased colon length / MGI

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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