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The latest collaboration of INFRAFRONTIER with the German Mouse Clinic is available on line. This publication shows how standardising quality of life and wellbeing assessment protocols in mouse research can improve the relevance of these studies to human clinical trials. Supported by the CORBEL project.
In a groundbreaking study published in Nature, an international team of researchers, including our partners from CCP, has discovered a crucial link between autoimmune disorders and defects in tooth enamel development. This study sheds light on the poorly understood conditions of Amelogenesis Imperfecta in patients with Autoimmune Polyglandular Syndrome Type-1 (APS-1) and Celiac Disease.
The EOSC-Life consortium publishes an article in the EMBO Journal, outlining effective measures to boost the utilization and sustainability of data resources. The study also presents twelve recommendations for handling research data in alignment with FAIR principles.
A study conducted by the German Mouse Clinic and collaborating research institutions reveals a previously unknown connection between the DHX9 gene and various rare neurodevelopmental disorders.
Biomedcode’s Tg197 human TNF transgenic mouse model of chronic destructive arthritis provides new insights on how combination treatment with Dasatinib and low-dose anti-TNF leads to synergistic senolytic effects on chondrocytes and effective treatment of arthritis.
A Biomedcode collaboration has developed a human-RANKL dependent breast cancer mouse model aiming to study disease mechanisms and establish preclinical platforms for the evaluation of human therapeutics targeting cancer.
A new publication of INFRAFRONTIER in Mammalian Genome is available on line now. Get an overview of the latest INFRAFRONTIER advancements, including services, resources, and technical developments.
New research identified an endogenous factor influencing amyloid pathology in Alzheimer’s disease using the APPPS1-21 mouse model. The study opens doors to novel polymorphism-based interventions.
A useful resource for institutions that receive laboratory animals from colleagues or third parties to ensure that a tried and tested system of quality control is in place.
Mouse models are relevant to study the functionality of genes involved in human diseases; however, translation of phenotypes can be challenging. This paper identified 153 genes associated with heart disease in humans, 151 with a one-to-one mouse ortholog.