{
  "responseHeader":{
    "status":0,
    "QTime":0,
    "params":{
      "q":"do_term:\"prostate cancer\""
    }
  },
  "response":{
    "numFound":13,
    "start":0,
    "numFoundExact":true,
    "docs":[{
      "id_str":"174",
      "name_str":"129-Tgfbr2<tm1Roes>/RoesH",
      "models":["mouse"],
      "gene_symbol":"Tgfbr2",
      "do_id":["DOID:10283"],
      "do_term":["prostate cancer"],
      "mp_term":["kyphosis","abnormal erythropoiesis","enlarged pericardium","decreased embryo size","absent vitelline blood vessels","pale yolk sac","neoplasm","premature death","no abnormal phenotype detected","abnormal aorta elastic fiber morphology","abnormal vitelline vasculature morphology","abnormal embryonic hematopoiesis","increased hepatocyte proliferation","embryonic growth retardation","aortic dissection","abnormal coronary artery morphology","abnormal aortic arch morphology","increased incidence of tumors by chemical induction","hemothorax","hemopericardium","increased fatty acid level","abnormal fat pad morphology","increased total body fat amount","ascending aorta aneurysm","increased aorta wall thickness","embryonic lethality during organogenesis","complete penetrance","preweaning lethality","complete penetrance","abnormal aorta bulb morphology","dilated aorta bulb"],
      "mp_id":["MP:0000160","MP:0000245","MP:0000291","MP:0001698","MP:0001719","MP:0001722","MP:0002006","MP:0002083","MP:0002169","MP:0003211","MP:0003229","MP:0003396","MP:0003893","MP:0003984","MP:0004044","MP:0004111","MP:0004113","MP:0004499","MP:0005243","MP:0005244","MP:0005281","MP:0005334","MP:0010024","MP:0010661","MP:0010996","MP:0011098","MP:0011100","MP:0011572","MP:0011575"],
      "pheno_EMMA":"This stock carries a floxed TGF beta-receptor II gene and is without phenotype.  \r\nExcision of the floxed region of the TGF beta-receptor II gene leads to several hyper-responsive anomalies in B-cell function which are accompanied by a virtually complete IgA deficiency. This stock may have a role in studies looking at B-cell homeostasis and antigen responsiveness.",
      "_version_":1837342282479566848
    },{
      "id_str":"5566",
      "name_str":"STOCK Apc<tm2.1Cip>/Orl",
      "models":["mouse","mouse","mouse","mouse","mouse"],
      "gene_symbol":"Apc",
      "do_id":["DOID:1612","DOID:9256","DOID:684","DOID:2394","DOID:10283"],
      "do_term":["breast cancer","colorectal cancer","hepatocellular carcinoma","ovarian cancer","prostate cancer"],
      "mp_term":["absent mandible","decreased hematocrit","increased cell proliferation","abnormal digestive system morphology","gastrointestinal hemorrhage","abnormal foregut morphology","abnormal crypts of Lieberkuhn morphology","rectal prolapse","abnormal intestinal mucosa morphology","abnormal mammary gland development","mammary gland hyperplasia","abnormal brain development","abnormal floor plate morphology","abnormal ovarian folliculogenesis","abnormal ovarian follicle morphology","absent mature ovarian follicles","absent corpus luteum","abnormal vagina epithelium morphology","dermal cysts","decreased body weight","decreased body size","increased metastatic potential","abnormal nursing","hunched posture","hyperlipidemia","increased circulating triglyceride level","increased circulating free fatty acid level","anemia","extended life span","abnormal embryo development","abnormal embryo size","decreased embryo size","incomplete embryo turning","postnatal growth retardation","increased mammary adenocarcinoma incidence","neoplasm","increased pilomatricoma incidence","increased tumor incidence","increased incidence of induced tumors","increased colon adenoma incidence","premature death","abnormal developmental patterning","abnormal embryonic tissue morphology","abnormal neural tube morphology","no abnormal phenotype detected","increased intestinal adenoma incidence","hepatic steatosis","increased trichoepithelioma incidence","increased intestinal adenocarcinoma incidence","no phenotypic analysis","abnormal egg cylinder morphology","acrania","colon polyps","intestinal obstruction","melena","rectal hemorrhage","gastric polyps","increased hepatocellular carcinoma incidence","epidermal cyst","decreased tumor growth/size","abnormal tumor morphology","abnormal intestinal goblet cell morphology","increased tumor growth/size","increased osteosarcoma incidence","decreased macrophage cell number","abnormal embryonic epiblast morphology","aneuploidy","abnormal primitive node morphology","cardia bifida","increased incidence of tumors by chemical induction","split notochord","ovary atrophy","abnormal large intestine crypts of Lieberkuhn morphology","uterus atrophy","decreased T cell number","increased circulating cholesterol level","cellular phenotype","reproductive system phenotype","abnormal cell physiology","increased apoptosis","abnormal hindbrain development","absent male preputial gland","intestine polyps","increased liver tumor incidence","decreased NK cell number","abnormal anterior visceral endoderm morphology","embryonic lethality","abnormal enterocyte proliferation","adrenal gland hyperplasia","abnormal mesendoderm development","increased small intestine adenocarcinoma incidence","increased large intestine adenocarcinoma incidence","decreased splenocyte number","abnormal pregnancy","absent nipple","increased prostaglandin level","embryonic lethality between implantation and placentation","increased gastrointestinal tumor incidence","increased mammary gland tumor incidence","increased skin tumor incidence","increased stomach tumor incidence","increased osteoma incidence","increased desmoid tumor incidence","gastrointestinal tract polyps","increased adenoma incidence","altered tumor pathology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","embryonic lethality between implantation and somite formation","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","absent midbrain","embryonic-extraembryonic boundary constriction","absent forebrain","rostral-caudal axis duplication","rostral body truncation","absent neural folds","abnormal head development","decreased intestinal adenoma incidence","abnormal endocardial heart tube morphology"],
