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proliferation","decreased splenocyte apoptosis","increased thymocyte apoptosis","decreased thymocyte apoptosis","abnormal abdominal lymph node morphology","decreased sensitivity to induced morbidity/mortality","increased sensitivity to xenobiotic induced morbidity/mortality","increased tumor latency","abnormal neuron differentiation","increased reproductive system tumor incidence","increased urinary system tumor incidence","increased skin tumor incidence","increased hamartoma incidence","abnormal tumor latency","decreased tumor latency","increased lipoma incidence","increased hibernoma incidence","increased teratocarcinoma incidence","increased fibrosarcoma incidence","increased spindle cell carcinoma incidence","increased adenoma incidence","abnormal hematopoietic stem cell physiology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","embryonic lethality during organogenesis","complete penetrance","preweaning lethality","complete penetrance","prenatal lethality","incomplete penetrance","embryonic lethality during organogenesis","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","preweaning lethality","incomplete penetrance","increased tail pigmentation","increased fibroblast proliferation","decreased hematopoietic stem cell proliferation","nail dystrophy","increased lymphoma incidence","abnormal tail tip morphology","decreased fibroblast apoptosis","adipose tissue inflammation"], "mp_id":["MP:0000063","MP:0000067","MP:0000160","MP:0000162","MP:0000208","MP:0000221","MP:0000222","MP:0000240","MP:0000274","MP:0000313","MP:0000333","MP:0000343","MP:0000350","MP:0000351","MP:0000352","MP:0000367","MP:0000416","MP:0000423","MP:0000512","MP:0000558","MP:0000569","MP:0000575","MP:0000585","MP:0000599","MP:0000600","MP:0000628","MP:0000689","MP:0000691","MP:0000692","MP:0000693","MP:0000694","MP:0000696","MP:0000703","MP:0000706","MP:0000762","MP:0000774","MP:0000851","MP:0000857","MP:0000865","MP:0000875","MP:0000914","MP:0001116","MP:0001147","MP:0001156","MP:0001204","MP:0001212","MP:0001244","MP:0001262","MP:0001263","MP:0001265","MP:0001272","MP:0001325","MP:0001330","MP:0001333","MP:0001393","MP:0001544","MP:0001545","MP:0001577","MP:0001625","MP:0001648","MP:0001658","MP:0001732","MP:0001846","MP:0001860","MP:0001861","MP:0001864","MP:0001883","MP:0001914","MP:0001940","MP:0002006","MP:0002019","MP:0002020","MP:0002023","MP:0002024","MP:0002026","MP:0002027","MP:0002032","MP:0002035","MP:0002036","MP:0002038","MP:0002048","MP:0002051","MP:0002052","MP:0002083","MP:0002109","MP:0002123","MP:0002169","MP:0002269","MP:0002357","MP:0002362","MP:0002404","MP:0002413","MP:0002619","MP:0002627","MP:0002628","MP:0002700","MP:0002792","MP:0002833","MP:0002864","MP:0002875","MP:0002908","MP:0002947","MP:0003010","MP:0003012","MP:0003046","MP:0003077","MP:0003155","MP:0003179","MP:0003204","MP:0003207","MP:0003269","MP:0003299","MP:0003331","MP:0003402","MP:0003446","MP:0003447","MP:0003448","MP:0003667","MP:0003674","MP:0003717","MP:0003751","MP:0003763","MP:0003786","MP:0003789","MP:0003918","MP:0003927","MP:0003992","MP:0004023","MP:0004024","MP:0004025","MP:0004029","MP:0004045","MP:0004097","MP:0004174","MP:0004207","MP:0004227","MP:0004228","MP:0004478","MP:0004499","MP:0004500","MP:0004502","MP:0004701","MP:0004809","MP:0004810","MP:0004819","MP:0004852","MP:0004953","MP:0004981","MP:0005095","MP:0005141","MP:0005152","MP:0005195","MP:0005202","MP:0005238","MP:0005378","MP:0005384","MP:0005387","MP:0005389","MP:0005409","MP:0005601","MP:0005621","MP:0006043","MP:0006050","MP:0006099","MP:0006219","MP:0006221","MP:0006283","MP:0006301","MP:0006410","MP:0006414","MP:0008000","MP:0008009","MP:0008011","MP:0008019","MP:0008057","MP:0008186","MP:0008280","MP:0008410","MP:0008411","MP:0008477","MP:0008553","MP:0008577","MP:0008596","MP:0008623","MP:0008626","MP:0008770","MP:0008813","MP:0008844","MP:0008866","MP:0008872","MP:0008884","MP:0008885","MP:0008943","MP:0008944","MP:0008973","MP:0009153","MP:0009258","MP:0009277","MP:0009308","MP:0009317","MP:0009318","MP:0009321","MP:0009336","MP:0009341","MP:0009541","MP:0009542","MP:0009625","MP:0009764","MP:0009766","MP:0009828","MP:0009937","MP:0010287","MP:0010289","MP:0010300","MP:0010306","MP:0010307","MP:0010308","MP:0010343","MP:0010344","MP:0010349","MP:0010363","MP:0010367","MP:0010383","MP:0010763","MP:0010768","MP:0011085","MP:0011086","MP:0011098","MP:0011100","MP:0011101","MP:0011108","MP:0011109","MP:0011110","MP:0011276","MP:0011703","MP:0011903","MP:0012400","MP:0012431","MP:0013177","MP:0013502","MP:0020386"], "pheno_EMMA":"Mice