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This is the first stakeholder meeting of INFRAFRONTIER, the European Research Infrastructure for phenotyping and archiving of model mammalian genomes. The meeting will be jointly organized with the International Mouse Phenotyping Consortium (IMPC, www.mousephenotype.org) to which INFRAFRONTIER is contributing. Focus of this meeting is on ‘Advancing Personalised Medicine with Animal Models’. The meeting is open to a wide range of INFRAFRONTIER stakeholders including Personalised Medicine initiatives, Rare Disease networks, funders, regulators and the INFRAFRONTIER user community to discuss advances in CRISPR/Cas9 technology to model human conditions.