      "mp_id":["MP:0000087","MP:0000208","MP:0000351","MP:0000462","MP:0000465","MP:0000474","MP:0000490","MP:0000493","MP:0000511","MP:0000628","MP:0000630","MP:0000913","MP:0000925","MP:0001130","MP:0001131","MP:0001132","MP:0001134","MP:0001140","MP:0001247","MP:0001262","MP:0001265","MP:0001272","MP:0001382","MP:0001505","MP:0001548","MP:0001552","MP:0001554","MP:0001577","MP:0001661","MP:0001672","MP:0001697","MP:0001698","MP:0001701","MP:0001732","MP:0001883","MP:0002006","MP:0002013","MP:0002020","MP:0002021","MP:0002044","MP:0002083","MP:0002084","MP:0002085","MP:0002151","MP:0002169","MP:0002404","MP:0002628","MP:0002732","MP:0002957","MP:0003012","MP:0003085","MP:0003104","MP:0003269","MP:0003270","MP:0003292","MP:0003293","MP:0003299","MP:0003331","MP:0003414","MP:0003447","MP:0003448","MP:0003449","MP:0003721","MP:0003789","MP:0003884","MP:0003886","MP:0004024","MP:0004066","MP:0004187","MP:0004499","MP:0004713","MP:0004833","MP:0004842","MP:0004894","MP:0005018","MP:0005178","MP:0005384","MP:0005389","MP:0005621","MP:0006042","MP:0006108","MP:0006401","MP:0008011","MP:0008019","MP:0008045","MP:0008533","MP:0008762","MP:0008883","MP:0009078","MP:0009266","MP:0009309","MP:0009310","MP:0009339","MP:0009661","MP:0009733","MP:0009814","MP:0009850","MP:0010279","MP:0010299","MP:0010300","MP:0010301","MP:0010313","MP:0010338","MP:0010352","MP:0010383","MP:0010639","MP:0010768","MP:0011085","MP:0011086","MP:0011089","MP:0011091","MP:0011092","MP:0011098","MP:0011106","MP:0011109","MP:0012087","MP:0012135","MP:0012136","MP:0012156","MP:0012157","MP:0012165","MP:0012176","MP:0012434","MP:0012700"],
      "pheno_EMMA":"After cre-mediated recombination, Apc protein loses its domain required for beta-catenin degradation. Consequently, it activates a sustained beta-catenin signaling.",
      "_version_":1837342280647704576
    },{
      "id_str":"2001",
      "name_str":"B6Rcc.Cg-Cd44<tm1.1Ugu> Apc<Min>/Cnrm",
      "models":["mouse","mouse","mouse","mouse","mouse"],
      "gene_symbol":"Apc",
      "do_id":["DOID:1612","DOID:9256","DOID:684","DOID:2394","DOID:10283"],
      "do_term":["breast cancer","colorectal cancer","hepatocellular carcinoma","ovarian cancer","prostate cancer"],
      "mp_term":["absent mandible","decreased hematocrit","increased cell proliferation","abnormal digestive system morphology","gastrointestinal hemorrhage","abnormal foregut morphology","abnormal crypts of Lieberkuhn morphology","rectal prolapse","abnormal intestinal mucosa morphology","abnormal mammary gland development","mammary gland hyperplasia","abnormal brain development","abnormal floor plate morphology","abnormal ovarian folliculogenesis","abnormal ovarian follicle morphology","absent mature ovarian follicles","absent corpus luteum","abnormal vagina epithelium morphology","dermal cysts","decreased body weight","decreased body size","increased metastatic potential","abnormal nursing","hunched posture","hyperlipidemia","increased circulating triglyceride level","increased circulating free fatty acid level","anemia","extended life span","abnormal embryo development","abnormal embryo size","decreased embryo size","incomplete embryo turning","postnatal growth retardation","increased mammary adenocarcinoma incidence","neoplasm","increased pilomatricoma incidence","increased tumor incidence","increased incidence of induced tumors","increased colon adenoma incidence","premature death","abnormal developmental patterning","abnormal embryonic tissue morphology","abnormal neural tube morphology","no abnormal phenotype detected","increased intestinal adenoma incidence","hepatic steatosis","increased trichoepithelioma incidence","increased intestinal adenocarcinoma incidence","no phenotypic analysis","abnormal egg cylinder morphology","acrania","colon polyps","intestinal obstruction","melena","rectal hemorrhage","gastric polyps","increased hepatocellular carcinoma incidence","epidermal cyst","decreased tumor growth/size","abnormal tumor morphology","abnormal intestinal goblet cell morphology","increased tumor growth/size","increased osteosarcoma incidence","decreased macrophage cell number","abnormal embryonic epiblast morphology","aneuploidy","abnormal primitive node morphology","cardia bifida","increased incidence of tumors by chemical induction","split notochord","ovary atrophy","abnormal large intestine crypts of Lieberkuhn morphology","uterus atrophy","decreased T cell number","increased circulating cholesterol level","cellular phenotype","reproductive system phenotype","abnormal cell physiology","increased apoptosis","abnormal hindbrain development","absent male preputial gland","intestine polyps","increased liver tumor incidence","decreased NK cell number","abnormal anterior visceral endoderm morphology","embryonic lethality","abnormal enterocyte proliferation","adrenal gland hyperplasia","abnormal mesendoderm development","increased small intestine adenocarcinoma incidence","increased large intestine adenocarcinoma incidence","decreased splenocyte number","abnormal pregnancy","absent nipple","increased prostaglandin level","embryonic lethality between implantation and placentation","increased gastrointestinal tumor incidence","increased mammary gland tumor incidence","increased skin tumor incidence","increased stomach tumor incidence","increased osteoma incidence","increased desmoid tumor incidence","gastrointestinal tract polyps","increased adenoma incidence","altered tumor pathology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","embryonic lethality between implantation and somite formation","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","absent midbrain","embryonic-extraembryonic boundary constriction","absent forebrain","rostral-caudal axis duplication","rostral body truncation","absent neural folds","abnormal head development","decreased intestinal adenoma incidence","abnormal endocardial heart tube morphology"],
      "mp_id":["MP:0000087","MP:0000208","MP:0000351","MP:0000462","MP:0000465","MP:0000474","MP:0000490","MP:0000493","MP:0000511","MP:0000628","MP:0000630","MP:0000913","MP:0000925","MP:0001130","MP:0001131","MP:0001132","MP:0001134","MP:0001140","MP:0001247","MP:0001262","MP:0001265","MP:0001272","MP:0001382","MP:0001505","MP:0001548","MP:0001552","MP:0001554","MP:0001577","MP:0001661","MP:0001672","MP:0001697","MP:0001698","MP:0001701","MP:0001732","MP:0001883","MP:0002006","MP:0002013","MP:0002020","MP:0002021","MP:0002044","MP:0002083","MP:0002084","MP:0002085","MP:0002151","MP:0002169","MP:0002404","MP:0002628","MP:0002732","MP:0002957","MP:0003012","MP:0003085","MP:0003104","MP:0003269","MP:0003270","MP:0003292","MP:0003293","MP:0003299","MP:0003331","MP:0003414","MP:0003447","MP:0003448","MP:0003449","MP:0003721","MP:0003789","MP:0003884","MP:0003886","MP:0004024","MP:0004066","MP:0004187","MP:0004499","MP:0004713","MP:0004833","MP:0004842","MP:0004894","MP:0005018","MP:0005178","MP:0005384","MP:0005389","MP:0005621","MP:0006042","MP:0006108","MP:0006401","MP:0008011","MP:0008019","MP:0008045","MP:0008533","MP:0008762","MP:0008883","MP:0009078","MP:0009266","MP:0009309","MP:0009310","MP:0009339","MP:0009661","MP:0009733","MP:0009814","MP:0009850","MP:0010279","MP:0010299","MP:0010300","MP:0010301","MP:0010313","MP:0010338","MP:0010352","MP:0010383","MP:0010639","MP:0010768","MP:0011085","MP:0011086","MP:0011089","MP:0011091","MP:0011092","MP:0011098","MP:0011106","MP:0011109","MP:0012087","MP:0012135","MP:0012136","MP:0012156","MP:0012157","MP:0012165","MP:0012176","MP:0012434","MP:0012700"],
