B6.129S2-Ighmtm1Cgn/CgnOrl

Status

Available to order

EMMA IDEM:00001
International strain nameB6.129S2-Ighmtm1Cgn/CgnOrl
Alternative namemuMT°(muKO)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIghmtm1Cgn
Gene/Transgene symbolIghm

Information from provider

ProviderKlaus Rajewsky
Provider affiliationCBR Institute for Biomedical Research, Immune Disease Institute
Genetic informationMutant mice in the constant region of the immunoglobulin heavy chain 6 (heavy chain of IgM, Ighm) gene. Obtained by mutation of the gene by homologous recombination (insertion of the neo gene into the membrane domain-coding exon).
Phenotypic informationNormal development of B cells in heterozygous animals. Absent in homozygotes; development stops at pre-B stage.
Breeding history129S2/Sv ES cells; 10 generations of backcross to C57BL/6, then intercross.
References
  • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.;Kitamura D, Roes J, Kühn R, Rajewsky K, ;1991;Nature;350;423-6; 1901381

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6J, wild-type C57BL/6J
Breeding at archiving centreMales homozygous or heterozygous

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased susceptibility to autoimmune diabetes / MGI
  • arrested B cell differentiation / MGI
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal spleen morphology / MGI
  • abnormal cardiovascular system physiology / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • abnormal respiratory system physiology / MGI
  • decreased immunoglobulin level / MGI
  • decreased IgE level / MGI
  • abnormal cytokine secretion / MGI
  • abnormal compact bone morphology / MGI
  • decreased spleen weight / MGI
  • increased susceptibility to parasitic infection / MGI
  • decreased susceptibility to injury / MGI
  • immune system phenotype / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased dendritic cell number / MGI
  • decreased IgG1 level / MGI
  • decreased trabecular bone thickness / MGI
  • decreased compact bone volume / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • abnormal T cell proliferation / MGI
  • abnormal T cell number / MGI
  • absent B cells / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • insulitis / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal CD8 positive, alpha-beta intraepithelial T cell morphology / MGI
  • decreased IgA level / MGI
  • abnormal antigen presentation / MGI
  • abnormal spleen marginal sinus morphology / MGI
  • increased susceptibility to induced arthritis / MGI
  • increased osteoclast cell number / MGI
  • decreased T cell proliferation / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • absent follicular dendritic cells / MGI
  • absent mature B cells / MGI
  • abnormal spleen marginal zone macrophage morphology / MGI
  • abnormal metallophilic macrophage morphology / MGI
  • decreased IgM level / MGI
  • abnormal lymphatic vessel morphology / MGI
  • abnormal B cell differentiation / MGI
  • abnormal response to infection / MGI
  • respiratory system phenotype / MGI
  • absent immature B cells / MGI
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal cardiovascular system physiology / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • arrested B cell differentiation / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • abnormal antigen presentation / MGI
  • kidney inflammation / MGI
  • abnormal lymphatic vessel morphology / MGI
  • abnormal respiratory system physiology / MGI
  • abnormal B cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • small lymph nodes / MGI
  • abnormal spleen white pulp morphology / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen germinal center morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal spleen marginal sinus morphology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal complement pathway / MGI
  • impaired complement classical pathway / MGI
  • decreased IgE level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • abnormal immune serum protein physiology / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • increased susceptibility to induced arthritis / MGI
  • increased autoantibody level / MGI
  • abnormal compact bone morphology / MGI
  • insulitis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • abnormal class switch recombination / MGI
  • decreased spleen weight / MGI
  • increased B-1 B cell number / MGI
  • decreased B-1 B cell number / MGI
  • increased osteoclast cell number / MGI
  • increased B cell number / MGI
  • decreased B cell number / MGI
  • abnormal immature B cell morphology / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • decreased B cell proliferation / MGI
  • abnormal T cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • increased B cell proliferation / MGI
  • decreased susceptibility to injury / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal T cell number / MGI
  • absent B cells / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased plasma cell number / MGI
  • abnormal plasma cell differentiation / MGI
  • decreased dendritic cell number / MGI
  • decreased Peyer's patch number / MGI
  • small Peyer's patches / MGI
  • abnormal B-1a B cell morphology / MGI
  • abnormal mature B cell morphology / MGI
  • decreased follicular B cell number / MGI
  • increased marginal zone B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • abnormal follicular dendritic cell antigen presentation / MGI
  • absent follicular dendritic cells / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • absent mature B cells / MGI
  • absent immature B cells / MGI
  • decreased immature B cell number / MGI
  • abnormal B cell activation / MGI
  • abnormal spleen marginal zone macrophage morphology / MGI
  • abnormal metallophilic macrophage morphology / MGI
  • abnormal CD8 positive, alpha-beta intraepithelial T cell morphology / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased IgG2a level / MGI
  • increased IgG3 level / MGI
  • abnormal splenic cell ratio / MGI
  • decreased trabecular bone thickness / MGI
  • decreased compact bone volume / MGI

Literature references

  • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.;Kitamura D, Roes J, Kühn R, Rajewsky K, ;1991;Nature;350;423-6; 1901381
  • Invariant NKT cells sustain specific B cell responses and memory.;Galli Grazia, Pittoni Paola, Tonti Elena, Malzone Carmine, Uematsu Yasushi, Tortoli Marco, Maione Domenico, Volpini Gianfranco, Finco Oretta, Nuti Sandra, Tavarini Simona, Dellabona Paolo, Rappuoli Rino, Casorati Giulia, Abrignani Sergio, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;3984-9; 17360464

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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