IMPC phenotypes (gene matching)
C57BL/6N-Sirt6tm1c(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:10067 |
| International strain name | C57BL/6N-Sirt6tm1c(EUCOMM)Wtsi/H |
| Alternative name | EPD0256_5_F08 |
| Strain type | Targeted Mutant Strains : Targeted Conditional |
| Allele/Transgene symbol | Sirt6tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Sirt6 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from EUCOMM ES clone EPD0256_5_F08, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Lethal brain and heart developmental defects / Orphanet_580933
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- malocclusion / MGI
- kyphosis / MGI
- lordosis / MGI
- hypoglycemia / MGI
- decreased leukocyte cell number / MGI
- decreased bone marrow cell number / MGI
- decreased cell proliferation / MGI
- spleen hypoplasia / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal nursing / MGI
- postnatal growth retardation / MGI
- reduced female fertility / MGI
- male infertility / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- abnormal B cell differentiation / MGI
- abnormal lymphopoiesis / MGI
- decreased circulating insulin level / MGI
- colitis / MGI
- increased insulin sensitivity / MGI
- premature aging / MGI
- spontaneous chromosome breakage / MGI
- increased cellular sensitivity to ionizing radiation / MGI
- decreased circulating insulin-like growth factor I level / MGI
- decreased double-positive T cell number / MGI
- narrow eye opening / MGI
- decreased circulating glucose level / MGI
- early cellular replicative senescence / MGI
- increased cellular sensitivity to alkylating agents / MGI
- abnormal spleen physiology / MGI
- decreased subcutaneous adipose tissue amount / MGI
- decreased total body fat amount / MGI
- lethality at weaning, complete penetrance / MGI