that are homozygous for the targeted Trp53 mutation (i.e. Hupki) are healthy, fertile and do not display any gross abnormalities. The expression and functional activity of the chimeric Trp53 gene in homozygous Hupki mice is normal. Homozygous Hupki mice that are also homozygous for the targeted Xpa knockout mutation (i.e. Xpa-null) are viable and fertile and do not undergo spontaneous tumour development. Xpa is required for nucleotide excision repair (NER), therefore Xpa-Null mice and cells are completely deficient in NER. Hupki:Xpa-Null mice and embryo fibroblasts are highly sensitive to carcinogens that generate DNA damage normally repaired by NER (e.g. bulky DNA adducts) compared with Hupki:Xpa-wild-type controls (unpublished data).", "_version_":1837342278889242624 },{ "id_str":"9622", "name_str":"C57BL/6N-Sipa1/H", "models":["mouse"], "gene_symbol":"Sipa1", "do_id":["DOID:8552"], "do_term":["chronic myeloid leukemia"], "mp_term":["increased leukocyte cell number","extramedullary hematopoiesis","increased bone marrow cell number","increased granulocyte number","enlarged spleen","spleen hyperplasia","anemia","abnormal definitive hematopoiesis","abnormal bone marrow cell morphology/development","decreased erythrocyte cell number","increased hematopoietic stem cell number","pancytopenia","increased chronic myelocytic leukemia incidence"], "mp_id":["MP:0000218","MP:0000240","MP:0000321","MP:0000322","MP:0000691","MP:0000693","MP:0001577","MP:0002123","MP:0002398","MP:0002875","MP:0004809","MP:0005152","MP:0005481"], "pheno_EMMA":"Potential phenotyping data in the IMPC portal", "_version_":1837342278920699904 },{ "id_str":"13081", "name_str":"B6;CBA-Nf1/Flmg", "models":["mouse"], "gene_symbol":"Nf1", "do_id":["DOID:0050458"], "do_term":["juvenile myelomonocytic leukemia"], "mp_term":["vasculature congestion","abnormal heart development","enlarged heart","abnormal heart shape","double outlet right ventricle","abnormal heart valve morphology","distended pericardium","abnormal atrioventricular cushion morphology","megacephaly","delayed kidney development","increased foot pad pigmentation","delayed hepatic development","liver hypoplasia","pale liver","delayed muscle development","abnormal tongue morphology","exencephaly","paravertebral ganglia hyperplasia","prevertebral ganglia hyperplasia","enlarged chest","microphthalmia","impaired coordination","abnormal spatial learning","focal hepatic necrosis","edema","abnormal lymphatic vessel morphology","hemorrhage","neoplasm","increased tumor incidence","increased leukemia incidence","increased lung adenocarcinoma incidence","increased neurofibrosarcoma incidence","increased adrenal gland tumor incidence","increased pheochromocytoma incidence","abnormal muscle morphology","no abnormal phenotype detected","disorganized myocardium","hydrops fetalis","abnormal mast cell physiology","persistent truncus arteriosis","abnormal vein morphology","heart hypoplasia","abnormal discrimination learning","decreased circulating alanine transaminase level","nervous system phenotype","pallor","increased atrioventricular cushion size","liver hemorrhage","decreased renal glomerulus number","decreased eye pigmentation","pericardial effusion","abnormal myocardium layer morphology","decreased lactate dehydrogenase level","abnormal enzyme/coenzyme activity","decreased circulating aspartate transaminase level","abnormal fetal atrioventricular canal morphology","increased mast cell degranulation","skeletal muscle hypoplasia","abnormal neural crest cell morphology","increased hepatoma incidence","increased neurofibroma incidence","pleural effusion","increased fibrosarcoma incidence","ventricular septal defect","abnormal mitral valve cusp morphology","postnatal