C57BL/6NCrl-Tbk1em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12874
Citation informationRRID:IMSR_EM:12874 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Tbk1em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolTbk1em1(IMPC)Ccpcz
Gene/Transgene symbolTbk1

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • increased monocyte cell number / MGI
  • sparse hair / MGI
  • lymphoid hyperplasia / MGI
  • skin hyperplasia / MGI
  • hyperkeratosis / MGI
  • disheveled coat / MGI
  • skin edema / MGI
  • abnormal inflammatory response / MGI
  • abnormal skin morphology / MGI
  • abnormal macrophage physiology / MGI
  • increased IgA level / MGI
  • decreased basophil cell number / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • liver degeneration / MGI
  • pallor / MGI
  • liver hemorrhage / MGI
  • skin inflammation / MGI
  • increased spleen weight / MGI
  • dermal hyperplasia / MGI
  • decreased eosinophil cell number / MGI
  • increased NK T cell number / MGI
  • decreased NK T cell number / MGI
  • increased circulating tumor necrosis factor level / MGI
  • abnormal interferon secretion / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased interferon-beta secretion / MGI
  • increased circulating interleukin-10 level / MGI
  • increased circulating interleukin-6 level / MGI
  • increased circulating interleukin-1 beta level / MGI
  • increased interleukin-6 secretion / MGI
  • abnormal cytokine level / MGI
  • increased susceptibility to endotoxin shock / MGI
  • abnormal hair cycle anagen phase / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • postnatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI

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Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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