      "pheno_EMMA":"Min/+: Development of early stages of colon carcinoma: polyps. \r\nCd44v6v7-/-: Expression of Cd44v6 is an independent prognostic factor for a poor prognosis in colon carcinoma.\tExpression of Cd44v6 isoforms has been shown to be an independent prognostic factor for a poor prognosis in human colon carcinoma (Mulder et al., 1994). To determine whether and to what extent Cd44v6/v7-containing isoforms are involved in the early stages of adenoma formation, we crossbred Apc<Min> mice with mice bearing deletions for Cd44v6/v7.  While Min/+ x Cd44v6/v7 wild-type mice developed on the average more than 50 adenomas at an age of 12-18 weeks, Min/+ x Cd44v6/v7 knock-out mice developed fewer than 10 adenomas, and many had no polyps at all.  Moreover, the life span of Min/+ x Cd44v6/v7 null mice increased substantially to more than 60 weeks (p<0.000001).",
      "_version_":1837342281784360960
    },{
      "id_str":"2000",
      "name_str":"B6Rcc.B6J-Apc<Min>/Cnrm",
      "models":["mouse","mouse","mouse","mouse","mouse"],
      "gene_symbol":"Apc",
      "do_id":["DOID:1612","DOID:9256","DOID:684","DOID:2394","DOID:10283"],
      "do_term":["breast cancer","colorectal cancer","hepatocellular carcinoma","ovarian cancer","prostate cancer"],
      "mp_term":["absent mandible","decreased hematocrit","increased cell proliferation","abnormal digestive system morphology","gastrointestinal hemorrhage","abnormal foregut morphology","abnormal crypts of Lieberkuhn morphology","rectal prolapse","abnormal intestinal mucosa morphology","abnormal mammary gland development","mammary gland hyperplasia","abnormal brain development","abnormal floor plate morphology","abnormal ovarian folliculogenesis","abnormal ovarian follicle morphology","absent mature ovarian follicles","absent corpus luteum","abnormal vagina epithelium morphology","dermal cysts","decreased body weight","decreased body size","increased metastatic potential","abnormal nursing","hunched posture","hyperlipidemia","increased circulating triglyceride level","increased circulating free fatty acid level","anemia","extended life span","abnormal embryo development","abnormal embryo size","decreased embryo size","incomplete embryo turning","postnatal growth retardation","increased mammary adenocarcinoma incidence","neoplasm","increased pilomatricoma incidence","increased tumor incidence","increased incidence of induced tumors","increased colon adenoma incidence","premature death","abnormal developmental patterning","abnormal embryonic tissue morphology","abnormal neural tube morphology","no abnormal phenotype detected","increased intestinal adenoma incidence","hepatic steatosis","increased trichoepithelioma incidence","increased intestinal adenocarcinoma incidence","no phenotypic analysis","abnormal egg cylinder morphology","acrania","colon polyps","intestinal obstruction","melena","rectal hemorrhage","gastric polyps","increased hepatocellular carcinoma incidence","epidermal cyst","decreased tumor growth/size","abnormal tumor morphology","abnormal intestinal goblet cell morphology","increased tumor growth/size","increased osteosarcoma incidence","decreased macrophage cell number","abnormal embryonic epiblast morphology","aneuploidy","abnormal primitive node morphology","cardia bifida","increased incidence of tumors by chemical induction","split notochord","ovary atrophy","abnormal large intestine crypts of Lieberkuhn morphology","uterus atrophy","decreased T cell number","increased circulating cholesterol level","cellular phenotype","reproductive system phenotype","abnormal cell physiology","increased apoptosis","abnormal hindbrain development","absent male preputial gland","intestine polyps","increased liver tumor incidence","decreased NK cell number","abnormal anterior visceral endoderm morphology","embryonic lethality","abnormal enterocyte proliferation","adrenal gland hyperplasia","abnormal mesendoderm development","increased small intestine adenocarcinoma incidence","increased large intestine adenocarcinoma incidence","decreased splenocyte number","abnormal pregnancy","absent nipple","increased prostaglandin level","embryonic lethality between implantation and placentation","increased gastrointestinal tumor incidence","increased mammary gland tumor incidence","increased skin tumor incidence","increased stomach tumor incidence","increased osteoma incidence","increased desmoid tumor incidence","gastrointestinal tract polyps","increased adenoma incidence","altered tumor pathology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","embryonic lethality between implantation and somite formation","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","absent midbrain","embryonic-extraembryonic boundary constriction","absent forebrain","rostral-caudal axis duplication","rostral body truncation","absent neural folds","abnormal head development","decreased intestinal adenoma incidence","abnormal endocardial heart tube morphology"],
      "mp_id":["MP:0000087","MP:0000208","MP:0000351","MP:0000462","MP:0000465","MP:0000474","MP:0000490","MP:0000493","MP:0000511","MP:0000628","MP:0000630","MP:0000913","MP:0000925","MP:0001130","MP:0001131","MP:0001132","MP:0001134","MP:0001140","MP:0001247","MP:0001262","MP:0001265","MP:0001272","MP:0001382","MP:0001505","MP:0001548","MP:0001552","MP:0001554","MP:0001577","MP:0001661","MP:0001672","MP:0001697","MP:0001698","MP:0001701","MP:0001732","MP:0001883","MP:0002006","MP:0002013","MP:0002020","MP:0002021","MP:0002044","MP:0002083","MP:0002084","MP:0002085","MP:0002151","MP:0002169","MP:0002404","MP:0002628","MP:0002732","MP:0002957","MP:0003012","MP:0003085","MP:0003104","MP:0003269","MP:0003270","MP:0003292","MP:0003293","MP:0003299","MP:0003331","MP:0003414","MP:0003447","MP:0003448","MP:0003449","MP:0003721","MP:0003789","MP:0003884","MP:0003886","MP:0004024","MP:0004066","MP:0004187","MP:0004499","MP:0004713","MP:0004833","MP:0004842","MP:0004894","MP:0005018","MP:0005178","MP:0005384","MP:0005389","MP:0005621","MP:0006042","MP:0006108","MP:0006401","MP:0008011","MP:0008019","MP:0008045","MP:0008533","MP:0008762","MP:0008883","MP:0009078","MP:0009266","MP:0009309","MP:0009310","MP:0009339","MP:0009661","MP:0009733","MP:0009814","MP:0009850","MP:0010279","MP:0010299","MP:0010300","MP:0010301","MP:0010313","MP:0010338","MP:0010352","MP:0010383","MP:0010639","MP:0010768","MP:0011085","MP:0011086","MP:0011089","MP:0011091","MP:0011092","MP:0011098","MP:0011106","MP:0011109","MP:0012087","MP:0012135","MP:0012136","MP:0012156","MP:0012157","MP:0012165","MP:0012176","MP:0012434","MP:0012700"],
      "pheno_EMMA":"Min/+: development of early stages of colon carcinoma, polyps.",
      "_version_":1837342281815818240
    },{
      "id_str":"2002",
      "name_str":"B6Rcc.Cg-Spp1<tm1Rit> Apc<Min>/Cnrm",
      "models":["mouse","mouse","mouse","mouse","mouse"],
