Systemic Phenotyping by HMGU

Systemic Phenotyping

by GMC-HMGU

Systemic Phenotyping at the German Mouse Clinic:

The German Mouse Clinic (GMC) at Helmholtz Munich (HMGU) provides a cutting-edge research infrastructure for mouse phenogenomics studies. It offers large-scale, standardised, and comprehensive phenotypic analysis, as well as customised phenotyping of mouse mutants from various sources.
GMC also specialises in the advanced analysis of phenotyping data, applying sophisticated biostatistical methods and AI-driven algorithms. Additionally, it has extensive experience working with aged mice. Mouse mutants are analysed based on scientific collaboration, using a broad, standardised phenotypic check-up covering all clinically relevant organ systems. The GMC modules are designated to the areas of behaviour, bone and cartilage development, neurology, clinical chemistry, eye development, immunology, allergy, energy metabolism, lung function, vision and pain perception, molecular phenotyping, cardiovascular analyses, and pathology. By characterising mouse models, GMC aims to understand the molecular mechanisms of human diseases and to contribute to the development of novel therapies.

Also Included:

GMC provides systemic phenotyping of young and aged mouse cohorts comprising all clinically relevant organ systems, including the scientific analyses and interpretation of the data. In addition to standardised primary tests, it offers specialised test-pipelines that can be customised to meet user needs.

Additional Support:

GMC has a longstanding expertise in the development, cryopreservation and archiving of mutant mouse models. Related to the phenotyping projects envisioned and after feasibility check at GMC, the Cryo Unit can provide comprehensive genome engineering resources from design to model production and validation. GMC offers consulting for experimental study design and for breeding strategy.

How to apply for the INFRAFRONTIER Systemic Phenotyping resource?

Please click the button below to fill out our Request Form or Pbagnpg hf if you have any questions.

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Request Systemic Phenotyping Here

Get to know the provider:

Helmholtz Munich, the German Research Center for Environmental Health, is a member of the Helmholtz Association, dedicated exclusively to health-related scientific research. The German Mouse Clinic (GMC) and the Cryo Unit are part of the Institute of Experimental Genetics which has a longstanding history in functional genomics studies of mammalian genomes using the mouse as a model organism. Additionally, they are a partner in the International Mouse Phenotyping Consortium (IMPC) and INFRAFRONTIER ERIC. The GMC provides a phenotyping platform for mouse models that covers all disease relevant organs. The different phenotyping modules are headed by experts in the field. The phenotyping screening platform provides access to state-of-the-art methods and equipment as imaging technologies (e.g. Magnetic Resonance Tomography, Computer Tomography, Echocardiography), expert pathological examination and trained personnel to support high quality phenotyping. The Cryo Unit operates as the German EMMA node: it actively archives and distributes mouse strains that have been developed inhouse, as well as others submitted to EMMA by external research partners.

Mice are housed in individually ventilated caging (IVC) systems under specific pathogen-free conditions. The GMC applies a strict quality policy and is certified according to the Quality Management System Standard DIN EN ISO 9001:2015. Reproducibility and traceability of analytical data, documentation, transparency and continuity are the cornerstones of the GMC quality management system.

GMC building

Mouse diets

FLIR Camera

Relevant Publications

Xie K, Fuchs F, et al., Hrabě de Angelis M & Ehninger D. Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice. Nat Commun, 2022; 13(1):6830. DOI: 10.1038/s41467-022-34515-y
Spielmann N, et al., Gailus-Durner V & Hrabě de Angelis M. Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy. Nat Cardiovasc Res, 20222; 1, 157–173. DOI: 10.1038/s44161-022-00018-8
Vidali S, Gerlini R, et al, Gailus-Durner V & Hrabě de Angelis M. Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes. EMBO Mol Med, 2021; e14397. DOI: 10.15252/emmm.202114397