lethality","complete penetrance","prenatal lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","lethality throughout fetal growth and development","complete penetrance","increased tail pigmentation","increased ear pigmentation","abnormal metanephros morphology","increased lymphoma incidence"], "mp_id":["MP:0000255","MP:0000267","MP:0000274","MP:0000277","MP:0000284","MP:0000285","MP:0000292","MP:0000297","MP:0000434","MP:0000528","MP:0000575","MP:0000597","MP:0000600","MP:0000603","MP:0000736","MP:0000762","MP:0000914","MP:0001009","MP:0001010","MP:0001267","MP:0001297","MP:0001405","MP:0001463","MP:0001656","MP:0001785","MP:0001879","MP:0001914","MP:0002006","MP:0002020","MP:0002026","MP:0002027","MP:0002030","MP:0002031","MP:0002050","MP:0002108","MP:0002169","MP:0002190","MP:0002192","MP:0002423","MP:0002633","MP:0002725","MP:0002740","MP:0002802","MP:0002942","MP:0003631","MP:0003717","MP:0003808","MP:0003888","MP:0004505","MP:0005172","MP:0005312","MP:0005329","MP:0005571","MP:0005584","MP:0005632","MP:0006107","MP:0008764","MP:0009460","MP:0009845","MP:0010264","MP:0010314","MP:0010334","MP:0010363","MP:0010402","MP:0010614","MP:0011085","MP:0011091","MP:0011098","MP:0011099","MP:0011276","MP:0011278","MP:0011364","MP:0012431"], "pheno_EMMA":"Embryonic lethal", "_version_":1837342278953205760 },{ "id_str":"5137", "name_str":"C57BL/6J-Fgf9/Ieg", "models":["mouse","mouse"], "gene_symbol":"Fgf9", "do_id":["DOID:1324","DOID:4769"], "do_term":["lung cancer","pleuropulmonary blastoma"], "mp_term":["abnormal tympanic ring morphology","abnormal cochlea morphology","delayed bone ossification","short premaxilla","cleft palate","abnormal tooth development","abnormal sternum morphology","abnormal cartilage development","abnormal heart development","abnormal cecum morphology","abnormal small intestine morphology","short limbs","abnormal radius morphology","synostosis","kinked tail","short tail","abnormal testis morphology","abnormal lung morphology","pulmonary hypoplasia","ocular hypertelorism","cataract","small lens","abnormal suckling behavior","cyanosis","abnormal digestive system physiology","postnatal growth retardation","testis hypoplasia","respiratory failure","respiratory distress","hypopnea","postnatal lethality","abnormal vision","no abnormal phenotype detected","abnormal primary sex determination","heart hypoplasia","exophthalmos","dilated heart left ventricle","dilated heart right ventricle","short tibia","short fibula","abnormal joint morphology","primary sex reversal","ovotestis","curly tail","short femur","dilated heart atrium","fused joints","calcified joint","abnormal voluntary movement","abnormal fetal cardiomyocyte proliferation","small lung","pallor","abnormal long bone morphology","abnormal Sertoli cell development","abnormal intervertebral disk morphology","short sternum","short humerus","short radius","short ulna","short nasal bone","abnormal vertebral arch morphology","vertebral fusion","fusion of vertebral arches","caudal vertebral fusion","wide ribs","abnormal small intestine crypts of Lieberkuhn morphology","epididymis hypoplasia","hypoxia","abnormal temporal bone morphology","abnormal humerus morphology","abnormal incisor morphology","renal/urinary system phenotype","endocrine/exocrine gland phenotype","respiratory system phenotype","reproductive system phenotype","skeleton phenotype","vision/eye phenotype","abnormal lens development","decreased lung weight","abnormal limb development","abnormal testis cord formation","disorganized testis cords","decreased number of peritubular myoid cells","dilated heart ventricle","increased diameter of femur","increased diameter of fibula","increased diameter of humerus","increased diameter of radius","increased diameter of tibia","increased diameter of ulna","enlarged heart atrium","decreased fetal weight","enlarged eye anterior chamber","cleft secondary palate","abnormal coccyx morphology","mortality/aging","abnormal branching involved in lung morphogenesis","lethality at weaning","incomplete penetrance","postnatal lethality","incomplete penetrance","neonatal lethality","complete penetrance","perinatal lethality","complete penetrance","abnormal