      "gene_symbol":"Apc",
      "do_id":["DOID:1612","DOID:9256","DOID:684","DOID:2394","DOID:10283"],
      "do_term":["breast cancer","colorectal cancer","hepatocellular carcinoma","ovarian cancer","prostate cancer"],
      "mp_term":["absent mandible","decreased hematocrit","increased cell proliferation","abnormal digestive system morphology","gastrointestinal hemorrhage","abnormal foregut morphology","abnormal crypts of Lieberkuhn morphology","rectal prolapse","abnormal intestinal mucosa morphology","abnormal mammary gland development","mammary gland hyperplasia","abnormal brain development","abnormal floor plate morphology","abnormal ovarian folliculogenesis","abnormal ovarian follicle morphology","absent mature ovarian follicles","absent corpus luteum","abnormal vagina epithelium morphology","dermal cysts","decreased body weight","decreased body size","increased metastatic potential","abnormal nursing","hunched posture","hyperlipidemia","increased circulating triglyceride level","increased circulating free fatty acid level","anemia","extended life span","abnormal embryo development","abnormal embryo size","decreased embryo size","incomplete embryo turning","postnatal growth retardation","increased mammary adenocarcinoma incidence","neoplasm","increased pilomatricoma incidence","increased tumor incidence","increased incidence of induced tumors","increased colon adenoma incidence","premature death","abnormal developmental patterning","abnormal embryonic tissue morphology","abnormal neural tube morphology","no abnormal phenotype detected","increased intestinal adenoma incidence","hepatic steatosis","increased trichoepithelioma incidence","increased intestinal adenocarcinoma incidence","no phenotypic analysis","abnormal egg cylinder morphology","acrania","colon polyps","intestinal obstruction","melena","rectal hemorrhage","gastric polyps","increased hepatocellular carcinoma incidence","epidermal cyst","decreased tumor growth/size","abnormal tumor morphology","abnormal intestinal goblet cell morphology","increased tumor growth/size","increased osteosarcoma incidence","decreased macrophage cell number","abnormal embryonic epiblast morphology","aneuploidy","abnormal primitive node morphology","cardia bifida","increased incidence of tumors by chemical induction","split notochord","ovary atrophy","abnormal large intestine crypts of Lieberkuhn morphology","uterus atrophy","decreased T cell number","increased circulating cholesterol level","cellular phenotype","reproductive system phenotype","abnormal cell physiology","increased apoptosis","abnormal hindbrain development","absent male preputial gland","intestine polyps","increased liver tumor incidence","decreased NK cell number","abnormal anterior visceral endoderm morphology","embryonic lethality","abnormal enterocyte proliferation","adrenal gland hyperplasia","abnormal mesendoderm development","increased small intestine adenocarcinoma incidence","increased large intestine adenocarcinoma incidence","decreased splenocyte number","abnormal pregnancy","absent nipple","increased prostaglandin level","embryonic lethality between implantation and placentation","increased gastrointestinal tumor incidence","increased mammary gland tumor incidence","increased skin tumor incidence","increased stomach tumor incidence","increased osteoma incidence","increased desmoid tumor incidence","gastrointestinal tract polyps","increased adenoma incidence","altered tumor pathology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","embryonic lethality between implantation and somite formation","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","absent midbrain","embryonic-extraembryonic boundary constriction","absent forebrain","rostral-caudal axis duplication","rostral body truncation","absent neural folds","abnormal head development","decreased intestinal adenoma incidence","abnormal endocardial heart tube morphology"],
      "mp_id":["MP:0000087","MP:0000208","MP:0000351","MP:0000462","MP:0000465","MP:0000474","MP:0000490","MP:0000493","MP:0000511","MP:0000628","MP:0000630","MP:0000913","MP:0000925","MP:0001130","MP:0001131","MP:0001132","MP:0001134","MP:0001140","MP:0001247","MP:0001262","MP:0001265","MP:0001272","MP:0001382","MP:0001505","MP:0001548","MP:0001552","MP:0001554","MP:0001577","MP:0001661","MP:0001672","MP:0001697","MP:0001698","MP:0001701","MP:0001732","MP:0001883","MP:0002006","MP:0002013","MP:0002020","MP:0002021","MP:0002044","MP:0002083","MP:0002084","MP:0002085","MP:0002151","MP:0002169","MP:0002404","MP:0002628","MP:0002732","MP:0002957","MP:0003012","MP:0003085","MP:0003104","MP:0003269","MP:0003270","MP:0003292","MP:0003293","MP:0003299","MP:0003331","MP:0003414","MP:0003447","MP:0003448","MP:0003449","MP:0003721","MP:0003789","MP:0003884","MP:0003886","MP:0004024","MP:0004066","MP:0004187","MP:0004499","MP:0004713","MP:0004833","MP:0004842","MP:0004894","MP:0005018","MP:0005178","MP:0005384","MP:0005389","MP:0005621","MP:0006042","MP:0006108","MP:0006401","MP:0008011","MP:0008019","MP:0008045","MP:0008533","MP:0008762","MP:0008883","MP:0009078","MP:0009266","MP:0009309","MP:0009310","MP:0009339","MP:0009661","MP:0009733","MP:0009814","MP:0009850","MP:0010279","MP:0010299","MP:0010300","MP:0010301","MP:0010313","MP:0010338","MP:0010352","MP:0010383","MP:0010639","MP:0010768","MP:0011085","MP:0011086","MP:0011089","MP:0011091","MP:0011092","MP:0011098","MP:0011106","MP:0011109","MP:0012087","MP:0012135","MP:0012136","MP:0012156","MP:0012157","MP:0012165","MP:0012176","MP:0012434","MP:0012700"],
      "pheno_EMMA":"Min/+: development of early stages of colon carcinoma: polyps. \t\r\nSpp1 (Opn) -/-: influence on colon carcinoma not known.",
      "_version_":1837342282578132992
    },{
      "id_str":"1715",
      "name_str":"C57BL/6J-Apc<Min>/2H",
      "models":["mouse","mouse","mouse","mouse","mouse"],
      "gene_symbol":"Apc",
      "do_id":["DOID:1612","DOID:9256","DOID:684","DOID:2394","DOID:10283"],
      "do_term":["breast cancer","colorectal cancer","hepatocellular carcinoma","ovarian cancer","prostate cancer"],
