- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- abnormal immune system cell morphology / MGI
- hemolytic anemia / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- autoimmune response / MGI
- reduced fertility / MGI
- premature death / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal dendritic cell physiology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal dendritic cell antigen presentation / MGI
- abnormal B cell physiology / MGI
- abnormal immunoglobulin level / MGI
- increased IgM level / MGI
- abnormal immune system organ morphology / MGI
- increased urine protein level / MGI
- abnormal cytokine secretion / MGI
- abnormal artery development / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal lymphocyte physiology / MGI
- insulitis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-single stranded DNA antibody level / MGI
- increased anti-erythrocyte antigen antibody level / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to experimental autoimmune myasthenia gravis / MGI
- decreased regulatory T cell number / MGI
- increased B cell number / MGI
- decreased susceptibility to parasitic infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal level of surface class II molecules / MGI
- increased double-negative T cell number / MGI
- decreased susceptibility to autoimmune disorder / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- abnormal response to transplant / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interleukin-12 secretion / MGI
- abnormal lymph node cell ratio / MGI
- abnormal neuron proliferation / MGI
B6.129S2-H2-Ab1tm1Doi/DoiOrl
Status | Available to order |
EMMA ID | EM:00004 |
International strain name | B6.129S2-H2-Ab1tm1Doi/DoiOrl |
Alternative name | Abeta° |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | H2-Ab1b-tm1Doi |
Gene/Transgene symbol | H2-Ab1 |
Information from provider
Provider | Diane MATHIS |
Provider affiliation | LGME Universite |
Phenotypic information | Mutant mice deficient in histocompatibility 2, class II antigen A, beta 1 (MHC class II A beta, H2-Ab1) gene. H2-Ab1 gene mutation obtained by homologous recombination (insertion of neomycin-resistance gene cassette into the second exon) in ES cells from 129S2/SvPas, yet deficient in the MHC complex. The animals show a complete lack of class II molecules and an almost total absence of CD4+ lymphocytes. Immune responses are much altered or lacking. |
Breeding history | 129S2/SvPas ES cells; 9 generations of backcross with C57BL/6, then intercross. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Mice lacking MHC class II molecules.;Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D, ;1991;Cell;66;1051-66; 1909605
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