C57BL/6-Atm1Brd Lpar1tm1b(EUCOMM)Wtsi/Flmg

Status

Available to order

EMMA IDEM:10041
International strain nameC57BL/6-Atm1Brd Lpar1tm1b(EUCOMM)Wtsi/Flmg
Alternative nameB6-Lpar1/Flmg
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolLpar1tm1b(EUCOMM)Wtsi
Gene/Transgene symbolLpar1

Information from provider

ProviderVassilis Aidinis
Provider affiliationBSRC Alexander Fleming
Genetic informationThis allele was derived from the B6-Lpar1tm1a(EUCOMM)Wtsi/Flmg line (EMMA strain EM:09092), by removing the loxP-flanked neomycin selection cassette and exon 3 (2nd coding exon; ENSMUSE00001261995) of Lpar1 via cre-mediated recombination. The resulting allele is expressing lacZ under the control of the Lpar1 promoter. Absence of the neomycin cassette and exon 3 was confirmed by PCR.
Phenotypic informationHomozygous:
No overt phenotype

Heterozygous:
No overt phenotype
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivingheterozygous C57BL/6

Disease and phenotype information

IMPC phenotypes (allele matching)
  • cataract / IMPC
  • improved glucose tolerance / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased fasting circulating glucose level / IMPC
IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • cataract / IMPC
  • improved glucose tolerance / IMPC
  • increased fasting circulating glucose level / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal craniofacial morphology / MGI
  • short snout / MGI
  • exencephaly / MGI
  • abnormal Schwann cell morphology / MGI
  • decreased Schwann cell number / MGI
  • decreased body height / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • ocular hypertelorism / MGI
  • hypoactivity / MGI
  • abnormal suckling behavior / MGI
  • postnatal growth retardation / MGI
  • increased dopamine level / MGI
  • hemorrhage / MGI
  • abnormal sciatic nerve morphology / MGI
  • nervous system phenotype / MGI
  • long incisors / MGI
  • abnormal serotonin level / MGI
  • abnormal amino acid level / MGI
  • decreased body mass index / MGI
  • decreased prepulse inhibition / MGI
  • decreased total body fat amount / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • decreased body fat mass / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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