C57BL/6N-Ldlrtm1a(EUCOMM)Wtsi/Ieg

Status

Available to order

EMMA IDEM:10076
International strain nameC57BL/6N-Ldlrtm1a(EUCOMM)Wtsi/Ieg
Alternative nameEPD0437_2_F04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLdlrtm1a(EUCOMM)Wtsi
Gene/Transgene symbolLdlr
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0437_2_F04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6NTac

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating cholesterol level / IMPC
  • abnormal auditory brainstem response / IMPC
  • increased mean corpuscular volume / IMPC
  • decreased circulating unsaturated transferrin level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased grip strength / IMPC
  • increased circulating iron level / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • decreased locomotor activity / IMPC
MGI phenotypes (gene matching)
  • abnormal microglial cell morphology / MGI
  • abnormal circulating cholesterol level / MGI
  • abnormal circulating LDL cholesterol level / MGI
  • increased circulating LDL cholesterol level / MGI
  • decreased circulating HDL cholesterol level / MGI
  • abnormal triglyceride level / MGI
  • alopecia / MGI
  • abnormal liver physiology / MGI
  • abnormal adrenal gland morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal CNS glial cell morphology / MGI
  • scaly skin / MGI
  • thick skin / MGI
  • obese / MGI
  • hyperactivity / MGI
  • abnormal spatial learning / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating free fatty acid level / MGI
  • increased circulating HDL cholesterol level / MGI
  • hyperglycemia / MGI
  • liver inflammation / MGI
  • abnormal glucose homeostasis / MGI
  • increased circulating insulin level / MGI
  • abnormal lipid homeostasis / MGI
  • no abnormal phenotype detected / MGI
  • abnormal astrocyte morphology / MGI
  • hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating corticosterone level / MGI
  • gallstones / MGI
  • increased circulating alanine transaminase level / MGI
  • increased liver weight / MGI
  • no phenotypic analysis / MGI
  • retinal detachment / MGI
  • amyloid beta deposits / MGI
  • liver fibrosis / MGI
  • oxidative stress / MGI
  • maternal effect / MGI
  • increased hepatocyte apoptosis / MGI
  • abnormal circulating lipid level / MGI
  • decreased lean body mass / MGI
  • increased circulating VLDL triglyceride level / MGI
  • increased cholesterol level / MGI
  • abnormal arteriole morphology / MGI
  • increased macrophage derived foam cell number / MGI
  • increased circulating VLDL cholesterol level / MGI
  • increased circulating cholesterol level / MGI
  • decreased circulating cholesterol level / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • abnormal Bruch membrane morphology / MGI
  • abnormal cholesterol homeostasis / MGI
  • impaired glucose tolerance / MGI
  • abnormal circulating amino acid level / MGI
  • insulin resistance / MGI
  • abnormal fat pad morphology / MGI
  • atherosclerotic lesions / MGI
  • increased susceptibility to atherosclerosis / MGI
  • homeostasis/metabolism phenotype / MGI
  • abnormal circulating protein level / MGI
  • increased susceptibility to weight gain / MGI
  • increased percent body fat/body weight / MGI
  • increased circulating glucose level / MGI
  • abnormal choriocapillaris morphology / MGI
  • abnormal spatial working memory / MGI
  • abnormal short term spatial reference memory / MGI
  • increased circulating tumor necrosis factor level / MGI
  • abnormal synaptic bouton morphology / MGI
  • photoreceptor outer segment degeneration / MGI
  • decreased circulating interleukin-10 level / MGI
  • increased circulating interleukin-6 level / MGI
  • increased circulating interleukin-1 beta level / MGI
  • increased liver triglyceride level / MGI
  • abnormal synapse morphology / MGI
  • increased liver cholesterol level / MGI
  • increased grip strength / MGI
  • decreased susceptibility to weight gain / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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