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New research identified an endogenous factor influencing amyloid pathology in Alzheimer’s disease using the APPPS1-21 mouse model. The study opens doors to novel polymorphism-based interventions.
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity.
Using genetically sterile Prm1 males is a recognised alternative to surgical vasectomy when generating pseudopregnant females for embryo transfer programmes.
A new multi-organ disease named FINCA (Fibrosis, Neurodegeneration and Cerebral Angiomatosis) that is fatal in early childhood has been identified in three pediatric patients in Finland. Children affected have previously undescribed formation of connective tissue in the lungs, neurodegeneration and increased vasculature formation in the brain.