      "mp_term":["absent mandible","decreased hematocrit","increased cell proliferation","abnormal digestive system morphology","gastrointestinal hemorrhage","abnormal foregut morphology","abnormal crypts of Lieberkuhn morphology","rectal prolapse","abnormal intestinal mucosa morphology","abnormal mammary gland development","mammary gland hyperplasia","abnormal brain development","abnormal floor plate morphology","abnormal ovarian folliculogenesis","abnormal ovarian follicle morphology","absent mature ovarian follicles","absent corpus luteum","abnormal vagina epithelium morphology","dermal cysts","decreased body weight","decreased body size","increased metastatic potential","abnormal nursing","hunched posture","hyperlipidemia","increased circulating triglyceride level","increased circulating free fatty acid level","anemia","extended life span","abnormal embryo development","abnormal embryo size","decreased embryo size","incomplete embryo turning","postnatal growth retardation","increased mammary adenocarcinoma incidence","neoplasm","increased pilomatricoma incidence","increased tumor incidence","increased incidence of induced tumors","increased colon adenoma incidence","premature death","abnormal developmental patterning","abnormal embryonic tissue morphology","abnormal neural tube morphology","no abnormal phenotype detected","increased intestinal adenoma incidence","hepatic steatosis","increased trichoepithelioma incidence","increased intestinal adenocarcinoma incidence","no phenotypic analysis","abnormal egg cylinder morphology","acrania","colon polyps","intestinal obstruction","melena","rectal hemorrhage","gastric polyps","increased hepatocellular carcinoma incidence","epidermal cyst","decreased tumor growth/size","abnormal tumor morphology","abnormal intestinal goblet cell morphology","increased tumor growth/size","increased osteosarcoma incidence","decreased macrophage cell number","abnormal embryonic epiblast morphology","aneuploidy","abnormal primitive node morphology","cardia bifida","increased incidence of tumors by chemical induction","split notochord","ovary atrophy","abnormal large intestine crypts of Lieberkuhn morphology","uterus atrophy","decreased T cell number","increased circulating cholesterol level","cellular phenotype","reproductive system phenotype","abnormal cell physiology","increased apoptosis","abnormal hindbrain development","absent male preputial gland","intestine polyps","increased liver tumor incidence","decreased NK cell number","abnormal anterior visceral endoderm morphology","embryonic lethality","abnormal enterocyte proliferation","adrenal gland hyperplasia","abnormal mesendoderm development","increased small intestine adenocarcinoma incidence","increased large intestine adenocarcinoma incidence","decreased splenocyte number","abnormal pregnancy","absent nipple","increased prostaglandin level","embryonic lethality between implantation and placentation","increased gastrointestinal tumor incidence","increased mammary gland tumor incidence","increased skin tumor incidence","increased stomach tumor incidence","increased osteoma incidence","increased desmoid tumor incidence","gastrointestinal tract polyps","increased adenoma incidence","altered tumor pathology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","embryonic lethality between implantation and somite formation","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","absent midbrain","embryonic-extraembryonic boundary constriction","absent forebrain","rostral-caudal axis duplication","rostral body truncation","absent neural folds","abnormal head development","decreased intestinal adenoma incidence","abnormal endocardial heart tube morphology"],
      "mp_id":["MP:0000087","MP:0000208","MP:0000351","MP:0000462","MP:0000465","MP:0000474","MP:0000490","MP:0000493","MP:0000511","MP:0000628","MP:0000630","MP:0000913","MP:0000925","MP:0001130","MP:0001131","MP:0001132","MP:0001134","MP:0001140","MP:0001247","MP:0001262","MP:0001265","MP:0001272","MP:0001382","MP:0001505","MP:0001548","MP:0001552","MP:0001554","MP:0001577","MP:0001661","MP:0001672","MP:0001697","MP:0001698","MP:0001701","MP:0001732","MP:0001883","MP:0002006","MP:0002013","MP:0002020","MP:0002021","MP:0002044","MP:0002083","MP:0002084","MP:0002085","MP:0002151","MP:0002169","MP:0002404","MP:0002628","MP:0002732","MP:0002957","MP:0003012","MP:0003085","MP:0003104","MP:0003269","MP:0003270","MP:0003292","MP:0003293","MP:0003299","MP:0003331","MP:0003414","MP:0003447","MP:0003448","MP:0003449","MP:0003721","MP:0003789","MP:0003884","MP:0003886","MP:0004024","MP:0004066","MP:0004187","MP:0004499","MP:0004713","MP:0004833","MP:0004842","MP:0004894","MP:0005018","MP:0005178","MP:0005384","MP:0005389","MP:0005621","MP:0006042","MP:0006108","MP:0006401","MP:0008011","MP:0008019","MP:0008045","MP:0008533","MP:0008762","MP:0008883","MP:0009078","MP:0009266","MP:0009309","MP:0009310","MP:0009339","MP:0009661","MP:0009733","MP:0009814","MP:0009850","MP:0010279","MP:0010299","MP:0010300","MP:0010301","MP:0010313","MP:0010338","MP:0010352","MP:0010383","MP:0010639","MP:0010768","MP:0011085","MP:0011086","MP:0011089","MP:0011091","MP:0011092","MP:0011098","MP:0011106","MP:0011109","MP:0012087","MP:0012135","MP:0012136","MP:0012156","MP:0012157","MP:0012165","MP:0012176","MP:0012434","MP:0012700"],
      "pheno_EMMA":"Resistance to intestinal tumours.",
      "_version_":1837342282794139648
    },{
      "id_str":"78",
      "name_str":"C3.Cg-Ctnnb1<Bfc>/H",
      "models":["human/mouse","mouse","mouse","mouse"],
      "gene_symbol":"Ctnnb1",
      "do_id":["DOID:2394","DOID:2999","DOID:10283","DOID:11054"],
      "do_term":["ovarian cancer","granulosa cell tumor","prostate cancer","urinary bladder cancer"],
      "mp_term":["growth retardation of molars","increased leukocyte cell number","increased granulocyte number","broad head","abnormal coat/ hair morphology","absent hair follicles","decreased hair follicle number","alopecia","abnormal head morphology","microcephaly","abnormal cranium morphology","domed cranium","flattened snout","gastrointestinal hemorrhage","abnormal small intestine morphology","abnormal foot pad morphology","kinked tail","abnormal sweat gland morphology","tremors","abnormal tongue morphology","decreased corpus callosum size","forebrain hypoplasia","small cerebellum","decreased body size","sparse vibrissae","anophthalmia","microphthalmia","ocular hypertelorism","cataract","dry eyes","impaired coordination","reduced long term potentiation","hunched posture","abnormal coat appearance","impaired balance","abnormal vocalization","abnormal germ layer development","abnormal ectoderm development","abnormal mesoderm development","absent mesoderm","abnormal gastrulation","failure to gastrulate","decreased embryo size","abnormal proximal-distal axis patterning","absent amniotic folds","increased inflammatory response","increased susceptibility to otitis media","conjunctivitis","decreased litter size","deafness","blindness","abnormal hair growth","premature death","abnormal developmental patterning","abnormal extraembryonic tissue morphology","abnormal eye morphology","no abnormal phenotype detected","abnormal cervical lymph node morphology","increased intestinal adenoma incidence","abnormal macrophage physiology","abnormal inner cell mass morphology","small olfactory bulb","abnormal operant conditioning behavior","absent Peyer's patches","increased intestinal adenocarcinoma incidence","no phenotypic analysis","absent allantois","early eyelid opening","abnormal forebrain development","abnormal intestinal goblet cell morphology","abnormal