C.129S4(B6)-Ccr1tm1Gao/Biat

Status

Available to order

EMMA IDEM:11132
Citation informationRRID:IMSR_EM:11132 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC.129S4(B6)-Ccr1tm1Gao/Biat
Alternative name1-C
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCcr1tm1Gao
Gene/Transgene symbolCcr1

Information from provider

ProviderBruno Luckow
Provider affiliationNephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV
Additional ownerOriginal Ccr1 allele was provided by Phil Murphy without any restrictions.
Genetic informationThe chemokine receptor Ccr1 has been inactivated by homologous recombination, initially backcrossed for 6 generations to the C57BL/6J and then for 14 generations to the BALB/c genetic background.
Phenotypic informationHomozygous:
Homozygous animals appear healthy and fertile and show unchallenged no obvious phenotype. Upregulated in many infectious and inflammatory diseases. Important role in leukocyte chemotaxis and innate immunity.

Heterozygous:
Unknown, but most likely wildtype phenotype.
Breeding historyCurrently maintained on the background of BALB/cAnNCrl, N14+F4
References
  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous BALB/c males

Disease and phenotype information

MGI phenotypes (allele matching)
  • altered response to myocardial infarction / MGI
  • abnormal leukocyte adhesion / MGI
  • abnormal cellular extravasation / MGI
  • decreased mast cell number / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • abnormal Kupffer cell morphology / MGI
  • impaired hematopoiesis / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • increased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
MGI phenotypes (gene matching)
  • decreased mast cell number / MGI
  • altered response to myocardial infarction / MGI
  • impaired hematopoiesis / MGI
  • lung inflammation / MGI
  • decreased airway responsiveness / MGI
  • decreased susceptibility to viral infection / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • abnormal leukocyte adhesion / MGI
  • increased length of allograft survival / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • glomerulosclerosis / MGI
  • abnormal renal glomerulus morphology / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
  • increased blood urea nitrogen level / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal Kupffer cell morphology / MGI
  • increased IgG2a level / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • decreased circulating interferon-gamma level / MGI
  • decreased interleukin-10 secretion / MGI
  • increased interleukin-12 secretion / MGI
  • decreased interleukin-13 secretion / MGI
  • impaired neutrophil recruitment / MGI
  • abnormal chemokine secretion / MGI
  • cecum inflammation / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal cellular extravasation / MGI
  • abnormal circulating chemokine level / MGI
  • increased macrophage nitric oxide production / MGI
  • glomerular crescent / MGI

Literature references

  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Example health report
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For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

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Legally binding conditions for the transfer

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