STOCK Parp1^{tm1a(EUCOMM)Hmgu}/IcsOrl

Status	Available to order
EMMA ID	EM:10037
International strain name	STOCK Parp1^{tm1a(EUCOMM)Hmgu}/IcsOrl
Alternative name	HEPD0555_6_C04
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Parp1^{tm1a(EUCOMM)Hmgu}
Gene/Transgene symbol	Parp1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0555_6_C04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6NCrl

Disease and phenotype information

IMPC phenotypes (gene matching)

decreased grip strength / IMPC
decreased total retina thickness / IMPC
decreased NK cell number / IMPC
preweaning lethality, incomplete penetrance / IMPC
abnormal spleen morphology / IMPC
abnormal uterus morphology / IMPC
abnormal eye morphology / IMPC
increased prepulse inhibition / IMPC
small seminal vesicle / IMPC
immune system phenotype / IMPC
increased circulating creatinine level / IMPC
increased fasting circulating glucose level / IMPC
abnormal seminal vesicle morphology / IMPC
microphthalmia / IMPC
increased effector memory CD8-positive, alpha-beta T cell number / IMPC
enlarged spleen / IMPC
abnormal retina inner nuclear layer morphology / IMPC

MGI phenotypes (gene matching)

decreased cell proliferation / MGI
skin hyperplasia / MGI
decreased body weight / MGI
increased mortality induced by gamma-irradiation / MGI
abnormal inflammatory response / MGI
decreased inflammatory response / MGI
decreased litter size / MGI
abnormal macrophage physiology / MGI
enhanced wound healing / MGI
no phenotypic analysis / MGI
abnormal leukocyte migration / MGI
decreased neuron apoptosis / MGI
abnormal response/metabolism to endogenous compounds / MGI
abnormal microglial cell physiology / MGI
elevated level of mitotic sister chromatid exchange / MGI
increased mortality induced by ionizing radiation / MGI
induced chromosome breakage / MGI
decreased susceptibility to kidney reperfusion injury / MGI
abnormal cell cycle checkpoint function / MGI
decreased susceptibility to noise-induced hearing loss / MGI
decreased susceptibility to injury / MGI
immune system phenotype / MGI
increased renal glomerular filtration rate / MGI
decreased circulating creatinine level / MGI
increased apoptosis / MGI
abnormal DNA repair / MGI
decreased circulating tumor necrosis factor level / MGI
decreased circulating interleukin-1 beta level / MGI
decreased susceptibility to endotoxin shock / MGI
decreased physiological sensitivity to xenobiotic / MGI
increased sensitivity to induced morbidity/mortality / MGI
prenatal lethality, incomplete penetrance / MGI
decreased renal tubule apoptosis / MGI
decreased susceptibility to dopaminergic neuron neurotoxicity / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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