C57BL/6-Nrp1em1Cruh/H
Status | Available to order |
EMMA ID | EM:11988 |
International strain name | C57BL/6-Nrp1em1Cruh/H |
Alternative name | Nrp1 D320K |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Nrp1em1Cruh, |
Gene/Transgene symbol | Nrp1 |
Information from provider
Provider | Christiana Ruhrberg |
Provider affiliation | UCL Institute of Ophthalmology, University College London |
Genetic information | CRISPR/Cas9 technology introduced a lysine to aspartate substitution at amino acid 320 (D320K) which is predicted to abrogate VEGF164 binding to NRP1. |
Phenotypic information | Homozygous:Nrp1-D320K/D320K mice have significantly reduced VEGF164-induced permeability.Heterozygous:-- |
References |
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Homozygous fertile | not known |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.;Fantin Alessandro, Lampropoulou Anastasia, Senatore Valentina, Brash James T, Prahst Claudia, Lange Clemens A, Liyanage Sidath E, Raimondi Claudio, Bainbridge James W, Augustin Hellmut G, Ruhrberg Christiana, ;2017;The Journal of experimental medicine;214;1049-1064; 28289053
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