lung-associated mesenchyme development","abnormal mesenchymal cell proliferation involved in lung development","increased chondrocyte number","midface hypoplasia","abnormal Leydig cell differentiation","increased bone ossification","high forehead","premature coronal suture closure","premature sagittal suture closure","enlarged Meckel's cartilage","misaligned incisors","abnormal knee joint morphology"], "mp_id":["MP:0000030","MP:0000031","MP:0000060","MP:0000091","MP:0000111","MP:0000116","MP:0000157","MP:0000164","MP:0000267","MP:0000494","MP:0000496","MP:0000547","MP:0000552","MP:0000566","MP:0000585","MP:0000592","MP:0001146","MP:0001175","MP:0001178","MP:0001300","MP:0001304","MP:0001306","MP:0001436","MP:0001575","MP:0001663","MP:0001732","MP:0001940","MP:0001953","MP:0001954","MP:0001956","MP:0002082","MP:0002090","MP:0002169","MP:0002211","MP:0002740","MP:0002750","MP:0002753","MP:0002754","MP:0002764","MP:0002765","MP:0002932","MP:0002995","MP:0002996","MP:0003051","MP:0003109","MP:0003140","MP:0003189","MP:0003200","MP:0003491","MP:0003567","MP:0003641","MP:0003717","MP:0003723","MP:0004109","MP:0004173","MP:0004321","MP:0004351","MP:0004355","MP:0004359","MP:0004471","MP:0004599","MP:0004609","MP:0004613","MP:0004619","MP:0004676","MP:0004841","MP:0004932","MP:0005039","MP:0005272","MP:0005296","MP:0005358","MP:0005367","MP:0005379","MP:0005388","MP:0005389","MP:0005390","MP:0005391","MP:0005545","MP:0005631","MP:0006279","MP:0006418","MP:0006419","MP:0006421","MP:0008022","MP:0008158","MP:0008159","MP:0008160","MP:0008161","MP:0008162","MP:0008163","MP:0008725","MP:0009431","MP:0009829","MP:0009890","MP:0010114","MP:0010768","MP:0011024","MP:0011084","MP:0011086","MP:0011087","MP:0011089","MP:0011142","MP:0011146","MP:0011692","MP:0012085","MP:0013602","MP:0020039","MP:0030032","MP:0030350","MP:0030354","MP:0030372","MP:0030541","MP:0030837"], "pheno_EMMA":"Aca12 is characterized by microphthalmia and microphakia.", "_version_":1837342278985711616 },{ "id_str":"13246", "name_str":"C57BL/6-Pik3ca/H", "models":["human/mouse","human/mouse"], "gene_symbol":"Pik3ca", "do_id":["DOID:1612","DOID:2394"], "do_term":["breast cancer","ovarian cancer"], "mp_term":["vasculature congestion","abnormal vascular development","abnormal angiogenesis","decreased cell proliferation","decreased body length","decreased body weight","polyphagia","internal hemorrhage","abnormal somite development","decreased embryo size","pale yolk sac","embryonic growth arrest","postnatal growth retardation","abnormal lymphatic vessel morphology","hemorrhage","neoplasm","increased circulating insulin level","abnormal retinal vasculature morphology","no phenotypic analysis","abnormal vitelline vasculature morphology","increased pancreatic beta cell number","decreased lean body mass","abnormal endocardium morphology","embryonic growth retardation","abnormal vitelline vascular remodeling","fetal growth retardation","decreased incidence of tumors by chemical induction","abnormal anterior cardinal vein morphology","abnormal dorsal aorta morphology","decreased skeletal muscle mass","abnormal brain vasculature morphology","impaired glucose tolerance","insulin resistance","abnormal cell physiology","increased circulating leptin level","increased fat cell size","abnormal lymphangiogenesis","mortality/aging","postnatal lethality","incomplete penetrance","neonatal lethality","incomplete penetrance","embryonic lethality","complete penetrance","embryonic lethality during organogenesis","complete penetrance","chylous ascites","abnormal intersomitic vessel morphology","abnormal perineural vascular plexus morphology"], "mp_id":["MP:0000255","MP:0000259","MP:0000260","MP:0000352","MP:0001258","MP:0001262","MP:0001433","MP:0001634","MP:0001688","MP:0001698","MP:0001722","MP:0001730","MP:0001732","MP:0001879","MP:0001914","MP:0002006","MP:0002079","MP:0002792","MP:0003012","MP:0003229","MP:0003645","MP:0003961","MP:0003974","MP:0003984","MP:0004076","MP:0004201","MP:0004502","MP:0004784","MP:0004787","MP:0004819","MP:0004950","MP:0005293","MP:0005331","MP:0005621","MP:0005669","MP:0006094","MP:0008778","MP:0010768","MP:0011086","MP:0011088","MP:0011092","MP:0011098","MP:0012080","MP:0012253","MP:0012732"], "pheno_EMMA":"Mice