Helmholtz Munich

Services:

German EMMA node
Mouse model development
Systemic phenotyping
Specialised phenotyping

Address:
Ingolstaedter Landstrasse 1
85764 Neuherberg (Munich)
Germany

Web: www.helmholtz-munich.de/en
Web: www.mouseclinic.de

Contact person:
Prof. Dr. Dr. h.c. mult. Martin Hrabě de Angelis
Head of IEG, Scientific Director of INFRAFRONTIER

Email:
rzzn-zhavpu@vasensebagvre.rh

Helmholtz Center Munich – German Research Center for Environmental Health is a member of the Helmholtz Association, dedicated exclusively to health-related scientific research. Helmholtz Association is the largest research organisation in Germany.

The central objective of HMGU’s Institute of Experimental Genetics (IEG) is to explore the pathogenesis of human diseases, with a focus on diabetes research. The IEG is a global leader in the systemic study of mouse models for human diseases and in deciphering the genes involved.

As part of IEG, the German Mouse Clinic (GMC) is specialised on the whole-body phenotyping of mutant mouse models evaluating numerous physiological pathways within a variety of therapeutic areas. In standardised pipelines, GMC constantly contributes phenotyping data to the worldwide databases of IMPC. Additionally, it offers an open access platform of several phenotyping pipelines including the scientific interpretation of data to clinical research teams from universities, scientific institutions and industry partners.

Since 1997, IEG has established its expertise in the development, cryopreservation and archiving of mutant mouse models. Today it provides an archive of more than 800 mutant mouse lines (sperm and embryos). IEG’s Cryo Unit operates as the German EMMA node: it actively archives and distributes mouse strains that have been developed inhouse, as well as others submitted to EMMA by external research partners.

Matching News

Scientific Publication September 26, 2024

Synergy Between Mouse and Human Brain Research in the Digital Era

Our colleagues from HMGU contributed to a groundbreaking pilot study integrating digital brain tools and genetic data. This works opens new paths to understanding rare diseases and neurodevelopmental disorders, paving the way for innovative therapies and insights into brain function.

Event October 2, 2024

The INFRAPLUS Project Successfully Launched in Munich

The INFRAPLUS’s kick-off took place over two productive days in Munich. With lively discussions and concrete plans, we have set the stage for INFRAFRONTIER’s expansion in state-of-the-art in vivo models, innovative in vitro models, preclinical services, and data analysis. All set to get started!

Scientific Publication July 5, 2024

Use of the IMPC Resource to Inform Psychiatric Research

Partners from the German Mouse Clinic (Helmholtz Munich), in collaboration with INFRAFRONTIER and IMPC colleagues, reveal a convergence of schizophrenia risk genes with mouse prepulse inhibition genes. Using hierarchical clustering and weighted gene co-expression network analysis, the study highlights neuronal genes involved in synaptic function and neurotransmission.

Scientific Publication June 19, 2024

A Role for Circular RNA in Behaviour

A new study by our partners at the German Mouse Clinic (at Helmholtz Munich) and colleagues from IBioBA-CONICET demonstrates that circular RNAs, specifically circTulp4, play a significant role in neural processes. The research used a loss-of-function animal model, showing that circTulp4 affects neurotransmission and brain behaviour.

Scientific Publication May 28, 2024

Assessment of Quality of Life and Wellbeing in Mouse Preclinical Research – A Scoping Review

The latest collaboration of INFRAFRONTIER with the German Mouse Clinic is available on line. This publication shows how standardising quality of life and wellbeing assessment protocols in mouse research can improve the relevance of these studies to human clinical trials. Supported by the CORBEL project.