B6.129S4-Ccr1tm1Gao/Biat

Status

Available to order

EMMA IDEM:11144
Citation informationRRID:IMSR_EM:11144 

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International strain nameB6.129S4-Ccr1tm1Gao/Biat
Alternative name1-B
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCcr1tm1Gao
Gene/Transgene symbolCcr1

Information from provider

ProviderBruno Luckow
Provider affiliationNephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV
Genetic informationThe chemokine receptor Ccr1 has been inactivated by homologous recombination.
Phenotypic informationHomozygous:
Homozygous animals appear healthy and fertile and show unchallenged no obvious phenotype. Upregulated in many infectious and inflammatory diseases. Important role in leukocyte chemotaxis and innate immunity. Ccr1-deficient mice show accelerated mortality in an Aspergillus fumigatus infection model and suppression of acute and chronic cardiac allograft rejection. Phenotypic effects in hematopoiesis, host defense and inflammation.

Heterozygous:
Unknown, but most likely wild-type phenotype
Breeding historyInitially backcrossed for 6 generations to C57BL/6J and then for other 9 generations to C57BL/6NCrl genetic background. N15+F2
References
  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous Other (please specify below) males

Disease and phenotype information

MGI phenotypes (allele matching)
  • altered response to myocardial infarction / MGI
  • abnormal leukocyte adhesion / MGI
  • abnormal cellular extravasation / MGI
  • decreased mast cell number / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • abnormal Kupffer cell morphology / MGI
  • impaired hematopoiesis / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • increased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
MGI phenotypes (gene matching)
  • decreased mast cell number / MGI
  • altered response to myocardial infarction / MGI
  • impaired hematopoiesis / MGI
  • lung inflammation / MGI
  • decreased airway responsiveness / MGI
  • decreased susceptibility to viral infection / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • abnormal leukocyte adhesion / MGI
  • increased length of allograft survival / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • glomerulosclerosis / MGI
  • abnormal renal glomerulus morphology / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
  • increased blood urea nitrogen level / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal Kupffer cell morphology / MGI
  • increased IgG2a level / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • decreased circulating interferon-gamma level / MGI
  • decreased interleukin-10 secretion / MGI
  • increased interleukin-12 secretion / MGI
  • decreased interleukin-13 secretion / MGI
  • impaired neutrophil recruitment / MGI
  • abnormal chemokine secretion / MGI
  • cecum inflammation / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal cellular extravasation / MGI
  • abnormal circulating chemokine level / MGI
  • increased macrophage nitric oxide production / MGI
  • glomerular crescent / MGI

Literature references

  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

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