hair follicle development","abnormal embryonic epiblast morphology","increased hepatocyte apoptosis","liver hemorrhage","abnormal craniofacial development","abnormal nitric oxide homeostasis","embryonic growth retardation","abnormal globus pallidus morphology","absent maxilla","abnormal nasal capsule morphology","abnormal synaptic vesicle clustering","short incisors","increased susceptibility to parasitic infection","lethargy","abnormal rostral-caudal axis patterning","increased brain size","narrow eye opening","abnormal corneal stroma morphology","growth retardation of incisors","abnormal corneal epithelium morphology","absent Meibomian glands","small pharyngeal arch","small molars","decreased Peyer's patch number","small Peyer's patches","abnormal spatial reference memory","abnormal peripheral lymph node morphology","absent peripheral lymph nodes","facial cleft","decreased prepulse inhibition","impaired contextual conditioning behavior","small brachial lymph nodes","small axillary lymph nodes","absent popliteal lymph nodes","abnormal hippocampus neuron morphology","abnormal vibrissa follicle morphology","increased gastrointestinal tumor incidence","abnormal mandibular prominence morphology","abnormal maxillary prominence morphology","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality between implantation and somite formation","complete penetrance","embryonic lethality during organogenesis","complete penetrance","preweaning lethality","complete penetrance","prenatal lethality","incomplete penetrance","preweaning lethality","incomplete penetrance","increased hair follicle apoptosis","abnormal head size","increased striatum area","Harderian gland atrophy","keratoconjunctivitis sicca","abnormal eyelid margin morphology","enlarged thalamus","abnormal anterior head development","misaligned incisors"],
      "mp_id":["MP:0000128","MP:0000218","MP:0000322","MP:0000346","MP:0000367","MP:0000378","MP:0000379","MP:0000414","MP:0000432","MP:0000433","MP:0000438","MP:0000440","MP:0000447","MP:0000465","MP:0000496","MP:0000574","MP:0000585","MP:0000674","MP:0000745","MP:0000762","MP:0000781","MP:0000784","MP:0000852","MP:0001265","MP:0001283","MP:0001293","MP:0001297","MP:0001300","MP:0001304","MP:0001337","MP:0001405","MP:0001473","MP:0001505","MP:0001510","MP:0001525","MP:0001529","MP:0001674","MP:0001675","MP:0001680","MP:0001683","MP:0001695","MP:0001696","MP:0001698","MP:0001705","MP:0001710","MP:0001846","MP:0001850","MP:0001852","MP:0001935","MP:0001967","MP:0002001","MP:0002073","MP:0002083","MP:0002084","MP:0002086","MP:0002092","MP:0002169","MP:0002351","MP:0002404","MP:0002451","MP:0002718","MP:0002741","MP:0002803","MP:0002831","MP:0002957","MP:0003012","MP:0003087","MP:0003153","MP:0003232","MP:0003449","MP:0003704","MP:0003886","MP:0003887","MP:0003888","MP:0003935","MP:0003957","MP:0003984","MP:0004081","MP:0004539","MP:0004726","MP:0004793","MP:0004830","MP:0005027","MP:0005202","MP:0005221","MP:0005238","MP:0005287","MP:0005300","MP:0005359","MP:0006000","MP:0006236","MP:0006346","MP:0006402","MP:0008133","MP:0008135","MP:0008414","MP:0008463","MP:0008464","MP:0008797","MP:0009142","MP:0009454","MP:0009629","MP:0009632","MP:0009634","MP:0009939","MP:0010234","MP:0010279","MP:0010939","MP:0010940","MP:0011089","MP:0011091","MP:0011092","MP:0011096","MP:0011098","MP:0011100","MP:0011101","MP:0011110","MP:0011195","MP:0011496","MP:0012467","MP:0013445","MP:0013466","MP:0013745","MP:0020526","MP:0030324","MP:0030541"],
      "pheno_EMMA":"Short broad head, dark pigmentation, abnormal gait and pelvic elevation. Mice heterozygous for this mutation have abnormal facial pigmentation, craniofacial abnormalities observed as broad head and skeletal abnormalities observed as an abnormal gait and elevated pelvis.",
      "_version_":1837342283039506432
    },{
      "id_str":"13037",
      "name_str":"C57BL/6J-Ctnnb1<em1H>/H",
      "models":["human/mouse","mouse","mouse","mouse"],
      "gene_symbol":"Ctnnb1",
      "do_id":["DOID:2394","DOID:2999","DOID:10283","DOID:11054"],
      "do_term":["ovarian cancer","granulosa cell tumor","prostate cancer","urinary bladder cancer"],
      "mp_term":["growth retardation of molars","increased leukocyte cell number","increased granulocyte number","broad head","abnormal coat/ hair morphology","absent hair follicles","decreased hair follicle number","alopecia","abnormal head morphology","microcephaly","abnormal cranium morphology","domed cranium","flattened snout","gastrointestinal hemorrhage","abnormal small intestine morphology","abnormal foot pad morphology","kinked tail","abnormal sweat gland morphology","tremors","abnormal tongue morphology","decreased corpus callosum size","forebrain hypoplasia","small cerebellum","decreased body size","sparse vibrissae","anophthalmia","microphthalmia","ocular hypertelorism","cataract","dry eyes","impaired coordination","reduced long term potentiation","hunched posture","abnormal coat appearance","impaired balance","abnormal vocalization","abnormal germ layer development","abnormal ectoderm development","abnormal mesoderm development","absent mesoderm","abnormal gastrulation","failure to gastrulate","decreased embryo size","abnormal proximal-distal axis patterning","absent amniotic folds","increased inflammatory response","increased susceptibility to otitis media","conjunctivitis","decreased litter size","deafness","blindness","abnormal hair growth","premature death","abnormal developmental patterning","abnormal extraembryonic tissue morphology","abnormal eye morphology","no abnormal phenotype detected","abnormal cervical lymph node morphology","increased intestinal adenoma incidence","abnormal macrophage physiology","abnormal inner cell mass morphology","small olfactory bulb","abnormal operant conditioning behavior","absent Peyer's patches","increased intestinal adenocarcinoma incidence","no phenotypic analysis","absent allantois","early eyelid opening","abnormal forebrain development","abnormal intestinal goblet cell morphology","abnormal hair follicle development","abnormal embryonic epiblast morphology","increased hepatocyte apoptosis","liver hemorrhage","abnormal craniofacial development","abnormal nitric oxide homeostasis","embryonic growth retardation","abnormal globus pallidus morphology","absent maxilla","abnormal nasal capsule morphology","abnormal synaptic vesicle clustering","short incisors","increased susceptibility to parasitic infection","lethargy","abnormal rostral-caudal axis patterning","increased brain size","narrow eye opening","abnormal corneal stroma morphology","growth retardation of incisors","abnormal corneal epithelium morphology","absent Meibomian glands","small pharyngeal arch","small molars","decreased Peyer's patch number","small Peyer's patches","abnormal spatial reference memory","abnormal peripheral lymph node morphology","absent peripheral lymph nodes","facial cleft","decreased prepulse inhibition","impaired contextual conditioning behavior","small brachial lymph nodes","small axillary lymph nodes","absent popliteal lymph nodes","abnormal hippocampus neuron morphology","abnormal vibrissa follicle morphology","increased gastrointestinal tumor incidence","abnormal mandibular prominence morphology","abnormal maxillary prominence morphology","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality between implantation and somite formation","complete penetrance","embryonic lethality during organogenesis","complete penetrance","preweaning lethality","complete penetrance","prenatal lethality","incomplete penetrance","preweaning lethality","incomplete penetrance","increased hair follicle apoptosis","abnormal head size","increased striatum area","Harderian gland atrophy","keratoconjunctivitis sicca","abnormal eyelid margin morphology","enlarged thalamus","abnormal anterior head development","misaligned incisors"],
