IMPC phenotypes (gene matching)
C3HeB/FeJ-Myd88m1Hmgu/Ieg
| Status | Available to order |
| EMMA ID | EM:06164 |
| International strain name | C3HeB/FeJ-Myd88m1Hmgu/Ieg |
| Alternative name | C3HeB/FeJ-Myd88Asp263Gly |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Myd88m1Hmgu |
| Gene/Transgene symbol | Myd88 |
Information from provider
| Provider | Sibylle Sabrautzki |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | c.788A>G, p.Asp263Gly |
| Phenotypic information | unknown |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Waldenström macroglobulinemia / Orphanet_33226
- Bacterial susceptibility due to TLR signaling pathway deficiency / Orphanet_183713
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- abnormal enterocyte morphology / MGI
- increased body weight / MGI
- hyperglycemia / MGI
- abnormal immune system physiology / MGI
- decreased IgG level / MGI
- decreased inflammatory response / MGI
- abnormal glucose homeostasis / MGI
- abnormal respiratory system physiology / MGI
- abnormal airway responsiveness / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal innate immunity / MGI
- abnormal adaptive immunity / MGI
- abnormal cell-mediated immunity / MGI
- abnormal T cell physiology / MGI
- abnormal macrophage physiology / MGI
- abnormal neutrophil physiology / MGI
- increased IgA level / MGI
- increased IgE level / MGI
- decreased mean corpuscular volume / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- rectal hemorrhage / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal nervous system physiology / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased incidence of tumors by chemical induction / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal response to infection / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased B cell proliferation / MGI
- abnormal pancreatic beta cell morphology / MGI
- digestive/alimentary phenotype / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased circulating aspartate transaminase level / MGI
- increased apoptosis / MGI
- abnormal retinal progenitor cell morphology / MGI
- abnormal susceptibility to hearing loss / MGI
- abnormal NK T cell physiology / MGI
- abnormal dendritic cell differentiation / MGI
- increased dendritic cell number / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased IgG1 level / MGI
- increased susceptibility to induced colitis / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-alpha secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-10 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-12b level / MGI
- decreased interleukin-1 beta secretion / MGI
- decreased interleukin-10 secretion / MGI
- decreased interleukin-12 secretion / MGI
- decreased interleukin-12b secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- abnormal chemokine secretion / MGI
- abnormal interferon level / MGI
- abnormal tumor necrosis factor level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal enterocyte physiology / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- abnormal neuron differentiation / MGI
- decreased liver tumor incidence / MGI
- abnormal gut flora balance / MGI
- abnormal NK cell physiology / MGI
- altered susceptibility to bacterial infection / MGI