- abnormal trabecular bone morphology / MGI
- abnormal circulating serum albumin level / MGI
- absent erythroid progenitor cell / MGI
- increased granulocyte number / MGI
- abnormal enterocyte morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal large intestine morphology / MGI
- abnormal crypts of Lieberkuhn morphology / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal liver physiology / MGI
- spleen hyperplasia / MGI
- thymus hyperplasia / MGI
- abnormal lymphocyte cell number / MGI
- decreased body weight / MGI
- impaired coordination / MGI
- abnormal sleep pattern / MGI
- abnormal skeleton physiology / MGI
- abnormal lipid level / MGI
- abnormal circulating enzyme level / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- postnatal growth retardation / MGI
- abnormal homeostasis / MGI
- abnormal iron level / MGI
- abnormal immune system physiology / MGI
- abnormal inflammatory response / MGI
- intestinal inflammation / MGI
- abnormal reproductive system physiology / MGI
- increased thermal nociceptive threshold / MGI
- decreased tumor incidence / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- abnormal hypersensitivity reaction / MGI
- no abnormal phenotype detected / MGI
- decreased airway responsiveness / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal innate immunity / MGI
- increased IgE level / MGI
- chronic inflammation / MGI
- abnormal type IV hypersensitivity reaction / MGI
- enhanced wound healing / MGI
- decreased circulating insulin level / MGI
- microcytic anemia / MGI
- colitis / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- increased insulin sensitivity / MGI
- abnormal bone mineralization / MGI
- increased intestinal adenocarcinoma incidence / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- increased vasoconstriction / MGI
- decreased vasoconstriction / MGI
- increased myocardial infarction size / MGI
- short femur / MGI
- large intestinal inflammation / MGI
- small intestinal inflammation / MGI
- decreased susceptibility to induced choroidal neovascularization / MGI
- abnormal bone structure / MGI
- increased hepatocyte apoptosis / MGI
- abnormal nitric oxide homeostasis / MGI
- decreased circulating iron level / MGI
- decreased incidence of tumors by UV induction / MGI
- decreased length of allograft survival / MGI
- abnormal neuron physiology / MGI
- decreased mean systemic arterial blood pressure / MGI
- abnormal regulatory T cell physiology / MGI
- increased thymus weight / MGI
- decreased bone strength / MGI
- increased B cell number / MGI
- increased T cell number / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal level of surface class II molecules / MGI
- decreased T cell proliferation / MGI
- cachexia / MGI
- increased circulating cholesterol level / MGI
- decreased circulating cholesterol level / MGI
- increased fatty acid level / MGI
- abnormal Langerhans cell physiology / MGI
- immune system phenotype / MGI
- abnormal circulating protein level / MGI
- abnormal skeleton morphology / MGI
- decreased circulating creatinine level / MGI
- increased susceptibility to type IV hypersensitivity reaction / MGI
- increased cerebral infarction size / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased plasma cell number / MGI
- increased myeloid dendritic cell number / MGI
- increased susceptibility to neuronal excitotoxicity / MGI
- abnormal leukocyte morphology / MGI
- abnormal myeloid leukocyte morphology / MGI
- hypochromic anemia / MGI
- abnormal osteoblast differentiation / MGI
- abnormal protein level / MGI
- decreased spleen red pulp amount / MGI
- slow postnatal weight gain / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased susceptibility to induced colitis / MGI
- increased circulating tumor necrosis factor level / MGI
- increased interferon-gamma secretion / MGI
- increased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- abnormal circulating interleukin-6 level / MGI
- increased circulating interleukin-6 level / MGI
- increased circulating interleukin-2 level / MGI
- increased circulating interleukin-17 level / MGI
- increased circulating interleukin-12 level / MGI
- increased circulating interleukin-1 alpha level / MGI
- increased circulating interleukin-1 beta level / MGI
- abnormal circulating interleukin-12b level / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- increased susceptibility to endotoxin shock / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased spleen iron level / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased large intestine adenocarcinoma incidence / MGI
- increased colon adenocarcinoma incidence / MGI
- decreased trabecular bone thickness / MGI
- increased liver triglyceride level / MGI
- cecum inflammation / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased leukotriene level / MGI
- decreased bone mineral content / MGI
- abnormal intestine physiology / MGI
- decreased bone trabecula number / MGI
- decreased trabecular bone mass / MGI
- decreased compact bone mass / MGI
- impaired adaptive thermogenesis / MGI
- increased placental labyrinth size / MGI
- impaired exercise endurance / MGI
- alveolar process atrophy / MGI
STOCK Il10tm1a(EUCOMM)Wtsi/Cnbc
Status | Available to order |
EMMA ID | EM:08502 |
Citation information | RRID:IMSR_EM:08502 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | STOCK Il10tm1a(EUCOMM)Wtsi/Cnbc |
Alternative name | STOCK.Il10 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Il10tm1a(EUCOMM)Wtsi |
Gene/Transgene symbol | Il10 |
Information from provider
Provider | Aurora Pujol |
Provider affiliation | Neurosciences. Neurometabolic Diseases, IDIBELL |
Genetic information | Heterozygous mice, carrying a genetically modified tm1a allele of the Il10 gene (produced by EUCOMM; ES cell clone EPD0158_4_D06), were produced at CNB-CSIC, under Infrafrontier-I3 project (WP8 work-package). GLT chimera bred to albino outbred mice. Resulting animals further bred to CD1 for archiving purposes, resulting in a STOCK (albino outbred) genetic background. |
Phenotypic information | Homozygous:None, unless the gene is deleted via cre-loxP strategies.Heterozygous:none |
Breeding history | ES cells from C57BL/6N genetic background resulting in a GLT chimera bred to albino outbred animals. Resulting animals bred to CD1 albino outbred mice for archiving purposes. Mixed background. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous mixed males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome / Orphanet_238569
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).