      "mp_id":["MP:0000128","MP:0000218","MP:0000322","MP:0000346","MP:0000367","MP:0000378","MP:0000379","MP:0000414","MP:0000432","MP:0000433","MP:0000438","MP:0000440","MP:0000447","MP:0000465","MP:0000496","MP:0000574","MP:0000585","MP:0000674","MP:0000745","MP:0000762","MP:0000781","MP:0000784","MP:0000852","MP:0001265","MP:0001283","MP:0001293","MP:0001297","MP:0001300","MP:0001304","MP:0001337","MP:0001405","MP:0001473","MP:0001505","MP:0001510","MP:0001525","MP:0001529","MP:0001674","MP:0001675","MP:0001680","MP:0001683","MP:0001695","MP:0001696","MP:0001698","MP:0001705","MP:0001710","MP:0001846","MP:0001850","MP:0001852","MP:0001935","MP:0001967","MP:0002001","MP:0002073","MP:0002083","MP:0002084","MP:0002086","MP:0002092","MP:0002169","MP:0002351","MP:0002404","MP:0002451","MP:0002718","MP:0002741","MP:0002803","MP:0002831","MP:0002957","MP:0003012","MP:0003087","MP:0003153","MP:0003232","MP:0003449","MP:0003704","MP:0003886","MP:0003887","MP:0003888","MP:0003935","MP:0003957","MP:0003984","MP:0004081","MP:0004539","MP:0004726","MP:0004793","MP:0004830","MP:0005027","MP:0005202","MP:0005221","MP:0005238","MP:0005287","MP:0005300","MP:0005359","MP:0006000","MP:0006236","MP:0006346","MP:0006402","MP:0008133","MP:0008135","MP:0008414","MP:0008463","MP:0008464","MP:0008797","MP:0009142","MP:0009454","MP:0009629","MP:0009632","MP:0009634","MP:0009939","MP:0010234","MP:0010279","MP:0010939","MP:0010940","MP:0011089","MP:0011091","MP:0011092","MP:0011096","MP:0011098","MP:0011100","MP:0011101","MP:0011110","MP:0011195","MP:0011496","MP:0012467","MP:0013445","MP:0013466","MP:0013745","MP:0020526","MP:0030324","MP:0030541"],
      "pheno_EMMA":"Unknown",
      "_version_":1837342283454742528
    },{
      "id_str":"1724",
      "name_str":"C57BL/6J-Apc<Min>/5H",
      "models":["mouse","mouse","mouse","mouse","mouse"],
      "gene_symbol":"Apc",
      "do_id":["DOID:1612","DOID:9256","DOID:684","DOID:2394","DOID:10283"],
      "do_term":["breast cancer","colorectal cancer","hepatocellular carcinoma","ovarian cancer","prostate cancer"],
      "mp_term":["absent mandible","decreased hematocrit","increased cell proliferation","abnormal digestive system morphology","gastrointestinal hemorrhage","abnormal foregut morphology","abnormal crypts of Lieberkuhn morphology","rectal prolapse","abnormal intestinal mucosa morphology","abnormal mammary gland development","mammary gland hyperplasia","abnormal brain development","abnormal floor plate morphology","abnormal ovarian folliculogenesis","abnormal ovarian follicle morphology","absent mature ovarian follicles","absent corpus luteum","abnormal vagina epithelium morphology","dermal cysts","decreased body weight","decreased body size","increased metastatic potential","abnormal nursing","hunched posture","hyperlipidemia","increased circulating triglyceride level","increased circulating free fatty acid level","anemia","extended life span","abnormal embryo development","abnormal embryo size","decreased embryo size","incomplete embryo turning","postnatal growth retardation","increased mammary adenocarcinoma incidence","neoplasm","increased pilomatricoma incidence","increased tumor incidence","increased incidence of induced tumors","increased colon adenoma incidence","premature death","abnormal developmental patterning","abnormal embryonic tissue morphology","abnormal neural tube morphology","no abnormal phenotype detected","increased intestinal adenoma incidence","hepatic steatosis","increased trichoepithelioma incidence","increased intestinal adenocarcinoma incidence","no phenotypic analysis","abnormal egg cylinder morphology","acrania","colon polyps","intestinal obstruction","melena","rectal hemorrhage","gastric polyps","increased hepatocellular carcinoma incidence","epidermal cyst","decreased tumor growth/size","abnormal tumor morphology","abnormal intestinal goblet cell morphology","increased tumor growth/size","increased osteosarcoma incidence","decreased macrophage cell number","abnormal embryonic epiblast morphology","aneuploidy","abnormal primitive node morphology","cardia bifida","increased incidence of tumors by chemical induction","split notochord","ovary atrophy","abnormal large intestine crypts of Lieberkuhn morphology","uterus atrophy","decreased T cell number","increased circulating cholesterol level","cellular phenotype","reproductive system phenotype","abnormal cell physiology","increased apoptosis","abnormal hindbrain development","absent male preputial gland","intestine polyps","increased liver tumor incidence","decreased NK cell number","abnormal anterior visceral endoderm morphology","embryonic lethality","abnormal enterocyte proliferation","adrenal gland hyperplasia","abnormal mesendoderm development","increased small intestine adenocarcinoma incidence","increased large intestine adenocarcinoma incidence","decreased splenocyte number","abnormal pregnancy","absent nipple","increased prostaglandin level","embryonic lethality between implantation and placentation","increased gastrointestinal tumor incidence","increased mammary gland tumor incidence","increased skin tumor incidence","increased stomach tumor incidence","increased osteoma incidence","increased desmoid tumor incidence","gastrointestinal tract polyps","increased adenoma incidence","altered tumor pathology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","perinatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","embryonic lethality between implantation and somite formation","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","absent midbrain","embryonic-extraembryonic boundary constriction","absent forebrain","rostral-caudal axis duplication","rostral body truncation","absent neural folds","abnormal head development","decreased intestinal adenoma incidence","abnormal endocardial heart tube morphology"],
