COVID-19 BSL3 Pipeline

• The EC Horizon Europe funded ISIDORe project (2022 – 2025) supports eligible customers with a free-of-charge COVID-19 BSL3 Pipeline Service implemented as a Trans-national Access activity supporting a total of 6 projects in this call.
• The access unit offered covers the (1) suitable delivery of preventive therapeutics or vaccines pre-infection or curative therapeutic candidates after infection, (2) infection of COVID-19 mouse models (females) with appropriate SARS-CoV-2 virus titers, (3) monitoring of mice for mortality, morbidity and clinical symptoms and (4) determination of viral titers in the lung and brain.
• Only one access unit per therapeutic candidate will be provided. Additional candidates will require separate independent applications.
• Proposals with customized study designs for the BSL3 pipeline (other than the standard pipeline offered) or requiring any customization of the standard pipeline will be assessed on their technical and financial feasibility by the service provider.
• Support will be provided by the CIPHE experts to analyse and interpret the data.
• Accepted proposals will start with the provision of the therapeutic candidate that is ready to be injected and end with the delivery of infection data reports to selected applicants.
• Further functional analysis and advanced readouts like organ histopathological analysis, multiplex assay profiling of cytokines and chemokines in lung and mouse serum etc. can be provided on a collaborative basis outside the scope of this TA call.
• A final infection profile report will be provided as a deliverable.
• Costs: The access to the ISIDORe COVID-19 BSL3 Pipeline Service is free-of-charge. However, the shipment of the therapeutic compound to CIPHE must be borne by the applicants.
• Eligibility: The ISIDORe Trans-national Access call is open and proposals can be submitted from non-commercial applicants around the world.
• Application: Service requests for the ISIDORe COVID-19 BSL3 Pipeline Service can be made via this application form. Applications for the Trans-national Access activity must include a short description of why the therapeutic candidate is a candidate for a COVID-19 vaccine/treatment and future research plans after the ISIDORe TA service.
• Selection procedure: Proposals from eligible customers for free-of-charge access to the ISIDORe COVID-19 BSL3 Pipeline Service will be subject to a review procedure. Contact VFVQBEr for more information about the procedure. All applications will be handled with strict confidentiality.

TA activities provide trans-national access to researchers or research teams to one or more infrastructures among those operated by INFRAFRONTIER partners. These access activities are implemented in a coordinated way such as to improve the overall services available to the research community. Access is made available to external users, either in person (‘hands-on’) or through the provision of remote scientific services, such as the provision of reference materials or samples or analysis of samples.

Proposals for this Trans-national Access call can be submitted from non-commercial applicants around the world. Only 20% of the access units will be allocated to users that are not EU-member states or EU-associated states.

This TA service is covered by the ISIDORe project (Horizon Europe). The conditions for free access are 1) the user must work in an institution of a EU-Member State or EU-Associated State, 20% of access units will be allocated to international users, and 2) the user must be selected by the INFRAFRONTIER Evaluation Committee. The access to the COVID-19 therapeutic pipeline service is free-of-charge. However, the shipment of the therapeutic compound to CIPHE must be borne by the applicants.

Submitted project proposals will be collected and passed on by the ISIDORe Project Office to members of the external Evaluation Committee. All members of the Evaluation Committee signed a confidentiality agreement.

Proposals from eligible customers for free-of-charge access to the ISIDORe COVID-19 BSL3 Pipeline Service will be subject to a review procedure. Contact VFVQBEr for more information about the procedure.