IMPC phenotypes (gene matching)
C57BL/10ScCrOrl
| Status | Available to order |
| EMMA ID | EM:00035 |
| International strain name | C57BL/10ScCrOrl |
| Alternative name | C57BL/10ScCR |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Tlr4lps-del |
| Gene/Transgene symbol | Tlr4 |
Information from provider
| Provider | Francois Huetz |
| Provider affiliation | Bat. Metchnikoff, Inst. Pasteur |
| Phenotypic information | Mutant strain carrying an intrinsic Tlr4 deletion (Tlr4: toll-like receptor 4; prev. nomenclature: Lps). No response to Lipopolysaccharide (LPS). |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased thermal nociceptive threshold / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- abnormal cytokine secretion / MGI
- abnormal glial cell physiology / MGI
- decreased response of heart to induced stress / MGI
- decreased susceptibility to injury / MGI
- hyporesponsive to tactile stimuli / MGI
- abnormal retinal rod cell morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal pulmonary alveolar duct morphology / MGI
- rectal hemorrhage / MGI
- abnormal retinal layer morphology / MGI
- enlarged lung / MGI
- increased spleen weight / MGI
- abnormal retinal pigment epithelium morphology / MGI
- decreased percent body fat/body weight / MGI
- increased bone mass / MGI
- abnormal retinal progenitor cell morphology / MGI
- abnormal retinal rod bipolar cell morphology / MGI
- increased bone mineral content / MGI
- abnormal circulating enzyme level / MGI
- decreased circulating alanine transaminase level / MGI
- CNS ischemia / MGI
- decreased interleukin-10 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal tumor necrosis factor level / MGI
- abnormal neuron differentiation / MGI
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal circulating glucose level / MGI
- cellular necrosis / MGI
- abnormal hepatocyte morphology / MGI
- abnormal liver physiology / MGI
- enlarged lymph nodes / MGI
- abnormal retinal rod cell morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal locomotor behavior / MGI
- abnormal motor coordination/balance / MGI
- abnormal lipid level / MGI
- abnormal circulating enzyme level / MGI
- focal hepatic necrosis / MGI
- altered susceptibility to infection / MGI
- abnormal inflammatory response / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- increased thermal nociceptive threshold / MGI
- abnormal glucose homeostasis / MGI
- abnormal respiratory system morphology / MGI
- abnormal respiratory system physiology / MGI
- no abnormal phenotype detected / MGI
- abnormal artery morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal pulmonary alveolar duct morphology / MGI
- abnormal airway responsiveness / MGI
- decreased susceptibility to viral infection / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- abnormal acute inflammation / MGI
- abnormal renal tubule morphology / MGI
- dilated renal tubules / MGI
- decreased circulating insulin level / MGI
- decreased hemoglobin content / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- decreased neuron apoptosis / MGI
- abnormal pulmonary elastic fiber morphology / MGI
- rectal hemorrhage / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal intestinal goblet cell morphology / MGI
- abnormal nervous system morphology / MGI
- abnormal glial cell physiology / MGI
- abnormal microglial cell physiology / MGI
- increased susceptibility to induced arthritis / MGI
- abnormal retinal layer morphology / MGI
- abnormal bone structure / MGI
- pulmonary edema / MGI
- abnormal myelin sheath morphology / MGI
- abnormal nephron morphology / MGI
- abnormal gas homeostasis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- abnormal muscle cell glucose uptake / MGI
- renal tubular necrosis / MGI
- decreased response of heart to induced stress / MGI
- decreased incidence of tumors by chemical induction / MGI
- abnormal bile salt level / MGI
- enlarged lung / MGI
- abnormal vascular wound healing / MGI
- increased adiponectin level / MGI
- abnormal spleen weight / MGI
- increased spleen weight / MGI
- decreased B cell number / MGI
- abnormal level of surface class II molecules / MGI
- decreased acute inflammation / MGI
- decreased B cell proliferation / MGI
- decreased susceptibility to injury / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal fatty acid level / MGI
- increased oxygen consumption / MGI
- improved glucose tolerance / MGI
- atherosclerotic lesions / MGI
- muscle phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- digestive/alimentary phenotype / MGI
- immune system phenotype / MGI
- respiratory system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased percent body fat/body weight / MGI
- abnormal T-helper 2 physiology / MGI
- hyporesponsive to tactile stimuli / MGI
- decreased body temperature / MGI
- decreased angiogenesis / MGI
- increased bone mass / MGI
- abnormal circulating leptin level / MGI
- decreased cerebral infarction size / MGI
- decreased susceptibility to ischemic brain injury / MGI
- abnormal retinal progenitor cell morphology / MGI
- abnormal retinal rod bipolar cell morphology / MGI
- CNS ischemia / MGI
- abnormal phagocyte morphology / MGI
- abnormal osteoclast differentiation / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-beta secretion / MGI
- increased circulating interleukin-6 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased interleukin-1 beta secretion / MGI
- decreased interleukin-10 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- impaired neutrophil chemotaxis / MGI
- decreased memory B cell number / MGI
- decreased susceptibility to endotoxin shock / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- abnormal enterocyte proliferation / MGI
- decreased hepatocyte apoptosis / MGI
- decreased fat cell size / MGI
- decreased epididymal fat pad weight / MGI
- decreased liver triglyceride level / MGI
- abnormal renal tubule epithelium morphology / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- decreased susceptibility to bone fracture / MGI
- abnormal neuron differentiation / MGI
- increased bone mineral content / MGI
- abnormal enterocyte differentiation / MGI
- abnormal glial cell apoptosis / MGI
- decreased susceptibility to weight loss / MGI
- decreased respiratory quotient / MGI
- abnormal macrophage chemotaxis / MGI
- increased lung compliance / MGI
- dilated pulmonary alveolar ducts / MGI
- decreased macrophage cytokine production / MGI
- decreased macrophage apoptosis / MGI
- abnormal proximal convoluted tubule brush border morphology / MGI
- renal cast / MGI
- abnormal fibroblast proliferation / MGI
- increased cell death / MGI
Literature references
- Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.;Coutinho A, Forni L, Melchers F, Watanabe T, ;1977;European journal of immunology;7;325-8; 326565