are phenotypically normal.", "_version_":1837342279017168896 },{ "id_str":"3996", "name_str":"C57BL/6NTac-Asxl1/Cnrm", "models":["mouse","mouse","mouse"], "gene_symbol":"Asxl1", "do_id":["DOID:9119","DOID:0050908","DOID:2226"], "do_term":["acute myeloid leukemia","myelodysplastic syndrome","myeloproliferative neoplasm"], "mp_term":["cleft palate","increased leukocyte cell number","increased monocyte cell number","decreased leukocyte cell number","decreased neutrophil cell number","extramedullary hematopoiesis","increased bone marrow cell number","decreased bone marrow cell number","increased cell proliferation","abnormal craniofacial morphology","mandible hypoplasia","abnormal liver morphology","enlarged liver","abnormal spleen morphology","enlarged spleen","small spleen","spleen hyperplasia","abnormal thymus morphology","abnormal immune system cell morphology","decreased body weight","decreased body size","anophthalmia","microphthalmia","abnormal cornea morphology","corneal opacity","anemia","abnormal myelopoiesis","impaired hematopoiesis","increased malignant tumor incidence","increased leukemia incidence","increased sarcoma incidence","premature death","abnormal spleen white pulp morphology","abnormal bone marrow cell morphology/development","abnormal lymphopoiesis","abnormal megakaryocyte morphology","abnormal blood cell morphology/development","abnormal neutrophil physiology","opacity of vitreous body","abnormal immune system organ morphology","decreased hemoglobin content","vertebral transformation","abnormal hyoid bone morphology","thrombocytopenia","spleen atrophy","vertebral fusion","decreased lumbar vertebrae number","increased hematopoietic stem cell number","decreased hematopoietic stem cell number","decreased spleen weight","decreased lymphocyte cell number","decreased B cell number","decreased T cell number","abnormal neutrophil morphology","increased double-negative T cell number","polychromatophilia","abnormal skeleton morphology","decreased circulating glucose level","decreased mean corpuscular hemoglobin","increased apoptosis","abnormal common myeloid progenitor cell morphology","decreased CD4-positive","alpha beta T cell number","increased single-positive T cell number","decreased pre-B cell number","abnormal leukocyte morphology","decreased spleen red pulp amount","increased blood uric acid level","decreased erythroid progenitor cell number","eye opacity","increased sacral vertebrae number","increased number of Howell-Jolly bodies","myeloid hyperplasia","abnormal hematopoietic stem cell physiology","postnatal lethality","incomplete penetrance","neonatal lethality","incomplete penetrance","lethality throughout fetal growth and development","complete penetrance","lethality throughout fetal growth and development","incomplete penetrance","lethality","complete penetrance"], "mp_id":["MP:0000111","MP:0000218","MP:0000220","MP:0000221","MP:0000222","MP:0000240","MP:0000321","MP:0000333","MP:0000351","MP:0000428","MP:0000460","MP:0000598","MP:0000599","MP:0000689","MP:0000691","MP:0000692","MP:0000693","MP:0000703","MP:0000716","MP:0001262","MP:0001265","MP:0001293","MP:0001297","MP:0001312","MP:0001314","MP:0001577","MP:0001601","MP:0001606","MP:0002018","MP:0002026","MP:0002032","MP:0002083","MP:0002357","MP:0002398","MP:0002401","MP:0002417","MP:0002429","MP:0002463","MP:0002700","MP:0002722","MP:0002874","MP:0003036","MP:0003056","MP:0003179","MP:0003643","MP:0004609","MP:0004647","MP:0004809","MP:0004810","MP:0004953","MP:0005016","MP:0005017","MP:0005018","MP:0005065","MP:0005090","MP:0005097","MP:0005508","MP:0005560","MP:0005562","MP:0006042","MP:0006410","MP:0008075","MP:0008082","MP:0008209","MP:0008246","MP:0008477","MP:0008821","MP:0008973","MP:0009859","MP:0010101","MP:0010178","MP:0010373","MP:0010763","MP:0011086","MP:0011088","MP:0011099","MP:0011109","MP:0011400"], "pheno_EMMA":"Potential phenotyping data in the IMPC portal", "_version_":1837342279051771904 },{ "id_str":"11742", "name_str":"B6.129S6(Cg)-Trp53/H", "models":["human/mouse","mouse","mouse","mouse","mouse"], "gene_symbol":"Trp53", "do_id":["DOID:1612","DOID:0050745","DOID:1380","DOID:3068","DOID:3347"], "do_term":["breast