- altered response to myocardial infarction / MGI
- abnormal leukocyte adhesion / MGI
- abnormal cellular extravasation / MGI
- decreased mast cell number / MGI
- decreased susceptibility to type III hypersensitivity reaction / MGI
- abnormal Kupffer cell morphology / MGI
- impaired hematopoiesis / MGI
- abnormal neutrophil physiology / MGI
- granulomatous inflammation / MGI
- increased susceptibility to parasitic infection / MGI
- immune system phenotype / MGI
- increased susceptibility to fungal infection / MGI
B6.129S4-Ccr1tm1Gao/Biat
Status | Available to order |
EMMA ID | EM:11144 |
International strain name | B6.129S4-Ccr1tm1Gao/Biat |
Alternative name | 1-B |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Ccr1tm1Gao, |
Gene/Transgene symbol | Ccr1 |
Information from provider
Provider | Bruno Luckow |
Provider affiliation | Nephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV |
Genetic information | The chemokine receptor Ccr1 has been inactivated by homologous recombination. |
Phenotypic information | Homozygous:Homozygous animals appear healthy and fertile and show unchallenged no obvious phenotype. Upregulated in many infectious and inflammatory diseases. Important role in leukocyte chemotaxis and innate immunity. Ccr1-deficient mice show accelerated mortality in an Aspergillus fumigatus infection model and suppression of acute and chronic cardiac allograft rejection. Phenotypic effects in hematopoiesis, host defense and inflammation.Heterozygous:Unknown, but most likely wild-type phenotype |
Breeding history | Initially backcrossed for 6 generations to C57BL/6J and then for other 9 generations to C57BL/6NCrl genetic background. N15+F2 |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Animals used for archiving | homozygous Other (please specify below) |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).