B6.129P2-Stat1tm1.1Mmul/Biat

Status

Available to order

EMMA IDEM:09906
Citation informationRRID:IMSR_EM:09906 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129P2-Stat1tm1.1Mmul/Biat
Alternative nameB6.129P2-Stat1
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolStat1tm1.1Mmul
Gene/Transgene symbolStat1

Information from provider

ProviderMathias Müller
Provider affiliationDepartment for Biomedical Sciences, University of Veterinary Medicine Vienna (Vetmeduni Vienna)
Additional ownerProf. Thomas Rülicke, University of Veterinary Medicine, Institute of Laboratory Animal Science, Vienna, Austria
Genetic informationA loxP site was inserted upstream of exon 6. A floxed neo cassette was inserted downstream of exon 10. Cre-mediated recombination removed the neo cassette and left exons 6 through 10 floxed. (J:183580)
Phenotypic informationHomozygous:
none

Heterozygous:
none
References
  • Generation of mice with a conditional Stat1 null allele.;Wallner Barbara, Leitner Nicole R, Vielnascher Raimund M, Kernbauer Elisabeth, Kolbe Thomas, Karaghiosoff Marina, Rülicke Thomas, Decker Thomas, Müller Mathias, ;2012;Transgenic research;21;217-24; 21553074
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous C57BL/6.129P2/OlaHsd males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased monocyte cell number / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased neutrophil cell number / IMPC
  • increased lymphocyte cell number / IMPC
  • abnormal gait / IMPC
  • impaired righting response / IMPC
  • decreased mean corpuscular volume / IMPC
  • enlarged lymph nodes / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased bone mineral content / IMPC
  • increased leukocyte cell number / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • increased large unstained cell number / IMPC
  • increased eosinophil cell number / IMPC
  • increased basophil cell number / IMPC
MGI phenotypes (gene matching)
  • abnormal intestine morphology / MGI
  • abnormal tibia morphology / MGI
  • decreased body size / MGI
  • abnormal cornea morphology / MGI
  • multifocal hepatic necrosis / MGI
  • abnormal T cell activation / MGI
  • decreased level of surface class I molecules / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to bacterial infection / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal leukocyte physiology / MGI
  • abnormal macrophage physiology / MGI
  • increased IgG level / MGI
  • increased myocardial infarction size / MGI
  • abnormal cell cycle / MGI
  • abnormal redox activity / MGI
  • increased cardiomyocyte apoptosis / MGI
  • abnormal nitric oxide homeostasis / MGI
  • increased compact bone thickness / MGI
  • decreased B-1 B cell number / MGI
  • increased osteoclast cell number / MGI
  • increased bone resorption / MGI
  • decreased B cell number / MGI
  • abnormal response to infection / MGI
  • abnormal MHC II cell surface expression on macrophages / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • immune system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal T-helper 2 physiology / MGI
  • increased bone mass / MGI
  • abnormal cell physiology / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • increased NK T cell number / MGI
  • decreased NK cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • decreased susceptibility to neuronal excitotoxicity / MGI
  • abnormal osteoblast differentiation / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased interferon-gamma secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • decreased circulating interferon-gamma level / MGI
  • increased circulating interleukin-12b level / MGI
  • decreased interleukin-1 beta secretion / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • decreased NK cell degranulation / MGI
  • decreased hepatocyte apoptosis / MGI
  • decreased sensitivity to induced cell death / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • tumor regression / MGI
  • abnormal NK cell physiology / MGI
  • increased effector memory CD8-positive, alpha-beta T cell number / MGI
  • increased trabecular bone volume / MGI
  • increased compact bone volume / MGI
  • increased macrophage nitric oxide production / MGI
  • lethality at weaning, complete penetrance / MGI
  • abnormal CD8-positive, naive alpha-beta T cell number / MGI

Literature references

  • Generation of mice with a conditional Stat1 null allele.;Wallner Barbara, Leitner Nicole R, Vielnascher Raimund M, Kernbauer Elisabeth, Kolbe Thomas, Karaghiosoff Marina, Rülicke Thomas, Decker Thomas, Müller Mathias, ;2012;Transgenic research;21;217-24; 21553074

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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