C57BL/6NTac-Nr5a1tm1(EGFP/cre/ERT2)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:10083
International strain nameC57BL/6NTac-Nr5a1tm1(EGFP/cre/ERT2)Wtsi/WtsiIeg
Alternative nameCEPD0029_1_A04
Strain type
Allele/Transgene symbolNr5a1tm1(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolNr5a1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0029_1_A04. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal pituitary gland morphology / MGI
  • abnormal hypothalamus morphology / MGI
  • abnormal testis morphology / MGI
  • Leydig cell hyperplasia / MGI
  • seminiferous tubule degeneration / MGI
  • decreased body weight / MGI
  • infertility / MGI
  • male infertility / MGI
  • female infertility / MGI
  • secondary sex reversal / MGI
  • premature death / MGI
  • abnormal reproductive system morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal innervation / MGI
  • abnormal primary sex determination / MGI
  • abnormal secondary sex determination / MGI
  • oligozoospermia / MGI
  • small adrenal glands / MGI
  • absent ovary / MGI
  • abnormal testis development / MGI
  • abnormal corticosterone level / MGI
  • decreased testis weight / MGI
  • absent adrenal gland / MGI
  • agonadal / MGI
  • absent testes / MGI
  • retention of the adrenal gland x-zone / MGI
  • decreased gonadotroph cell number / MGI
  • abnormal neuron differentiation / MGI
  • mortality/aging / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • abnormal progesterone level / MGI
  • abnormal testosterone level / MGI
  • abnormal gonadal ridge morphology / MGI
  • abnormal aldosterone level / MGI
  • abnormal ventromedial hypothalamic nucleus morphology / MGI
  • decreased ventromedial hypothalamic nucleus size / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).