B6Brd;B6N-Tyrc-Brd Atm1Brd Stat1tm2a(EUCOMM)Wtsi/CipheOrl

Status

Available to order

EMMA IDEM:08708
Citation informationRRID:IMSR_EM:08708 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6Brd;B6N-Tyrc-Brd Atm1Brd Stat1tm2a(EUCOMM)Wtsi/CipheOrl
Alternative nameEPD0607_3_A10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolStat1tm2a(EUCOMM)Wtsi
Gene/Transgene symbolStat1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Centre d'ImmunoPhenomique - Ciphe
Provider affiliationCentre d
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0607_3_A10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NCrl males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome / Orphanet_391487
    • Susceptibility to viral and mycobacterial infections due to STAT1 deficiency / Orphanet_391311
    • Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency / Orphanet_319595
IMPC phenotypes (gene matching)
  • increased monocyte cell number / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased neutrophil cell number / IMPC
  • increased lymphocyte cell number / IMPC
  • abnormal gait / IMPC
  • impaired righting response / IMPC
  • decreased mean corpuscular volume / IMPC
  • enlarged lymph nodes / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased bone mineral content / IMPC
  • increased leukocyte cell number / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • increased large unstained cell number / IMPC
  • increased eosinophil cell number / IMPC
  • increased basophil cell number / IMPC
MGI phenotypes (gene matching)
  • abnormal intestine morphology / MGI
  • abnormal tibia morphology / MGI
  • decreased body size / MGI
  • abnormal cornea morphology / MGI
  • multifocal hepatic necrosis / MGI
  • abnormal T cell activation / MGI
  • decreased level of surface class I molecules / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to bacterial infection / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal leukocyte physiology / MGI
  • abnormal macrophage physiology / MGI
  • increased IgG level / MGI
  • increased myocardial infarction size / MGI
  • abnormal cell cycle / MGI
  • abnormal redox activity / MGI
  • increased cardiomyocyte apoptosis / MGI
  • abnormal nitric oxide homeostasis / MGI
  • increased compact bone thickness / MGI
  • decreased B-1 B cell number / MGI
  • increased osteoclast cell number / MGI
  • increased bone resorption / MGI
  • decreased B cell number / MGI
  • abnormal response to infection / MGI
  • abnormal MHC II cell surface expression on macrophages / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • immune system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal T-helper 2 physiology / MGI
  • increased bone mass / MGI
  • abnormal cell physiology / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • increased NK T cell number / MGI
  • decreased NK cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • decreased susceptibility to neuronal excitotoxicity / MGI
  • abnormal osteoblast differentiation / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased interferon-gamma secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • decreased circulating interferon-gamma level / MGI
  • increased circulating interleukin-12b level / MGI
  • decreased interleukin-1 beta secretion / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • decreased NK cell degranulation / MGI
  • decreased hepatocyte apoptosis / MGI
  • decreased sensitivity to induced cell death / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • tumor regression / MGI
  • abnormal NK cell physiology / MGI
  • increased effector memory CD8-positive, alpha-beta T cell number / MGI
  • increased trabecular bone volume / MGI
  • increased compact bone volume / MGI
  • increased macrophage nitric oxide production / MGI
  • lethality at weaning, complete penetrance / MGI
  • abnormal CD8-positive, naive alpha-beta T cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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