D1.129P2(B6)-Il10tm1Cgn/JOrl
Status | Available to order |
EMMA ID | EM:11812 |
International strain name | D1.129P2(B6)-Il10tm1Cgn/JOrl |
Alternative name | D1.B6-Il10tm1Cgn/J |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Il10tm1Cgn, |
Gene/Transgene symbol | Il10 |
Information from provider
Provider | Pascale Plence |
Provider affiliation | INSERM U1183 |
Genetic information | A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. Submitted mouse strain was obtained by backcrossing strain B6.129P2-Il10tm1Cgn/J, obtained by the Jackson Laboratory (strain ref. 002251), for 10 generations on DBA/1 background and followed by 3 intercrosses. |
Phenotypic information | Homozygous:Under conventional housing conditions, Il10-deficiency is associated with altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli, increased prevalence of colorectal adenocarcinoma, and spontaneous development of chronic enterocolitis.Heterozygous:No phenotype |
Breeding history | 10 backcrosses followed by 3 intercrosses |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous DBA/1 |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome / Orphanet_238569
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