      "mp_id":["MP:0000087","MP:0000208","MP:0000351","MP:0000462","MP:0000465","MP:0000474","MP:0000490","MP:0000493","MP:0000511","MP:0000628","MP:0000630","MP:0000913","MP:0000925","MP:0001130","MP:0001131","MP:0001132","MP:0001134","MP:0001140","MP:0001247","MP:0001262","MP:0001265","MP:0001272","MP:0001382","MP:0001505","MP:0001548","MP:0001552","MP:0001554","MP:0001577","MP:0001661","MP:0001672","MP:0001697","MP:0001698","MP:0001701","MP:0001732","MP:0001883","MP:0002006","MP:0002013","MP:0002020","MP:0002021","MP:0002044","MP:0002083","MP:0002084","MP:0002085","MP:0002151","MP:0002169","MP:0002404","MP:0002628","MP:0002732","MP:0002957","MP:0003012","MP:0003085","MP:0003104","MP:0003269","MP:0003270","MP:0003292","MP:0003293","MP:0003299","MP:0003331","MP:0003414","MP:0003447","MP:0003448","MP:0003449","MP:0003721","MP:0003789","MP:0003884","MP:0003886","MP:0004024","MP:0004066","MP:0004187","MP:0004499","MP:0004713","MP:0004833","MP:0004842","MP:0004894","MP:0005018","MP:0005178","MP:0005384","MP:0005389","MP:0005621","MP:0006042","MP:0006108","MP:0006401","MP:0008011","MP:0008019","MP:0008045","MP:0008533","MP:0008762","MP:0008883","MP:0009078","MP:0009266","MP:0009309","MP:0009310","MP:0009339","MP:0009661","MP:0009733","MP:0009814","MP:0009850","MP:0010279","MP:0010299","MP:0010300","MP:0010301","MP:0010313","MP:0010338","MP:0010352","MP:0010383","MP:0010639","MP:0010768","MP:0011085","MP:0011086","MP:0011089","MP:0011091","MP:0011092","MP:0011098","MP:0011106","MP:0011109","MP:0012087","MP:0012135","MP:0012136","MP:0012156","MP:0012157","MP:0012165","MP:0012176","MP:0012434","MP:0012700"],
      "pheno_EMMA":"Mice develop life-shortening intestinal polyposis.",
      "_version_":1837342283558551552
    },{
      "id_str":"5945",
      "name_str":"B6.129-Kras<tm1Bbd>/Cnbc",
      "models":["human/mouse","human/mouse","mouse","mouse","mouse","mouse"],
      "gene_symbol":"Kras",
      "do_id":["DOID:1324","DOID:4905","DOID:9119","DOID:4928","DOID:0050458","DOID:10283"],
      "do_term":["lung cancer","pancreatic carcinoma","acute myeloid leukemia","intrahepatic cholangiocarcinoma","juvenile myelomonocytic leukemia","prostate cancer"],
      "mp_term":["abnormal ear position","increased leukocyte cell number","increased neutrophil cell number","abnormal systemic arterial blood pressure","hypertension","extramedullary hematopoiesis","abnormal heart morphology","enlarged heart","heart hyperplasia","thin ventricular wall","cellular necrosis","increased cell proliferation","abnormal cranium morphology","increased cranium width","flattened snout","liver hypoplasia","small liver","pale liver","enlarged spleen","abnormal brain development","decreased body length","decreased body size","ocular hypertelorism","anemia","decreased embryo size","pericardial edema","increased papilloma incidence","increased tumor incidence","increased T cell derived lymphoma incidence","increased lung adenocarcinoma incidence","increased sarcoma incidence","increased carcinoma incidence","increased lung adenoma incidence","increased skin papilloma incidence","premature death","abnormal definitive hematopoiesis","abnormal kidney morphology","no abnormal phenotype detected","small heart","abnormal bronchus morphology","abnormal hematopoietic system morphology/development","increased basophil cell number","thin myocardium","dilated cardiomyopathy","no phenotypic analysis","cardiac fibrosis","thrombocytopenia","increased neuron apoptosis","increased cardiac output","abnormal fetal cardiomyocyte proliferation","increased hemangiosarcoma incidence","pallor","abnormal facial morphology","embryonic growth retardation","fetal growth retardation","increased squamous cell carcinoma incidence","abnormal myocardial fiber physiology","abnormal embryonic neuroepithelium morphology","enlarged myocardial fiber","increased hematopoietic stem cell number","abnormal large intestine crypts of Lieberkuhn morphology","increased eosinophil cell number","decreased cardiac muscle contractility","liver/biliary system phenotype","hematopoietic system phenotype","increased cardiac muscle contractility","increased apoptosis","increased systemic arterial diastolic blood pressure","increased systemic arterial systolic blood pressure","increased myocardial fiber number","abnormal common myeloid progenitor cell morphology","increased lung tumor incidence","decreased CD8-positive","alpha-beta T cell number","abnormal common lymphocyte progenitor cell morphology","slow postnatal weight gain","abnormal bone marrow cell physiology","spleen vascular congestion","decreased lung tumor incidence","increased mesothelioma incidence","increased fibrosarcoma incidence","thick aortic valve","perinatal lethality","complete penetrance","perinatal lethality","incomplete penetrance","prenatal lethality","complete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","increased cranium height","decreased cranium length","increased lymphoma incidence","triangular face","increased embryonic neuroepithelium apoptosis","increased myeloid cell number","increased granulocyte monocyte progenitor cell number"],
      "mp_id":["MP:0000023","MP:0000218","MP:0000219","MP:0000230","MP:0000231","MP:0000240","MP:0000266","MP:0000274","MP:0000275","MP:0000280","MP:0000316","MP:0000351","MP:0000438","MP:0000441","MP:0000447","MP:0000600","MP:0000601","MP:0000603","MP:0000691","MP:0000913","MP:0001258","MP:0001265","MP:0001300","MP:0001577","MP:0001698","MP:0001787","MP:0002014","MP:0002020","MP:0002024","MP:0002027","MP:0002032","MP:0002038","MP:0002048","MP:0002051","MP:0002083","MP:0002123","MP:0002135","MP:0002169","MP:0002188","MP:0002264","MP:0002396","MP:0002606","MP:0002652","MP:0002795","MP:0003012","MP:0003141","MP:0003179","MP:0003203","MP:0003394","MP:0003567","MP:0003667","MP:0003717","MP:0003743","MP:0003984","MP:0004201","MP:0004207","MP:0004215","MP:0004261","MP:0004564","MP:0004809","MP:0004842","MP:0005011","MP:0005140","MP:0005370","MP:0005397","MP:0005599","MP:0006042","MP:0006143","MP:0006144","MP:0006321","MP:0006410","MP:0008014","MP:0008079","MP:0008249","MP:0008489","MP:0009278","MP:0010020","MP:0010267","MP:0010309","MP:0010363","MP:0010594","MP:0011089","MP:0011090","MP:0011091","MP:0011092","MP:0011098","MP:0011861","MP:0011862","MP:0012431","MP:0012546","MP:0012701","MP:0013663","MP:0013696"],
      "pheno_EMMA":"In heterozygosis, before cre-mediated recombination, there is no obvious phenotype but the mutation is embryonic lethal in homozygosis due to the lack of Kras expression. After germ line cre-mediated recombination the excised allele is embryonic lethal in heterozygosis. If the level of recombination is low in the embryo, even if it is ubiquitous (small percentage of cells recombined) the mice that are born develop spontaneous lung tumors.",
      "_version_":1837342279735443456
    }]
  }
}