- increased thermal nociceptive threshold / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- abnormal cytokine secretion / MGI
- abnormal glial cell physiology / MGI
- decreased response of heart to induced stress / MGI
- decreased susceptibility to injury / MGI
- hyporesponsive to tactile stimuli / MGI
- abnormal retinal rod cell morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal pulmonary alveolar duct morphology / MGI
- rectal hemorrhage / MGI
- abnormal retinal layer morphology / MGI
- enlarged lung / MGI
- increased spleen weight / MGI
- abnormal retinal pigment epithelium morphology / MGI
- decreased percent body fat/body weight / MGI
- increased bone mass / MGI
- abnormal retinal progenitor cell morphology / MGI
- abnormal retinal rod bipolar cell morphology / MGI
- increased bone mineral content / MGI
- abnormal circulating enzyme level / MGI
- decreased circulating alanine transaminase level / MGI
- CNS ischemia / MGI
- decreased interleukin-10 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal tumor necrosis factor level / MGI
- abnormal neuron differentiation / MGI
C57BL/10ScCrOrl
Status | Available to order |
EMMA ID | EM:00035 |
International strain name | C57BL/10ScCrOrl |
Alternative name | C57BL/10ScCR |
Strain type | Spontaneous |
Allele/Transgene symbol | Tlr4lps-del, |
Gene/Transgene symbol | Tlr4 |
Information from provider
Provider | Francois Huetz |
Provider affiliation | Bat. Metchnikoff, Inst. Pasteur |
Phenotypic information | Mutant strain carrying an intrinsic Tlr4 deletion (Tlr4: toll-like receptor 4; prev. nomenclature: Lps). No response to Lipopolysaccharide (LPS). |
References |
|
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.;Coutinho A, Forni L, Melchers F, Watanabe T, ;1977;European journal of immunology;7;325-8; 326565
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).