IMPC phenotypes (gene matching)
C3HeB/FeJ-Myd88m1Hmgu/Ieg
| Status | Available to order |
| EMMA ID | EM:06164 |
| Citation information | RRID:IMSR_EM:06164 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3HeB/FeJ-Myd88m1Hmgu/Ieg |
| Alternative name | C3HeB/FeJ-Myd88Asp263Gly |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Myd88m1Hmgu |
| Gene/Transgene symbol | Myd88 |
Information from provider
| Provider | Sibylle Sabrautzki |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | c.788A>G, p.Asp263Gly |
| Phenotypic information | unknown |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Waldenström macroglobulinemia / Orphanet_33226
- Bacterial susceptibility due to TLR signaling pathway deficiency / Orphanet_183713
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- abnormal enterocyte morphology / MGI
- increased body weight / MGI
- hyperglycemia / MGI
- abnormal immune system physiology / MGI
- decreased IgG level / MGI
- decreased inflammatory response / MGI
- abnormal glucose homeostasis / MGI
- abnormal respiratory system physiology / MGI
- abnormal airway responsiveness / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal innate immunity / MGI
- abnormal adaptive immunity / MGI
- abnormal cell-mediated immunity / MGI
- abnormal T cell physiology / MGI
- abnormal macrophage physiology / MGI
- abnormal neutrophil physiology / MGI
- increased IgA level / MGI
- increased IgE level / MGI
- decreased mean corpuscular volume / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- rectal hemorrhage / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal nervous system physiology / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased incidence of tumors by chemical induction / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal response to infection / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased B cell proliferation / MGI
- abnormal pancreatic beta cell morphology / MGI
- digestive/alimentary phenotype / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased circulating aspartate transaminase level / MGI
- increased apoptosis / MGI
- abnormal retinal progenitor cell morphology / MGI
- abnormal susceptibility to hearing loss / MGI
- abnormal NK T cell physiology / MGI
- abnormal dendritic cell differentiation / MGI
- increased dendritic cell number / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased IgG1 level / MGI
- increased susceptibility to induced colitis / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-alpha secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-10 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-12b level / MGI
- decreased interleukin-1 beta secretion / MGI
- decreased interleukin-10 secretion / MGI
- decreased interleukin-12 secretion / MGI
- decreased interleukin-12b secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- abnormal chemokine secretion / MGI
- abnormal interferon level / MGI
- abnormal tumor necrosis factor level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal enterocyte physiology / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- abnormal neuron differentiation / MGI
- decreased liver tumor incidence / MGI
- abnormal gut flora balance / MGI
- abnormal NK cell physiology / MGI
- altered susceptibility to bacterial infection / MGI