MGI phenotypes (allele matching)
129-Il1rl1tm1Brl/ZbzCnrm
| Status | Available to order |
| EMMA ID | EM:00002 |
| International strain name | 129-Il1rl1tm1Brl/ZbzCnrm |
| Alternative name | 129TgH(GS-T1)Brl |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Il1rl1tm1Brl |
| Gene/Transgene symbol | Il1rl1 |
Information from provider
| Provider | Karin Senn |
| Provider affiliation | Institute of Experimental Immunology, Institute of Experimental Immunology |
| Genetic information | Deletion of Il1rl1 (T1/ST2) gene; mice express the lacZ gene under the T1/ST2 promoter. |
| Phenotypic information | For mast cells and T helper 2 (Th2) cells no phenotypic alterations found so far; functional properties under investigation. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Animals used for archiving | homozygous 129S/SvEv, wild-type 129S/SvEv |
| Stage of embryos | 8-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
- abnormal eosinophil physiology / MGI
- decreased IgE level / MGI
- granulomatous inflammation / MGI
- increased susceptibility to induced pancreatitis / MGI
- increased eosinophil cell number / MGI
- decreased eosinophil cell number / MGI
- abnormal response to infection / MGI
- abnormal T-helper 2 physiology / MGI
- abnormal interleukin secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased interleukin-5 secretion / MGI
Literature references
- T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882
- The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.;Reichenbach Dawn K, Schwarze Vincent, Matta Benjamin M, Tkachev Victor, Lieberknecht Elisabeth, Liu Quan, Koehn Brent H, Pfeifer Dietmar, Taylor Patricia A, Prinz Gabriele, Dierbach Heide, Stickel Natalie, Beck Yvonne, Warncke Max, Junt Tobias, Schmitt-Graeff Annette, Nakae Susumu, Follo Marie, Wertheimer Tobias, Schwab Lukas, Devlin Jason, Watkins Simon C, Duyster Justus, Ferrara James L M, Turnquist Heth R, Zeiser Robert, Blazar Bruce R, ;2015;Blood;125;3183-92; 25814531