IMPC phenotypes (allele matching)
C57BL/6N-Atm1Brd Dlg4tm1e(EUCOMM)Wtsi/WtsiCnrm
| Status | Available to order |
| EMMA ID | EM:10013 |
| International strain name | C57BL/6N-Atm1Brd Dlg4tm1e(EUCOMM)Wtsi/WtsiCnrm |
| Alternative name | EPD0677_5_B02 |
| Strain type | Targeted Mutant Strains : Targeted Non-conditional |
| Allele/Transgene symbol | Dlg4tm1e(EUCOMM)Wtsi |
| Gene/Transgene symbol | Dlg4 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0677_5_B02. For further details on the construction of this clone see the page at the IMPC portal. The targeted allele has lost the 3' loxP site. These mutations cannot be converted into conditional alleles. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
IMPC phenotypes (gene matching)
- decreased locomotor activity / IMPC
- decreased grip strength / IMPC
- decreased body weight / IMPC
- tremors / IMPC
- increased lean body mass / IMPC
- increased circulating sodium level / IMPC
- decreased exploration in new environment / IMPC
- increased bone mineral content / IMPC
- decreased total body fat amount / IMPC
- abnormal behavior / IMPC
- decreased bone mineral content / IMPC
MGI phenotypes (gene matching)
- abnormal sebaceous gland morphology / MGI
- abnormal forebrain morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal social investigation / MGI
- abnormal anxiety-related response / MGI
- increased anxiety-related response / MGI
- decreased anxiety-related response / MGI
- abnormal maternal nurturing / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- increased grooming behavior / MGI
- abnormal spatial learning / MGI
- abnormal contextual conditioning behavior / MGI
- decreased startle reflex / MGI
- impaired balance / MGI
- increased circulating corticosterone level / MGI
- abnormal pain threshold / MGI
- abnormal learning/memory/conditioning / MGI
- abnormal innervation / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal nociception after inflammation / MGI
- decreased vertical activity / MGI
- abnormal discrimination learning / MGI
- abnormal AMPA-mediated synaptic currents / MGI
- abnormal glutamate-mediated receptor currents / MGI
- abnormal NMDA-mediated synaptic currents / MGI
- enhanced paired-pulse facilitation / MGI
- enhanced long term potentiation / MGI
- allodynia / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- maternal effect / MGI
- decreased stereotypic behavior / MGI
- decreased neurotransmitter release / MGI
- abnormal striatum morphology / MGI
- abnormal synaptic plasticity / MGI
- abnormal spatial working memory / MGI
- enhanced behavioral response to cocaine / MGI
- impaired behavioral response to cocaine / MGI
- abnormal dendritic spine morphology / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased grip strength / MGI
- decreased grip strength / MGI
- increased response to stress-induced hyperthermia / MGI
- reduced AMPA-mediated synaptic currents / MGI
- postnatal lethality, incomplete penetrance / MGI
- decreased vocalization / MGI