IMPC phenotypes (gene matching)
C57BL/6-Nrp1em1Cruh/H
| Status | Available to order |
| EMMA ID | EM:11988 |
| Citation information | RRID:IMSR_EM:11988 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Nrp1em1Cruh/H |
| Alternative name | Nrp1 D320K |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Nrp1em1Cruh |
| Gene/Transgene symbol | Nrp1 |
Information from provider
| Provider | Christiana Ruhrberg |
| Provider affiliation | UCL Institute of Ophthalmology, University College London |
| Genetic information | CRISPR/Cas9 technology introduced a lysine to aspartate substitution at amino acid 320 (D320K) which is predicted to abrogate VEGF164 binding to NRP1. |
| Phenotypic information | Homozygous:Nrp1-D320K/D320K mice have significantly reduced VEGF164-induced permeability.Heterozygous:-- |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal vascular development / MGI
- abnormal pulmonary artery morphology / MGI
- abnormal corpus callosum morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal facial motor nucleus morphology / MGI
- abnormal dorsal root ganglion morphology / MGI
- abnormal cranial nerve morphology / MGI
- abnormal trigeminal nerve morphology / MGI
- abnormal facial nerve morphology / MGI
- abnormal vestibulocochlear nerve morphology / MGI
- abnormal spinal nerve morphology / MGI
- decreased body size / MGI
- disorganized yolk sac vascular plexus / MGI
- postnatal growth retardation / MGI
- postnatal lethality / MGI
- premature death / MGI
- abnormal dendritic cell physiology / MGI
- abnormal T cell physiology / MGI
- persistent truncus arteriosis / MGI
- abnormal pharyngeal arch artery morphology / MGI
- abnormal retinal vasculature morphology / MGI
- abnormal axon guidance / MGI
- dilated heart atrium / MGI
- decreased tumor growth/size / MGI
- nervous system phenotype / MGI
- vascular smooth muscle hypoplasia / MGI
- transposition of great arteries / MGI
- abnormal coronary artery morphology / MGI
- right aortic arch / MGI
- double aortic arch / MGI
- abnormal dorsal aorta morphology / MGI
- abnormal brain vasculature morphology / MGI
- cardiovascular system phenotype / MGI
- vision/eye phenotype / MGI
- decreased angiogenesis / MGI
- abnormal neuronal migration / MGI
- abnormal fourth pharyngeal arch artery morphology / MGI
- abnormal sixth pharyngeal arch artery morphology / MGI
- abnormal third pharyngeal arch artery morphology / MGI
- abnormal induced retinal neovascularization / MGI
- abnormal retinal blood vessel morphology / MGI
- abnormal retinal blood vessel pattern / MGI
- abnormal first pharyngeal arch artery morphology / MGI
- abnormal second pharyngeal arch artery morphology / MGI
- abnormal aortic arch and aortic arch branch attachment / MGI
- abnormal coronary vessel morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
Literature references
- VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.;Fantin Alessandro, Lampropoulou Anastasia, Senatore Valentina, Brash James T, Prahst Claudia, Lange Clemens A, Liyanage Sidath E, Raimondi Claudio, Bainbridge James W, Augustin Hellmut G, Ruhrberg Christiana, ;2017;The Journal of experimental medicine;214;1049-1064; 28289053