IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
STOCK Ralatm1.2Cjm/H
| Status | Available to order |
| EMMA ID | EM:10002 |
| International strain name | STOCK Ralatm1.2Cjm/H |
| Alternative name | RalA |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Ralatm1.2Cjm |
| Gene/Transgene symbol | Rala |
Information from provider
| Provider | Afshan McCarthy |
| Provider affiliation | Cancer Biology, Institute of Cancer Research |
| Genetic information | Conditionally targeted allele of RalA. |
| Phenotypic information | Homozygous:Floxed homozygotes are healthy, fertile and have a normal life span.Heterozygous:Floxed heterozygotes are healthy, fertile and have a normal life span. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6J |
| Breeding at archiving centre | No additional breeding was done at the repository |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal inner ear morphology / MGI
- abnormal ureter morphology / MGI
- abnormal forebrain morphology / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal third ventricle morphology / MGI
- abnormal hindbrain morphology / MGI
- exencephaly / MGI
- small superior cervical ganglion / MGI
- abnormal lens morphology / MGI
- intraventricular hemorrhage / MGI
- abnormal brain morphology / MGI
- abnormal eye muscle morphology / MGI
- abnormal Mullerian duct morphology / MGI
- abnormal Wolffian duct morphology / MGI
- retroesophageal right subclavian artery / MGI
- abnormal optic stalk morphology / MGI
- fusion of vertebral arches / MGI
- coloboma / MGI
- abnormal humerus morphology / MGI
- cellular phenotype / MGI
- spinal hemorrhage / MGI
- abnormal cystic duct morphology / MGI
- abnormal spinal cord central canal morphology / MGI
- muscular ventricular septal defect / MGI
- preweaning lethality, complete penetrance / MGI
- enlarged brain ventricles / MGI
- abnormal vertebral artery morphology / MGI
- absent segment of posterior cerebral artery / MGI
- abnormal ductus venosus morphology / MGI
- abnormal ductus venosus valve morphology / MGI
- multiple persisting craniopharyngeal ducts / MGI
- reduced sympathetic cervical ganglion size / MGI
- blood in lymph vessels / MGI
- abnormal vitelline vein topology / MGI
- anastomosis between internal carotid artery and basilar artery / MGI
- abnormal vertebral artery topology / MGI
- embryo cyst / MGI
- hemangioma / MGI
- retrolental blood / MGI
Literature references
- Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis.;Peschard Pascal, McCarthy Afshan, Leblanc-Dominguez Valérie, Yeo Maggie, Guichard Sabrina, Stamp Gordon, Marshall Christopher J, ;2012;Current biology : CB;22;2063-8; 23063435