C57BL/6NTac-Furintm1a(EUCOMM)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:04412
Citation informationRRID:IMSR_EM:04412 

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International strain nameC57BL/6NTac-Furintm1a(EUCOMM)Wtsi/Cnrm
Alternative nameEPD0127_1_A12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFurintm1a(EUCOMM)Wtsi
Gene/Transgene symbolFurin
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0127_1_A12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Animals used for archivingheterozygous C57BL/6NTac males, wild-type C57BL/6NTac females
Stage of embryos2-cell

Disease and phenotype information

IMPC phenotypes (gene matching)
  • embryonic lethality prior to tooth bud stage / IMPC
  • abnormal vibrissa morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • brachydactyly / IMPC
MGI phenotypes (gene matching)
  • abnormal heart development / MGI
  • abnormal heart tube morphology / MGI
  • exencephaly / MGI
  • abnormal somite shape / MGI
  • decreased embryo size / MGI
  • abnormal dorsal-ventral axis patterning / MGI
  • absent vitelline blood vessels / MGI
  • abnormal allantois morphology / MGI
  • abnormal developmental patterning / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal ventral body wall morphology / MGI
  • kinked neural tube / MGI
  • failure of initiation of embryo turning / MGI
  • cardia bifida / MGI
  • failure of heart looping / MGI
  • abnormal cardinal vein morphology / MGI
  • abnormal neural plate morphology / MGI
  • failure of chorioallantoic fusion / MGI
  • absent midgut / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal visceral yolk sac blood island morphology / MGI
  • excessive folding of visceral yolk sac / MGI
  • decreased somite size / MGI
  • short rostral-caudal axis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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