IMPC phenotypes (gene matching)
C57BL/6-Dpp4tm1Nwa/Orl
| Status | Available to order |
| EMMA ID | EM:02577 |
| International strain name | C57BL/6-Dpp4tm1Nwa/Orl |
| Alternative name | C57Bl/6_DPP4-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Dpp4tm1Nwa |
| Gene/Transgene symbol | Dpp4 |
Information from provider
| Provider | Didier MARGUET |
| Provider affiliation | Centre D |
| Genetic information | Deletion in the CD26/Dpp4 gene which inactivated the expression of the DPP4 enzyme. A 2.3-kb PstI-SphI fragment containing exons 1 and 2, was replaced with the non floxed PGKNeo cassette. |
| Phenotypic information | Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26/Dpp4. |
| Breeding history | Since its origin, the strain has been inbred on C57BL/6 strain. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J |
| Breeding at archiving centre | We have frozen sperm under two protocols: - MTG protocol (heterozygous males) - CARD protocol (homozygous males). Please inform us if you have a preference for one of them when you submit a request. |
Disease and phenotype information
Literature references
- Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.;Marguet D, Baggio L, Kobayashi T, Bernard A M, Pierres M, Nielsen P F, Ribel U, Watanabe T, Drucker D J, Wagtmann N, ;2000;Proceedings of the National Academy of Sciences of the United States of America;97;6874-9; 10823914
- Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion.;Patarrão Rita S, Duarte Nádia, Coelho Inês, Ward Joey, Ribeiro Rogério T, Meneses Maria João, Andrade Rita, Costa João, Correia Isabel, Boavida José Manuel, Duarte Rui, Gardete-Correia Luís, Medina José Luís, Pell Jill, Petrie John, Raposo João F, Macedo Maria Paula, Penha-Gonçalves Carlos, ;2022;Diabetologia;65;861-871; 35190847
- Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis.;Hammad Seddik, Hoehme Stefan, Friebel Adrian, von Recklinghausen Iris, Othman Amnah, Begher-Tibbe Brigitte, Reif Raymond, Godoy Patricio, Johann Tim, Vartak Amruta, Golka Klaus, Bucur Petru O, Vibert Eric, Marchan Rosemarie, Christ Bruno, Dooley Steven, Meyer Christoph, Ilkavets Iryna, Dahmen Uta, Dirsch Olaf, Böttger Jan, Gebhardt Rolf, Drasdo Dirk, Hengstler Jan G, ;2014;Archives of toxicology;88;1161-83; 24748404
- Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells.;Duarte Nádia, Coelho Inês, Holovanchuk Denys, Inês Almeida Joana, Penha-Gonçalves Carlos, Paula Macedo Maria, ;2018;Hepatology communications;2;1080-1094; 30202822