- extramedullary hematopoiesis / MGI
- abnormal heart morphology / MGI
- enlarged heart / MGI
- abnormal coat/ hair morphology / MGI
- folliculitis / MGI
- abnormal hair follicle morphology / MGI
- abnormal auchene hair morphology / MGI
- alopecia / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- abnormal kidney blood vessel morphology / MGI
- abnormal urinary bladder morphology / MGI
- abnormal urinary bladder urothelium morphology / MGI
- abnormal liver morphology / MGI
- small liver / MGI
- pale liver / MGI
- abnormal hepatocyte morphology / MGI
- abnormal liver physiology / MGI
- abnormal branching of the mammary ductal tree / MGI
- small prostate gland anterior lobe / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal uterus morphology / MGI
- small ovary / MGI
- abnormal ovarian folliculogenesis / MGI
- seminiferous tubule degeneration / MGI
- abnormal skin condition / MGI
- scaly skin / MGI
- thick skin / MGI
- spontaneous skin ulceration / MGI
- skin lesions / MGI
- abnormal epidermal layer morphology / MGI
- increased body weight / MGI
- decreased body weight / MGI
- weight loss / MGI
- disorganized retinal layers / MGI
- abnormal blood vessel morphology / MGI
- chronic diarrhea / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- increased inflammatory response / MGI
- heart inflammation / MGI
- abnormal atrial thrombosis / MGI
- lung inflammation / MGI
- acanthosis / MGI
- reduced female fertility / MGI
- abnormal ovulation / MGI
- decreased litter size / MGI
- premature death / MGI
- decreased germ cell number / MGI
- abnormal spleen red pulp morphology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- hepatic steatosis / MGI
- abnormal cauda epididymis morphology / MGI
- decreased corpora lutea number / MGI
- colitis / MGI
- increased heart weight / MGI
- vascular smooth muscle hypertrophy / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- cardiac fibrosis / MGI
- bile duct inflammation / MGI
- gastric polyps / MGI
- increased liver adenoma incidence / MGI
- liver fibrosis / MGI
- decreased liver weight / MGI
- abnormal keratinocyte physiology / MGI
- abnormal ovary physiology / MGI
- nervous system phenotype / MGI
- abnormal hair shaft morphology / MGI
- pulmonary edema / MGI
- patent ductus venosus / MGI
- abnormal coronary artery morphology / MGI
- abnormal spermiation / MGI
- increased incidence of tumors by chemical induction / MGI
- decreased testis weight / MGI
- decreased ovary weight / MGI
- decreased seminal vesicle weight / MGI
- decreased epididymis weight / MGI
- increased spleen weight / MGI
- abnormal thrombosis / MGI
- liver hyperplasia / MGI
- increased susceptibility to injury / MGI
- abnormal Langerhans cell physiology / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- abnormal circulating hormone level / MGI
- teratozoospermia / MGI
- abnormal enzyme/coenzyme activity / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal Langerhans cell morphology / MGI
- abnormal male germ cell apoptosis / MGI
- decreased spleen white pulp amount / MGI
- decreased spleen germinal center size / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- abnormal xenobiotic pharmacokinetics / MGI
- abnormal liver sinusoid morphology / MGI
- abnormal sperm head morphology / MGI
- coiled sperm flagellum / MGI
- abnormal primordial ovarian follicle morphology / MGI
- increased urinary bladder carcinoma incidence / MGI
- hypergranulosis / MGI
- abnormal optokinetic reflex / MGI
- urinary bladder inflammation / MGI
- decreased fertilization frequency / MGI
- abnormal superovulation / MGI
- small prostate gland dorsolateral lobe / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased urine uric acid level / MGI
- increased hepatoma incidence / MGI
- abnormal stomach pyloric region morphology / MGI
- pulmonary alveolar edema / MGI
- abnormal horizontal vestibuloocular reflex / MGI
- postnatal lethality, incomplete penetrance / MGI
- cystolithiasis / MGI
- abnormal seminiferous tubule epithelium morphology / MGI
- urinary bladder fibrosis / MGI
- abnormal urinary bladder blood vessel morphology / MGI
- persistent hyaloid artery / MGI
- multinucleated giant male germ cells / MGI
- dilated piliary canal / MGI
C57BL/6NCrl-Ahrem1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:12733 |
Citation information | RRID:IMSR_EM:12733 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6NCrl-Ahrem1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Ahrem1(IMPC)Ccpcz |
Gene/Transgene symbol | Ahr |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Retinitis pigmentosa / Orphanet_791
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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