cancer","diffuse large B-cell lymphoma","endometrial cancer","glioblastoma multiforme","osteosarcoma"], "mp_term":["decreased bone mineral density","osteopetrosis","kyphosis","lordosis","decreased hematocrit","decreased leukocyte cell number","decreased neutrophil cell number","extramedullary hematopoiesis","enlarged heart","abnormal cell death","decreased bone marrow cell number","altered response to myocardial infarction","abnormal cell proliferation","increased cell proliferation","decreased cell proliferation","abnormal coat/ hair morphology","sparse hair","delayed hair regrowth","intestinal ulcer","abnormal tibia morphology","abnormal digit pigmentation","increased foot pad pigmentation","kinked tail","enlarged liver","liver hypoplasia","abnormal mammary gland development","abnormal spleen morphology","enlarged spleen","small spleen","spleen hyperplasia","spleen hypoplasia","abnormal Peyer's patch morphology","abnormal thymus morphology","small thymus","abnormal tongue morphology","decreased brain size","cerebellum hypoplasia","abnormal cerebellar foliation","absent cerebellum vermis","abnormal cerebellar Purkinje cell layer","exencephaly","small gonad","small testis","abnormal spermatogenesis","decreased sensitivity to skin irradiation","skin lesions","thin dermal layer","decreased body weight","weight loss","decreased body size","increased metastatic potential","abnormal retina morphology","abnormal optic nerve morphology","absent optic nerve","ataxia","abnormal cardiovascular system physiology","abnormal hematopoietic system physiology","anemia","cardiac hypertrophy","abnormal apoptosis","increased mortality induced by gamma-irradiation","postnatal growth retardation","increased inflammatory response","liver inflammation","lung inflammation","vasculitis","increased mammary adenocarcinoma incidence","hemorrhage","testis hypoplasia","neoplasm","abnormal tumor incidence","increased tumor incidence","increased B cell derived lymphoma incidence","increased T cell derived lymphoma incidence","increased leukemia incidence","increased lung adenocarcinoma incidence","increased sarcoma incidence","increased leiomyosarcoma incidence","increased rhabdomyosarcoma incidence","increased carcinoma incidence","increased lung adenoma incidence","increased skin papilloma incidence","decreased tumor incidence","premature death","abnormal limb morphology","abnormal definitive hematopoiesis","no abnormal phenotype detected","muscular atrophy","abnormal spleen white pulp morphology","abnormal spleen marginal zone morphology","increased intestinal adenoma incidence","abnormal megakaryocyte progenitor cell morphology","abnormal lymphocyte morphology","increased teratoma incidence","hepatic steatosis","opacity of vitreous body","abnormal retinal vasculature morphology","increased heart weight","abnormal ocular fundus morphology","decreased erythrocyte cell number","delayed wound healing","increased hemangioma incidence","decreased mortality induced by ionizing radiation","no phenotypic analysis","liver cirrhosis","abnormal cell cycle","abnormal telomere length","thrombocytopenia","decreased neuron apoptosis","decreased cellular sensitivity to gamma-irradiation","colon polyps","gastric polyps","increased hepatocellular carcinoma incidence","decreased liver weight","renal hypoplasia","decreased tumor growth/size","abnormal tumor morphology","increased hemangiosarcoma incidence","oxidative stress","pallor","oral leukoplakia","abnormal thymus physiology","premature aging","increased osteosarcoma incidence","decreased kidney weight","enhanced cellular glucose import","increased mortality induced by ionizing radiation","abnormal chromosome number","aneuploidy","polyploidy","spontaneous chromosome breakage","abnormal cell cycle checkpoint function","abnormal cerebellar cortex morphology","abnormal spine curvature","increased squamous cell carcinoma incidence","increased cellular sensitivity to ionizing radiation","decreased cellular sensitivity to ionizing radiation","increased testicular teratoma incidence","increased incidence of tumors