C57BL/10ScCrOrl
Status | Available to order |
EMMA ID | EM:00035 |
Citation information | RRID:IMSR_EM:00035 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/10ScCrOrl |
Alternative name | C57BL/10ScCR |
Strain type | Spontaneous |
Allele/Transgene symbol | Tlr4lps-del |
Gene/Transgene symbol | Tlr4 |
Information from provider
Provider | Francois Huetz |
Provider affiliation | Bat. Metchnikoff, Inst. Pasteur |
Phenotypic information | Mutant strain carrying an intrinsic Tlr4 deletion (Tlr4: toll-like receptor 4; prev. nomenclature: Lps). No response to Lipopolysaccharide (LPS). |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- increased thermal nociceptive threshold / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- abnormal cytokine secretion / MGI
- abnormal glial cell physiology / MGI
- decreased response of heart to induced stress / MGI
- decreased susceptibility to injury / MGI
- hyporesponsive to tactile stimuli / MGI
- abnormal retinal rod cell morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal pulmonary alveolar duct morphology / MGI
- rectal hemorrhage / MGI
- abnormal retinal layer morphology / MGI
- enlarged lung / MGI
- increased spleen weight / MGI
- abnormal retinal pigment epithelium morphology / MGI
- decreased percent body fat/body weight / MGI
- increased bone mass / MGI
- abnormal retinal progenitor cell morphology / MGI
- abnormal retinal rod bipolar cell morphology / MGI
- increased bone mineral content / MGI
- abnormal circulating enzyme level / MGI
- decreased circulating alanine transaminase level / MGI
- CNS ischemia / MGI
- decreased interleukin-10 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal tumor necrosis factor level / MGI
- abnormal neuron differentiation / MGI
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal circulating glucose level / MGI
- cellular necrosis / MGI
- abnormal hepatocyte morphology / MGI
- abnormal liver physiology / MGI
- enlarged lymph nodes / MGI
- abnormal retinal rod cell morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal locomotor behavior / MGI
- abnormal motor coordination/balance / MGI
- abnormal lipid level / MGI
- abnormal circulating enzyme level / MGI
- focal hepatic necrosis / MGI
- altered susceptibility to infection / MGI
- abnormal inflammatory response / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- increased thermal nociceptive threshold / MGI
- abnormal glucose homeostasis / MGI
- abnormal respiratory system morphology / MGI
- abnormal respiratory system physiology / MGI
- no abnormal phenotype detected / MGI
- abnormal artery morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal pulmonary alveolar duct morphology / MGI
- abnormal airway responsiveness / MGI
- decreased susceptibility to viral infection / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- abnormal acute inflammation / MGI
- abnormal renal tubule morphology / MGI
- dilated renal tubules / MGI
- decreased circulating insulin level / MGI
- decreased hemoglobin content / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- decreased neuron apoptosis / MGI
- abnormal pulmonary elastic fiber morphology / MGI
- rectal hemorrhage / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal intestinal goblet cell morphology / MGI
- abnormal nervous system morphology / MGI
- abnormal glial cell physiology / MGI
- abnormal microglial cell physiology / MGI
- increased susceptibility to induced arthritis / MGI
- abnormal retinal layer morphology / MGI
- abnormal bone structure / MGI
- pulmonary edema / MGI
- abnormal myelin sheath morphology / MGI
- abnormal nephron morphology / MGI
- abnormal gas homeostasis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- abnormal muscle cell glucose uptake / MGI
- renal tubular necrosis / MGI
- decreased response of heart to induced stress / MGI
- decreased incidence of tumors by chemical induction / MGI
- abnormal bile salt level / MGI
- enlarged lung / MGI
- abnormal vascular wound healing / MGI
- increased adiponectin level / MGI
- abnormal spleen weight / MGI
- increased spleen weight / MGI
- decreased B cell number / MGI
- abnormal level of surface class II molecules / MGI
- decreased acute inflammation / MGI
- decreased B cell proliferation / MGI
- decreased susceptibility to injury / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal fatty acid level / MGI
- increased oxygen consumption / MGI
- improved glucose tolerance / MGI
- atherosclerotic lesions / MGI
- muscle phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- digestive/alimentary phenotype / MGI
- immune system phenotype / MGI
- respiratory system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased percent body fat/body weight / MGI
- abnormal T-helper 2 physiology / MGI
- hyporesponsive to tactile stimuli / MGI
- decreased body temperature / MGI
- decreased angiogenesis / MGI
- increased bone mass / MGI
- abnormal circulating leptin level / MGI
- decreased cerebral infarction size / MGI
- decreased susceptibility to ischemic brain injury / MGI
- abnormal retinal progenitor cell morphology / MGI
- abnormal retinal rod bipolar cell morphology / MGI
- CNS ischemia / MGI
- abnormal phagocyte morphology / MGI
- abnormal osteoclast differentiation / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-beta secretion / MGI
- increased circulating interleukin-6 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased interleukin-1 beta secretion / MGI
- decreased interleukin-10 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- impaired neutrophil chemotaxis / MGI
- decreased memory B cell number / MGI
- decreased susceptibility to endotoxin shock / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- abnormal enterocyte proliferation / MGI
- decreased hepatocyte apoptosis / MGI
- decreased fat cell size / MGI
- decreased epididymal fat pad weight / MGI
- decreased liver triglyceride level / MGI
- abnormal renal tubule epithelium morphology / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- decreased susceptibility to bone fracture / MGI
- abnormal neuron differentiation / MGI
- increased bone mineral content / MGI
- abnormal enterocyte differentiation / MGI
- abnormal glial cell apoptosis / MGI
- decreased susceptibility to weight loss / MGI
- decreased respiratory quotient / MGI
- abnormal macrophage chemotaxis / MGI
- increased lung compliance / MGI
- dilated pulmonary alveolar ducts / MGI
- decreased macrophage cytokine production / MGI
- decreased macrophage apoptosis / MGI
- abnormal proximal convoluted tubule brush border morphology / MGI
- renal cast / MGI
- abnormal fibroblast proliferation / MGI
- increased cell death / MGI
Literature references
- Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.;Coutinho A, Forni L, Melchers F, Watanabe T, ;1977;European journal of immunology;7;325-8; 326565
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