MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6N.129-Gria3tm1Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09215 |
| Citation information | RRID:IMSR_EM:09215 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.129-Gria3tm1Rsp/Kctt |
| Alternative name | Gria3tm2Rsp (Lab name RC2) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gria3tm1Rsp |
| Gene/Transgene symbol | Gria3 |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | The Gria3fl floxed exon 11 allele allows deletion of the sequences encoding the glutamate receptor transmembrane domain ion channel pore in cells/tissues expressing Cre-recombinase. These mice are useful in applications related to the study of behavioral, social and cognitive abnormalities. |
| Phenotypic information | Homozygous:No PhenotypeHeterozygous:No Phenotype |
| Breeding history | Generated in 2000. Embryos frozen 2002 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- X-linked intellectual disability due to GRIA3 mutations / Orphanet_364028
Literature references
- Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach.;Lu Wei, Shi Yun, Jackson Alexander C, Bjorgan Kirsten, During Matthew J, Sprengel Rolf, Seeburg Peter H, Nicoll Roger A, ;2009;Neuron;62;254-68; 19409270
- Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.;Kougioumtzidou Eleni, Shimizu Takahiro, Hamilton Nicola B, Tohyama Koujiro, Sprengel Rolf, Monyer Hannah, Attwell David, Richardson William D, ;2017;eLife;6;108824; 28608780
- Synaptic plasticity through activation of GluA3-containing AMPA-receptors.;Renner Maria C, Albers Eva Hh, Gutierrez-Castellanos Nicolas, Reinders Niels R, van Huijstee Aile N, Xiong Hui, Lodder Tessa R, Kessels Helmut W, ;2017;eLife;6;5083; 28762944
- Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain.;Watson Jake F, Ho Hinze, Greger Ingo H, ;2017;eLife;6;; 28290985
- An inhalation anaesthesia approach for neonatal mice allowing streamlined stereotactic injection in the brain.;Ho Hinze, Fowle Adam, Coetzee Marisa, Greger Ingo H, Watson Jake F, ;2020;Journal of neuroscience methods;342;; 32569783
- AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.;Watson Jake F, Pinggera Alexandra, Ho Hinze, Greger Ingo H, ;2021;Nature communications;12;; 34426577