Systemic Phenotyping by The Centre for Phenogenomics

The Centre for Phenogenomics (TCP)

The Centre for Phenogenomics (TCP) is a state-of-the-art research facility located in Toronto, Canada. It is designed to foster collaboration among researchers across research domains and geography. TCP offers a range of services to support cutting-edge research in the fields of developmental, biomedical, and genomic research. TCP provides services from study design to execution, data analysis and resource sharing, catering to projects of different scales. TCP works with users locally, across Canada and worldwide. The staff at TCP are highly trained and certified in their respective fields, pooling their extensive experience to collaboratively deliver results to scientists from diverse disciplines. One of TCP’s primary goals is to contribute to medical research by advancing our understanding of the genetic basis of various diagnoses and treatments.

Service Description:

The Centre for Phenogenomics (TCP) produces and phenotypes mouse models for discovery and biomedical research. TCP’s team of experts and state-of-the-art infrastructure are available to help scientists advance their research programs by developing and phenotyping mouse models of development and disease. Leverage our expertise for all aspects of your mouse research so you can focus on data interpretation and research outcomes.

Our Services:

  • Animal Resources: Ethics review and approval, animal husbandry, and veterinary and technical services for in vivo research projects.

  • Model production: Design, produce and quality control genetically engineered mouse lines.

  • Clinical phenotyping: In vivo mouse phenotyping across a range of body systems for research, preclinical assessment and/or drug target validation and treatment effect.

  • Imaging: Multi-modal imaging technologies for three-dimensional analysis of mouse anatomical phenotypes and more.

  • Pathology: Tissue analyses using histology with routine and special stains, immunohistochemistry, and immunofluorescence, along with a full range of digital pathology and image analysis.

  • Archiving & distribution: Mouse line cryopreservation and reanimation as well as global acquisition and distribution of mouse lines.

Included in the Service:

TCP works with clients to develop project plans that best suit their needs. Costs are based on the project plan. We can provide cost estimates, statements of work, and/or letters of support for budgetary purposes and grant applications.

Additional Support

TCP collaborates with multiple research service providers to ensure our clients have access to cutting-edge technologies across domains for their research projects.

  • Infection studies with bacteria, viruses, parasites, and fungi in CL2 and CL3 as well as inflammatory models are supported by our collaborators at the McGill Infection and Inflammation Platform.
  • Proteomics and metabolomics studies, including several quantitative mouse tissue proteomics assays developed in collaboration with TCP, can be executed at the Proteomics Centre at the University of Victoria.
  • Sanger and next generation sequencing for quality control of animal models and transcriptomics are conducted at The Centre for Applied Genomics.
Relevant Publications

  1. Peterson K A, Khalouei S, Hanafi N, et al. Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity. Commun Biol. 2023; 6(1), 626. doi.org/10.1038/s42003-023-04974-0

  2. Arbabi A, Spencer Noakes L, Vousden D, et al. Multiple-mouse magnetic resonance imaging with cryogenic radiofrequency probes for evaluation of brain development. NeuroImage. 2022; 252, 119008. doi.org/10.1016/j.neuroimage.2022.119008

  3. Rahman A, DeYoung T, Cahill L S, et al. A mouse model of hypoplastic left heart syndrome demonstrating left heart hypoplasia and retrograde aortic arch flow. Dis Model Mech. 2021; 14(11). doi.org/10.1242/dmm.049077

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