C57BL/6N-A^tm1Brd Ifnar1^{tm2a(EUCOMM)Wtsi}/WtsiOulu

Status	Available to order
EMMA ID	EM:10181
Citation information	RRID:IMSR_EM:10181 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-A^tm1Brd Ifnar1^{tm2a(EUCOMM)Wtsi}/WtsiOulu
Alternative name	MEPD01000_2_C03
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Ifnar1^{tm2a(EUCOMM)Wtsi}
Gene/Transgene symbol	Ifnar1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from EUCOMM ES clone MEPD01000_2_C03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	University of Oulu, Oulu, Finland

IMPC phenotypes (allele matching)

IMPC phenotypes (gene matching)

MGI phenotypes (gene matching)

decreased bone mineral density / MGI
increased leukocyte cell number / MGI
altered susceptibility to infection / MGI
abnormal inflammatory response / MGI
increased incidence of induced tumors / MGI
abnormal dendritic cell physiology / MGI
increased susceptibility to viral infection / MGI
abnormal macrophage physiology / MGI
abnormal immunoglobulin level / MGI
abnormal cytokine secretion / MGI
no phenotypic analysis / MGI
increased tumor growth/size / MGI
abnormal CD8-positive, alpha-beta T cell physiology / MGI
increased incidence of tumors by chemical induction / MGI
abnormal osteoclast morphology / MGI
abnormal response to infection / MGI
impaired natural killer cell mediated cytotoxicity / MGI
immune system phenotype / MGI
corneal vascularization / MGI
abnormal enzyme/coenzyme activity / MGI
decreased NK cell number / MGI
abnormal interferon-gamma secretion / MGI
decreased tumor necrosis factor secretion / MGI
decreased interferon-alpha secretion / MGI
decreased interferon-beta secretion / MGI
increased circulating interleukin-12 level / MGI
decreased interleukin-6 secretion / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI
abnormal NK cell physiology / MGI

Information from provider