by chemical induction","increased incidence of tumors by ionizing radiation induction","decreased incidence of tumors by chemical induction","decreased circulating insulin-like growth factor I level","increased hematopoietic stem cell number","decreased hematopoietic stem cell number","decreased skeletal muscle mass","decreased testis weight","decreased spleen weight","decreased neuronal precursor cell number","decreased T cell proliferation","liver hyperplasia","pancytopenia","abnormal posterior eye segment morphology","lethargy","increased brain size","growth/size/body region phenotype","cellular phenotype","immune system phenotype","reproductive system phenotype","darkened coat color","increased angiogenesis","abnormal cell physiology","decreased apoptosis","pulmonary fibrosis","thin cerebellar granule layer","optic nerve degeneration","optic nerve hypoplasia","increased medulloblastoma incidence","abnormal mesenchyme morphology","abnormal common myeloid progenitor cell morphology","decreased T cell apoptosis","increased ovary tumor incidence","delayed cellular replicative senescence","intestine polyps","increased liver tumor incidence","abnormal DNA replication","increased pro-B cell number","abnormal male germ cell apoptosis","increased cellular sensitivity to ultraviolet irradiation","decreased cellular sensitivity to ultraviolet irradiation","decreased spleen red pulp amount","increased circulating tumor necrosis factor level","increased circulating interferon-gamma level","increased circulating interleukin-6 level","increased circulating interleukin-3 level","increased circulating interleukin-5 level","decreased survivor rate","decreased common myeloid progenitor cell number","decreased subcutaneous adipose tissue amount","chromosomal instability","abnormal physiological response to xenobiotic","abnormal enterocyte apoptosis","increased enterocyte apoptosis","increased sensitivity to induced cell death","decreased sensitivity to induced cell death","decreased erythroid progenitor cell number","increased pancreas tumor incidence","abnormal thymocyte apoptosis","increased brain tumor incidence","increased adenocarcinoma incidence","increased follicular lymphoma incidence","increased splenic marginal zone lymphoma incidence","increased histiocytic sarcoma incidence","increased splenocyte proliferation","decreased splenocyte apoptosis","increased thymocyte apoptosis","decreased thymocyte apoptosis","abnormal abdominal lymph node morphology","decreased sensitivity to induced morbidity/mortality","increased sensitivity to xenobiotic induced morbidity/mortality","increased tumor latency","abnormal neuron differentiation","increased reproductive system tumor incidence","increased urinary system tumor incidence","increased skin tumor incidence","increased hamartoma incidence","abnormal tumor latency","decreased tumor latency","increased lipoma incidence","increased hibernoma incidence","increased teratocarcinoma incidence","increased fibrosarcoma incidence","increased spindle cell carcinoma incidence","increased adenoma incidence","abnormal hematopoietic stem cell physiology","mortality/aging","postnatal lethality","complete penetrance","postnatal lethality","incomplete penetrance","embryonic lethality during organogenesis","complete penetrance","preweaning lethality","complete penetrance","prenatal lethality","incomplete penetrance","embryonic lethality during organogenesis","incomplete penetrance","lethality throughout fetal growth and development","incomplete penetrance","preweaning lethality","incomplete penetrance","increased tail pigmentation","increased fibroblast proliferation","decreased hematopoietic stem cell proliferation","nail dystrophy","increased lymphoma incidence","abnormal tail tip morphology","decreased fibroblast apoptosis","adipose tissue inflammation"], 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"pheno_EMMA":"Untreated homozygous show no phenotype compared with wild-type. Homozygous mice exposed to DNA damage from X-rays or the N-methyl-N-nitrosourea (MNU) carcinogen are more susceptible to tumour formation than wild-type controls.", "_version_":1837342279088472064 }] } }