STOCK Tg(Camk2a-Grin2c/itTA)10Rsp/Kctt

Status

Available to order

EMMA IDEM:09255
International strain nameSTOCK Tg(Camk2a-Grin2c/itTA)10Rsp/Kctt
Alternative nameTgCN10
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Camk2a-Grin2c/itTA)10Rsp
Gene/Transgene symbolTg(Camk2a-Grin2c/itTA)10Rsp

Information from provider

ProviderRolf Sprengel
Provider affiliationMolecular Neurobiology, Max Planck Institute for Medical Research
Genetic informationThe expression of the humanized version of the "improved" tetracycline transactivator (itTA) protein is controlled by the CamkII promoter and the neuron specific silencer of the Grin2c (glutamate receptor, ionotropic, epsilon 3) gene. The expression is restricted to granular cells of the hippocampus.
Phenotypic informationHomozygous:
not known

Heterozygous:
Very bad breeders when backcrossed to C57BL/6.
Breeding history60 het embryos (2-cells stage) generated on Oct 23, 2013
References
  • Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus.;Niewoehner B, Single F N, Hvalby Ø, Jensen V, Meyer zum Alten Borgloh S, Seeburg P H, Rawlins J N P, Sprengel R, Bannerman D M, ;2007;The European journal of neuroscience;25;837-46; 17313573
  • Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation.;Watanabe Yasuhito, Müller Michaela K, von Engelhardt Jakob, Sprengel Rolf, Seeburg Peter H, Monyer Hannah, ;2015;Frontiers in molecular neuroscience;8;87; 26793056
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Animals used for archivingheterozygous NMRI

Literature references

  • Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus.;Niewoehner B, Single F N, Hvalby Ø, Jensen V, Meyer zum Alten Borgloh S, Seeburg P H, Rawlins J N P, Sprengel R, Bannerman D M, ;2007;The European journal of neuroscience;25;837-46; 17313573
  • Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation.;Watanabe Yasuhito, Müller Michaela K, von Engelhardt Jakob, Sprengel Rolf, Seeburg Peter H, Monyer Hannah, ;2015;Frontiers in molecular neuroscience;8;87; 26793056

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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